1d9r

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[[Image:1d9r.gif|left|200px]]
 
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==CRYSTAL STRUCTURE OF DNA SHEARED TANDEM G-A BASE PAIRS==
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The line below this paragraph, containing "STRUCTURE_1d9r", creates the "Structure Box" on the page.
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<StructureSection load='1d9r' size='340' side='right'caption='[[1d9r]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1d9r]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D9R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1D9R FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BRU:5-BROMO-2-DEOXYURIDINE-5-MONOPHOSPHATE'>BRU</scene>, <scene name='pdbligand=NCO:COBALT+HEXAMMINE(III)'>NCO</scene></td></tr>
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{{STRUCTURE_1d9r| PDB=1d9r | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1d9r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1d9r OCA], [https://pdbe.org/1d9r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1d9r RCSB], [https://www.ebi.ac.uk/pdbsum/1d9r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1d9r ProSAT]</span></td></tr>
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</table>
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'''CRYSTAL STRUCTURE OF DNA SHEARED TANDEM G-A BASE PAIRS'''
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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==Overview==
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[[Category: Gao Y-G]]
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G x A mismatched base pairs are frequently found in nucleic acids. Human centromere DNA sequences contain unusual repeating motifs, e.g. , (GAATG)n x (CATTC)n found in the human chromosome. The purine-rich strand of this repeating pentamer sequence forms duplex and hairpin structures with unusual stability. The high stability of these structures is contributed by the "sheared" G x A base pairs which present a novel recognition surface for ligands and proteins. We have solved the crystal structure, by the multiple-wavelength anomalous diffraction (MAD) method of d(CCGAATGAGG) in which the centromere core sequence motif GAATG is embedded. Three crystal forms were refined to near-atomic resolution. The structures reveal the detailed conformation of tandem G x A base pairs whose unique hydrogen-bonding surface has interesting interactions with bases, hydrated magnesium ions, cobalt(III)hexaammine, spermine, and water molecules. The results are relevant in understanding the structure associated with human centromere sequence in particular and G x A base pairs in nucleic acids (including RNA, like ribozyme) in general.
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[[Category: Joachimiak A]]
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[[Category: Robinson H]]
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==About this Structure==
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[[Category: Sanishvili R]]
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D9R OCA].
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[[Category: Wang AH-J]]
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==Reference==
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Structure and recognition of sheared tandem G x A base pairs associated with human centromere DNA sequence at atomic resolution., Gao YG, Robinson H, Sanishvili R, Joachimiak A, Wang AH, Biochemistry. 1999 Dec 14;38(50):16452-60. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10600106 10600106]
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[[Category: Gao, Y G.]]
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[[Category: Joachimiak, A.]]
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[[Category: Robinson, H.]]
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[[Category: Sanishvili, R.]]
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[[Category: Wang, A H.J.]]
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[[Category: Deoxyribonucleic acid]]
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[[Category: Ga mismatch]]
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[[Category: Tandem ga base pair]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 13:36:29 2008''
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CRYSTAL STRUCTURE OF DNA SHEARED TANDEM G-A BASE PAIRS

PDB ID 1d9r

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