1dab

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[[Image:1dab.jpg|left|200px]]
 
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==The Structure of Bordetella Pertussis Virulence Factor P.69 Pertactin==
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The line below this paragraph, containing "STRUCTURE_1dab", creates the "Structure Box" on the page.
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<StructureSection load='1dab' size='340' side='right'caption='[[1dab]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1dab]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bordetella_pertussis Bordetella pertussis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DAB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DAB FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dab FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dab OCA], [https://pdbe.org/1dab PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dab RCSB], [https://www.ebi.ac.uk/pdbsum/1dab PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dab ProSAT]</span></td></tr>
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{{STRUCTURE_1dab| PDB=1dab | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PERT_BORPE PERT_BORPE] Agglutinogen that binds to eukaryotic cells; a process mediated by the R-G-D sequence. Pertactin may have a role in bacterial adhesion, and thus play a role in virulence. May contribute to the disease state of whooping cough.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/da/1dab_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1dab ConSurf].
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<div style="clear:both"></div>
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'''The Structure of Bordetella Pertussis Virulence Factor P.69 Pertactin'''
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==See Also==
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*[[Pertussis toxin|Pertussis toxin]]
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__TOC__
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==Overview==
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</StructureSection>
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A new generation of whooping-cough vaccines contain P.69 pertactin, a surface-exposed domain of an outer membrane protein expressed by the virulent bacterium Bordetella pertussis. This protein is a virulence factor that mediates adhesion to target mammalian cells, a reaction that is in part mediated by an RGD sequence. The X-ray crystal structure of P.69 pertactin has been determined to 2.5 A. The protein fold consists of a 16-stranded parallel beta-helix with a V-shaped cross-section, and is the largest beta-helix known to date. Several between-strand weakly conserved amino-acid repeats form internal and external ladders. The structure appears as a helix from which several loops protrude, which contain sequence motifs associated with the biological activity of the protein. One particular (GGXXP)5 sequence is located directly after the RGD motif, and may mediate interaction with epithelial cells. The carboxy-terminal region of P.69 pertactin incorporates a (PQP)5 motif loop containing the major immunoprotective epitope.
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==About this Structure==
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1DAB is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bordetella_pertussis Bordetella pertussis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DAB OCA].
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==Reference==
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Structure of Bordetella pertussis virulence factor P.69 pertactin., Emsley P, Charles IG, Fairweather NF, Isaacs NW, Nature. 1996 May 2;381(6577):90-2. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8609998 8609998]
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[[Category: Bordetella pertussis]]
[[Category: Bordetella pertussis]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Charles, I G.]]
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[[Category: Charles IG]]
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[[Category: Emsley, P.]]
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[[Category: Emsley P]]
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[[Category: Fairweather, N F.]]
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[[Category: Fairweather NF]]
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[[Category: Isaacs, N W.]]
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[[Category: Isaacs NW]]
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[[Category: Pertussis beta helix]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 13:37:27 2008''
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Current revision

The Structure of Bordetella Pertussis Virulence Factor P.69 Pertactin

PDB ID 1dab

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