7d5l

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==Discovery of BMS-986144, a Third Generation, Pan Genotype NS3/4A Protease Inhibitor for the Treatment of Hepatitis C Virus Infection==
==Discovery of BMS-986144, a Third Generation, Pan Genotype NS3/4A Protease Inhibitor for the Treatment of Hepatitis C Virus Infection==
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<StructureSection load='7d5l' size='340' side='right'caption='[[7d5l]]' scene=''>
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<StructureSection load='7d5l' size='340' side='right'caption='[[7d5l]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7D5L OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=7D5L FirstGlance]. <br>
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<table><tr><td colspan='2'>[[7d5l]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Hepacivirus_C Hepacivirus C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7D5L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7D5L FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=7d5l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7d5l OCA], [http://pdbe.org/7d5l PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=7d5l RCSB], [http://www.ebi.ac.uk/pdbsum/7d5l PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=7d5l ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GXO:[1,1,1-tris(fluoranyl)-2-methyl-propan-2-yl]+~{N}-[(1~{S},4~{R},6~{S},7~{Z},11~{R},13~{R},14~{S},18~{R})-13-ethyl-18-(7-fluoranyl-6-methoxy-isoquinolin-1-yl)oxy-11-methyl-4-[(1-methylcyclopropyl)sulfonylcarbamoyl]-2,15-bis(oxidanylidene)-3,16-diazatricyclo[14.3.0.0^{4,6}]nonadec-7-en-14-yl]carbamate'>GXO</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7d5l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7d5l OCA], [https://pdbe.org/7d5l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7d5l RCSB], [https://www.ebi.ac.uk/pdbsum/7d5l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7d5l ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/A0A0B4WYC6_9HEPC A0A0B4WYC6_9HEPC]
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==See Also==
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*[[Virus protease 3D structures|Virus protease 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Hepacivirus C]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Anumula R]]
[[Category: Anumula R]]
[[Category: Ghosh K]]
[[Category: Ghosh K]]
[[Category: Kumar A]]
[[Category: Kumar A]]

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Discovery of BMS-986144, a Third Generation, Pan Genotype NS3/4A Protease Inhibitor for the Treatment of Hepatitis C Virus Infection

PDB ID 7d5l

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