7dl2

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====
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==Cryo-EM structure of human TSC complex==
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<StructureSection load='7dl2' size='340' side='right'caption='[[7dl2]]' scene=''>
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<StructureSection load='7dl2' size='340' side='right'caption='[[7dl2]], [[Resolution|resolution]] 4.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
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<table><tr><td colspan='2'>[[7dl2]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7DL2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7DL2 FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=7dl2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7dl2 OCA], [http://pdbe.org/7dl2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=7dl2 RCSB], [http://www.ebi.ac.uk/pdbsum/7dl2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=7dl2 ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.4&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7dl2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7dl2 OCA], [https://pdbe.org/7dl2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7dl2 RCSB], [https://www.ebi.ac.uk/pdbsum/7dl2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7dl2 ProSAT]</span></td></tr>
</table>
</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/TSC1_HUMAN TSC1_HUMAN] Lymphangioleiomyomatosis;Tuberous sclerosis;Isolated focal cortical dysplasia type IIb. The disease is caused by mutations affecting the gene represented in this entry. The disease may be caused by mutations affecting the gene represented in this entry.
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== Function ==
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[https://www.uniprot.org/uniprot/TSC1_HUMAN TSC1_HUMAN] In complex with TSC2, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Seems not to be required for TSC2 GAP activity towards RHEB. Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling.<ref>PMID:12271141</ref> <ref>PMID:15340059</ref>
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Z-disk]]
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[[Category: Chen X]]
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[[Category: Cheng J]]
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[[Category: Gao N]]
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[[Category: Guan K]]
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[[Category: Li J]]
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[[Category: Li N]]
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[[Category: Xu Y]]
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[[Category: Yang H]]
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[[Category: Ye D]]
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[[Category: Yu Z]]
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[[Category: Yuan H]]

Current revision

Cryo-EM structure of human TSC complex

PDB ID 7dl2

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OCA

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