6yfs

<table><tr><td colspan='2'>[[6yfs]] is a 90 chain structure with sequence from [http://en.wikipedia.org/wiki/Leviviridae_sp. Leviviridae sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6YFS OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6YFS FirstGlance]. <br>

</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[6yf7|6yf7]], [[6yf9|6yf9]], [[6yfa|6yfa]], [[6yfb|6yfb]], [[6yfc|6yfc]], [[6yfd|6yfd]], [[6yfe|6yfe]], [[6yff|6yff]], [[6yfg|6yfg]], [[6yfh|6yfh]], [[6yfi|6yfi]], [[6yfj|6yfj]], [[6yfk|6yfk]], [[6yfl|6yfl]], [[6yfm|6yfm]], [[6yfn|6yfn]], [[6yfo|6yfo]], [[6yfp|6yfp]], [[6yfq|6yfq]], [[6yfr|6yfr]], [[6yft|6yft]], [[6yfu|6yfu]]</div></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6yfs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6yfs OCA], [http://pdbe.org/6yfs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6yfs RCSB], [http://www.ebi.ac.uk/pdbsum/6yfs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6yfs ProSAT]</span></td></tr>

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== Publication Abstract from PubMed ==

The single-stranded RNA (ssRNA) bacteriophages are among the simplest known viruses with small genomes and exceptionally high mutation rates. The number of ssRNA phage isolates has remained very low, but recent metagenomic studies have uncovered an immense variety of distinct uncultured ssRNA phages. The coat proteins (CPs) in these genomes are particularly diverse, with notable variation in length and often no recognizable similarity to previously known viruses. We recombinantly expressed metagenome-derived ssRNA phage CPs to produce virus-like particles and determined the three-dimensional structure of 22 previously uncharacterized ssRNA phage capsids covering nine distinct CP types. The structures revealed substantial deviations from the previously known ssRNA phage CP fold, uncovered an unusual prolate particle shape, and revealed a previously unseen dsRNA binding mode. These data expand our knowledge of the evolution of viral structural proteins and are of relevance for applications such as ssRNA phage-based vaccine design.

 

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== References ==

[[Category: Kalnins, G]]

[[Category: Lieknina, I]]

[[Category: Rumnieks, J]]

[[Category: Sisovs, M]]

[[Category: Tars, K]]

[[Category: Virus-like particle]]