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1r2q

From Proteopedia

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Current revision (05:59, 23 August 2023) (edit) (undo)
 
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<StructureSection load='1r2q' size='340' side='right'caption='[[1r2q]], [[Resolution|resolution]] 1.05&Aring;' scene=''>
<StructureSection load='1r2q' size='340' side='right'caption='[[1r2q]], [[Resolution|resolution]] 1.05&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1r2q]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R2Q OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1R2Q FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1r2q]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R2Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1R2Q FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.05&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1n6h|1n6h]], [[1n6i|1n6i]], [[1n6k|1n6k]], [[1n6l|1n6l]], [[1n6n|1n6n]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RAB5A OR RAB5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1r2q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r2q OCA], [https://pdbe.org/1r2q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1r2q RCSB], [https://www.ebi.ac.uk/pdbsum/1r2q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1r2q ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1r2q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r2q OCA], [http://pdbe.org/1r2q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1r2q RCSB], [http://www.ebi.ac.uk/pdbsum/1r2q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1r2q ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/RAB5A_HUMAN RAB5A_HUMAN]] Required for the fusion of plasma membranes and early endosomes. Contributes to the regulation of filopodia extension.<ref>PMID:14978216</ref>
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[https://www.uniprot.org/uniprot/RAB5A_HUMAN RAB5A_HUMAN] Required for the fusion of plasma membranes and early endosomes. Contributes to the regulation of filopodia extension.<ref>PMID:14978216</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Li, G]]
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[[Category: Li G]]
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[[Category: Terzyan, S]]
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[[Category: Terzyan S]]
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[[Category: Zhang, X C]]
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[[Category: Zhang XC]]
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[[Category: Zhu, G]]
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[[Category: Zhu G]]
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[[Category: Atomic resolution]]
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[[Category: Gnp]]
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[[Category: Gtpase]]
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[[Category: Protein transport]]
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[[Category: Rab]]
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Current revision

Crystal Structure of Human Rab5a GTPase Domain at 1.05 A resolution

PDB ID 1r2q

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