TRNA methyltransferase 3D structures

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Current revision (07:53, 20 August 2024) (edit) (undo)
 
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Line 8: Line 8:
**[[6w14]] – MsTrm – ''Mycobacterium smegmatis''<br />
**[[6w14]] – MsTrm – ''Mycobacterium smegmatis''<br />
**[[6w15]] – MsTrm + SAH <br />
**[[6w15]] – MsTrm + SAH <br />
-
**[[7kff]] – Trm – ''Corynebacterium diphtheriae''<br />
+
**[[7kff]] – CdTrm – ''Corynebacterium diphtheriae''<br />
-
**[[3knu]], [[6uev]] – ApTrm – ''Anaplasma phagocytophilum''<br />
+
**[[3knu]], [[8sh4]] – ApTrm – ''Anaplasma phagocytophilum''<br />
*'''tRNA guanine 9 N1 methyltransferase'''
*'''tRNA guanine 9 N1 methyltransferase'''
Line 17: Line 17:
**[[4jwj]] – yTrm + SAH – yeast<br />
**[[4jwj]] – yTrm + SAH – yeast<br />
-
*'''tRNA guanine 37 N1 methyltransferase'''
+
*'''tRNA guanine 37 N1 methyltransferase or TrmD'''
**[[1oy5]] – AaTrm – ''Aquifex aeolicus'' <br />
**[[1oy5]] – AaTrm – ''Aquifex aeolicus'' <br />
**[[3ief]] – Trm – ''Bartonella henselae'' <br />
**[[3ief]] – Trm – ''Bartonella henselae'' <br />
**[[1uaj]] – HiTrm – ''Haemophilus influenzae''<br />
**[[1uaj]] – HiTrm – ''Haemophilus influenzae''<br />
-
**[[3ky7]] – Trm – ''Staphylococcus aureus''<br />
+
**[[3ky7]] – SaTrm – ''Staphylococcus aureus''<br />
-
**[[3quv]], [[6nvr]] – MaTrmD – ''Mycobacterium abscessus''<br />
+
**[[3quv]], [[6nvr]], [[7rey]] – MaTrmD – ''Mycobacterium abscessus''<br />
**[[5hjj]], [[5yac]] – PabTrm – ''Pyrococcus abyssi''<br />
**[[5hjj]], [[5yac]] – PabTrm – ''Pyrococcus abyssi''<br />
**[[6jki]] – PaTrmD – ''Pseudomonas aeruginosa''<br />
**[[6jki]] – PaTrmD – ''Pseudomonas aeruginosa''<br />
**[[5zhi]] – MtTrm – ''Mycobacterium tuberculosis''<br />
**[[5zhi]] – MtTrm – ''Mycobacterium tuberculosis''<br />
 +
**[[7myq]] – AbTrm – ''Acinetobacter baumannii'' <br />
*Complexes of tRNA guanine 37 N1 methyltransferase
*Complexes of tRNA guanine 37 N1 methyltransferase
Line 48: Line 49:
**[[6qo2]], [[6qo3]], [[6qo4]], [[6qo6]], [[6qoa]], [[6qoc]], [[6qod]], [[6qoe]], [[6qof]], [[6qog]], [[6qoh]], [[6qoi]], [[6qoj]], [[6qok]], [[6qol]], [[6qom]], [[6qon]], [[6qoo]], [[6qop]], [[6qoq]], [[6qor]], [[6qos]], [[6qot]], [[6qou]], [[6qov]], [[6qow]], [[6qox]], [[6qqq]], [[6qqr]], [[6qqt]], [[6qqu]], [[6qqv]], [[6qqw]], [[6qqz]], [[6qr0]], [[6qr1]], [[6qr2]], [[6qr3]], [[6qr4]], [[6qr7]], [[6qr9]], [[6qra]], [[6qrc]], [[6qrd]], [[6qre]], [[6qrf]], [[6qrg]] – MaTrmD + inhibitor<br />
**[[6qo2]], [[6qo3]], [[6qo4]], [[6qo6]], [[6qoa]], [[6qoc]], [[6qod]], [[6qoe]], [[6qof]], [[6qog]], [[6qoh]], [[6qoi]], [[6qoj]], [[6qok]], [[6qol]], [[6qom]], [[6qon]], [[6qoo]], [[6qop]], [[6qoq]], [[6qor]], [[6qos]], [[6qot]], [[6qou]], [[6qov]], [[6qow]], [[6qox]], [[6qqq]], [[6qqr]], [[6qqt]], [[6qqu]], [[6qqv]], [[6qqw]], [[6qqz]], [[6qr0]], [[6qr1]], [[6qr2]], [[6qr3]], [[6qr4]], [[6qr7]], [[6qr9]], [[6qra]], [[6qrc]], [[6qrd]], [[6qre]], [[6qrf]], [[6qrg]] – MaTrmD + inhibitor<br />
**[[6nw6]] – MaTrmD + SAM <br />
**[[6nw6]] – MaTrmD + SAM <br />
-
**[[6nw7]] – MaTrmD + SAH <br />
+
**[[6nw7]], [[7rez]], [[7rf0]] – MaTrmD + SAH <br />
**[[6joe]], [[6jof]], [[5zhm]], [[5zhn]], [[6afk]] – PaTrmD + inhibitor<br />
**[[6joe]], [[6jof]], [[5zhm]], [[5zhn]], [[6afk]] – PaTrmD + inhibitor<br />
**[[6wyq]] – PaTrmD + SAM <br />
**[[6wyq]] – PaTrmD + SAM <br />
Line 57: Line 58:
**[[5hji]] – PabTrm5a + adenosine<br />
**[[5hji]] – PabTrm5a + adenosine<br />
**[[5wt3]] – PabTrm5a + tRNA + methylthioadenosine<br />
**[[5wt3]] – PabTrm5a + tRNA + methylthioadenosine<br />
 +
**[[7mys]] – AbTrmD + SAH <br />
 +
**[[7kff]] – CdTrmD + SAH <br />
*'''tRNA guanine 46 N7 methyltransferase'''
*'''tRNA guanine 46 N7 methyltransferase'''
Line 62: Line 65:
**[[2vdu]], [[2vdv]] – yTrm8 <br />
**[[2vdu]], [[2vdv]] – yTrm8 <br />
**[[1yzh]] – Trm – ''Streptococcus pneumoniae'' <br />
**[[1yzh]] – Trm – ''Streptococcus pneumoniae'' <br />
-
**[[2fca]] – BsTrmB – ''Bacillus subtilis'' <br />
+
**[[2fca]], [[7nzj]] – BsTrmB – ''Bacillus subtilis'' <br />
**[[3dxx]] – EcTrmB <br />
**[[3dxx]] – EcTrmB <br />
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**[[3ckk]] – hTrm + SAM - human<br />
**[[3ckk]] – hTrm + SAM - human<br />
 +
**[[7pl1]] – hTrm + sinefungin<br />
 +
**[[7ogj]] – hTrm + SAH <br />
**[[3dxy]] – EcTrmB + SAM <br />
**[[3dxy]] – EcTrmB + SAM <br />
**[[3dxz]] – EcTrmB + SAH <br />
**[[3dxz]] – EcTrmB + SAH <br />
 +
**[[7nyb]] – BsTrmD + SAM <br />
 +
**[[7nzi]] – BsTrmD + SAH<br />
 +
 +
*Trm to O2 of guanosine 18
 +
 +
**[[7edc]] – EcTrmH (mutant) + SAM<br />
*Trm to O2 of cytidine 32
*Trm to O2 of cytidine 32
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**[[4xbo]] – EcTrmJ + SAH<br />
**[[4xbo]] – EcTrmJ + SAH<br />
**[[4cne]] – EcTrmJ (mutant) + SAH<br />
**[[4cne]] – EcTrmJ (mutant) + SAH<br />
 +
 +
*METTL6 to cytidine 32
 +
 +
**[[7f1e]] – hMETTL6 + SAM<br />
 +
**[[7ezg]] – hMETTL6 + SAH<br />
*'''tRNA cytidine 34 O2 methyltransferase YibK'''
*'''tRNA cytidine 34 O2 methyltransferase YibK'''
Line 82: Line 98:
**[[3e5y]] – BpTrmH – ''Burkholderia pseudomalllei'' <br />
**[[3e5y]] – BpTrmH – ''Burkholderia pseudomalllei'' <br />
**[[4jak]], [[4kdz]] – EcTrmL <br />
**[[4jak]], [[4kdz]] – EcTrmL <br />
 +
**[[7e3s]] – TrmL – ''Shewanella oneidensis<''br />
 +
**[[7e3r]] – VvTrmL – ''Vibrio vulnificus''<br />
 +
**[[1j85]], [[6ahw]], [[7d51]] – HiYibK<br />
**[[6qkv]], [[6qh8]] – PaYibK <br />
**[[6qkv]], [[6qh8]] – PaYibK <br />
**[[6ahw]] – HiTrm <br />
**[[6ahw]] – HiTrm <br />
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**[[3n4k]], [[3n4j]] – Trm + SAH – ''Yersinia pestis'' <br />
**[[3n4k]], [[3n4j]] – Trm + SAH – ''Yersinia pestis'' <br />
**[[1mxi]], [[1im8]] – HiTrm + SAH <br />
**[[1mxi]], [[1im8]] – HiTrm + SAH <br />
-
**[[1j85]], [[6ahw]] – HiYibK<br />
 
**[[4jal]] – EcYibK + SAH<br />
**[[4jal]] – EcYibK + SAH<br />
 +
**[[7e3q]] – VvTrm + SAH <br />
*Trm to C5 of cytidine 38
*Trm to C5 of cytidine 38
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**[[6q56]] – BsTrm (mutant)<br />
**[[6q56]] – BsTrm (mutant)<br />
-
**[[6qe6]] – TrmK + SAH - ''Mycoplasma capricolum''6<br />
+
**[[6qe6]] – TrmK + SAH - ''Mycoplasma capricolum''<br />
 +
**[[7o4m]] – SaTrm <br />
 +
**[[7o4o]] – SaTrm + SAH<br />
 +
**[[7o4n]] – SaTrm + SAM<br />
*'''tRNA adenine 58 N1 methyltransferase'''
*'''tRNA adenine 58 N1 methyltransferase'''
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**[[4qnu]], [[4qnv]] – EcTrm + SAM derivative<br />
**[[4qnu]], [[4qnv]] – EcTrm + SAM derivative<br />
-
*'''tRNA uracil 54 methyltransferase'''
+
*Trm9-Trm112 to uracil 34
-
**[[3bt7]] – yTrmA + RNA<br />
+
**[[5cm2]] – Trm – ''Yarrowia lipolytica''<br />
-
*Trm9-TRM112
+
*'''tRNA uracil 54 methyltransferase'''
-
**[[5cm2]] – Trm – ''Yarrowia lipolytica''<br />
+
**[[3bt7]] – yTrmA + RNA<br />
-
*Trm dual specificity
+
*Trm dual specificity Rlmn
**[[4pl1]], [[4pl2]] – EcTrm Rlmn (mutant) + SAM<br />
**[[4pl1]], [[4pl2]] – EcTrm Rlmn (mutant) + SAM<br />
-
**[[5hr7]], [[5hr6]] – EcTrm RlmN (mutant) + tRNA-Glu<br />
+
**[[5hr6]], [[5hr7]] – EcTrm RlmN (mutant) + tRNA-Glu<br />
*Trm10 dual specificity to N1 of adenine 9/guanine 9
*Trm10 dual specificity to N1 of adenine 9/guanine 9
 +
**[[7onu]] – hTrm10 in RNase P complex – Cryo EM<br />
**[[6ems]], [[6emt]] – TkTrm10 (mutant)<br />
**[[6ems]], [[6emt]] – TkTrm10 (mutant)<br />
**[[6emv]] – TkTrm10 (mutant) + SAH<br />
**[[6emv]] – TkTrm10 (mutant) + SAH<br />

Current revision

3D structures of tRNA methyltransferase

Updated on 20-August-2024 - For a general description of the protein see TRNA methyltransferase

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman

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