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Gyrase 3D Structures
From Proteopedia
(Difference between revisions)
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{{#tree:id=OrganizedByTopic|openlevels=0| | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
| - | *Gyrase Subunit A | + | *Gyrase Subunit A; Domains – N-terminal 1-523; C-terminal 535-841 |
**[[3l6v]] – GyrA C-terminal – ''Xanthomonas campestris'' <br /> | **[[3l6v]] – GyrA C-terminal – ''Xanthomonas campestris'' <br /> | ||
| - | **[[2y3p]], [[4ckl]] – EcGyrA N-terminal+ | + | **[[1ajb]], [[2y3p]], [[4ckl]] – EcGyrA N-terminal + drug – ''Escherichia coli''<br /> |
| - | + | ||
**[[4ckk]] - EcGyrA N-terminal<br /> | **[[4ckk]] - EcGyrA N-terminal<br /> | ||
**[[1zi0]], [[1ab4]] - EcGyrA C-terminal<br /> | **[[1zi0]], [[1ab4]] - EcGyrA C-terminal<br /> | ||
**[[1x75]] – EcGyrA14+CcdB<br /> | **[[1x75]] – EcGyrA14+CcdB<br /> | ||
**[[4elz]] - GyrA fragment+CcdB – ''Vibrio fischeri''<br /> | **[[4elz]] - GyrA fragment+CcdB – ''Vibrio fischeri''<br /> | ||
| - | **[[3ilw]], [[3ifz]] - MtGyrA | + | **[[3ilw]], [[3ifz]] - MtGyrA N-terminal – ''Mycobacterium tuberculosis''<br /> |
**[[3uc1]], [[4g3n]] - MtGyrA C-terminal<br /> | **[[3uc1]], [[4g3n]] - MtGyrA C-terminal<br /> | ||
**[[1suu]] - GyrA C-terminal – ''Borrelia burgdorferi''<br /> | **[[1suu]] - GyrA C-terminal – ''Borrelia burgdorferi''<br /> | ||
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**[[3lpx]] – GyrA N-terminal – ''Colwellia psychrerithraea''<br /> | **[[3lpx]] – GyrA N-terminal – ''Colwellia psychrerithraea''<br /> | ||
**[[4ely]] – GyrA residues 363-497 + CcdB – ''Shigella flexneri''<br /> | **[[4ely]] – GyrA residues 363-497 + CcdB – ''Shigella flexneri''<br /> | ||
| - | **[[4ddq]] – GyrA – ''Bacillus subtilis''<br /> | + | **[[4ddq]] – GyrA N-terminal – ''Bacillus subtilis''<br /> |
**[[6n1r]], [[6n1q]] – SpGyrA N-terminal – ''Streptococcus pneumoniae'' – Cryo EM<br /> | **[[6n1r]], [[6n1q]] – SpGyrA N-terminal – ''Streptococcus pneumoniae'' – Cryo EM<br /> | ||
**[[6n1p]] – SpGyrA N-terminal + DNA – Cryo EM<br /> | **[[6n1p]] – SpGyrA N-terminal + DNA – Cryo EM<br /> | ||
**[[5ztj]] - SeGyrA C-terminal – ''Salmonella enterica''<br /> | **[[5ztj]] - SeGyrA C-terminal – ''Salmonella enterica''<br /> | ||
| - | *Gyrase Subunit B | + | *Gyrase Subunit B; Domains – ATPase or N-terminal 1-220; C-terminal 448-675 |
| - | **[[3g75]], [[3g7b]], [[3g7e]], [[3ttz]], [[3u2d]], [[3u2k]], [[4p8o]], [[5cph]], [[5ctu]], [[5ctw]], [[5ctx]], [[5cty]] – GyrB N-terminal residues 2-234 + inhibitor – ''Staphylococcus aureus''<br /> | + | **[[3g75]], [[3g7b]], [[3g7e]], [[3ttz]], [[3u2d]], [[3u2k]], [[4p8o]], [[5cph]], [[5ctu]], [[5ctw]], [[5ctx]], [[5cty]], [[6tck]], [[6ttg]] – GyrB N-terminal residues 2-234 + inhibitor – ''Staphylococcus aureus''<br /> |
**[[5d6p]], [[5d6q]], [[5d7c]], [[5d7d]], [[5d7r]] - SaGyrB N-terminal + ligand<br /> | **[[5d6p]], [[5d6q]], [[5d7c]], [[5d7d]], [[5d7r]] - SaGyrB N-terminal + ligand<br /> | ||
| - | **[[5npk]], [[5npp]] - SaGyrB residues 410- | + | **[[5npk]], [[5npp]] - SaGyrB residues 410-543 + DNA<br /> |
**[[5mmn]], [[5mmo]], [[5mmp]] - EcGyrB N-terminal + antibacterial<br /> | **[[5mmn]], [[5mmo]], [[5mmp]] - EcGyrB N-terminal + antibacterial<br /> | ||
**[[4urm]], [[4uro]] - SaGyrB N-terminal + antibiotic<br /> | **[[4urm]], [[4uro]] - SaGyrB N-terminal + antibiotic<br /> | ||
**[[5zxm]] - SeGyrB N-terminal (mutant) <br /> | **[[5zxm]] - SeGyrB N-terminal (mutant) <br /> | ||
| + | **[[6j90]] - SeGyrB N-terminal + ATP<br /> | ||
**[[3cwv]] – GyrB truncated – ''Myxococcus xanthus''<br /> | **[[3cwv]] – GyrB truncated – ''Myxococcus xanthus''<br /> | ||
**[[4wub]], [[4wuc]], [[4wud]], [[4xtj]] - EcGyrB N-terminal<br /> | **[[4wub]], [[4wuc]], [[4wud]], [[4xtj]] - EcGyrB N-terminal<br /> | ||
**[[1kzn]], [[1ei1]], [[1aj6]] - EcGyrB N-terminal+ antibiotic<br /> | **[[1kzn]], [[1ei1]], [[1aj6]] - EcGyrB N-terminal+ antibiotic<br /> | ||
| - | **[[4duh]], [[4zvi]], [[5l3j]], [[6f8j]], [[4hyp]], [[6f86]], [[5z9q]], [[5z9p]], [[5z9b]], [[5z9e]], [[5z9f]], [[5z9l]], [[5z9m]], [[5z9n]], [[5z4o]], [[5z4h]] - EcGyrB N-terminal+ inhibitor<br /> | + | **[[4duh]], [[4zvi]], [[5l3j]], [[6f8j]], [[4hyp]], [[6f86]], [[5z9q]], [[5z9p]], [[5z9b]], [[5z9e]], [[5z9f]], [[5z9l]], [[5z9m]], [[5z9n]], [[5z4o]], [[5z4h]], [[6yd9]], [[7c7n]], [[7c7o]], [[7dor]], [[7dpr]], [[7dps]], [[7dqf]], [[7dqh]], [[7dqj]], [[7dqm]], [[7dqs]], [[7dqu]], [[7p2m]], [[7p2n]], [[7p2w]], [[7p2x]] - EcGyrB N-terminal+ inhibitor<br /> |
**[[4prv]], [[4prx]], [[4pu9]] - EcGyrB N-terminal+ ADP<br /> | **[[4prv]], [[4prx]], [[4pu9]] - EcGyrB N-terminal+ ADP<br /> | ||
**[[5mmn]], [[5mmo]], [[5mmp]] - EcGyrB N-terminal + antibacterial<br /> | **[[5mmn]], [[5mmo]], [[5mmp]] - EcGyrB N-terminal + antibacterial<br /> | ||
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**[[1kij]] – TtGyrB N-terminal+ antibiotic – ''Thermus thermophilus''<br /> | **[[1kij]] – TtGyrB N-terminal+ antibiotic – ''Thermus thermophilus''<br /> | ||
**[[6enh]], [[6eng]] - TtGyrB ATPase domain + coumarine derivative<br /> | **[[6enh]], [[6eng]] - TtGyrB ATPase domain + coumarine derivative<br /> | ||
| - | **[[4b6c]] - | + | **[[4b6c]] - MsGyrB N-terminal – ''Mycobacterium smegmatis''<br /> |
| - | **[[4gee]], [[4gfn]], [[4ggl]], [[4hxw]], [[4k4o]], [[4kfg]], [[4ksg]], [[4ksh]], [[4ktn]] – GyrB + inhibitor – ''Enterococcus faecalis''<br /> | + | **[[6zt5]] - MsGyrB + MfpA<br /> |
| + | **[[6zt3]] - MsGyrB + ANP<br /> | ||
| + | **[[4gee]], [[4gfn]], [[4ggl]], [[4hxw]], [[4k4o]], [[4kfg]], [[4ksg]], [[4ksh]], [[4ktn]] – GyrB N-terminal + inhibitor – ''Enterococcus faecalis''<br /> | ||
**[[2zjt]], [[3ig0]], [[3m4i]] - MtGyrB C-terminal<br /> | **[[2zjt]], [[3ig0]], [[3m4i]] - MtGyrB C-terminal<br /> | ||
**[[3zkb]], [[3zkd]] - MtGyrB N-terminal + AMPPNP<br /> | **[[3zkb]], [[3zkd]] - MtGyrB N-terminal + AMPPNP<br /> | ||
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**[[4bae]] - MtGyrB N-terminal (mutant) + inhibitor<br /> | **[[4bae]] - MtGyrB N-terminal (mutant) + inhibitor<br /> | ||
**[[6j90]] - GyrB N-terminal + ATP – ''Salmonella typhi''<br /> | **[[6j90]] - GyrB N-terminal + ATP – ''Salmonella typhi''<br /> | ||
| + | **[[6m1j]], [[6m1s]], [[7ptf]], [[7ptg]], [[8bn6]] - GyrB ATPase domain + inhibitor – ''Pseudomonas aeruginosa''<br /> | ||
| + | **[[6y8l]], [[6y8n]], [[6y8o]] - GyrB ATPase domain + drug – ''Mycobacterium thermoresistibile''<br /> | ||
| + | **[[7pqm]] - AbGyrB ATPase domain + inhibitor – Acinetobacter baumannii<br /> | ||
| + | **[[7pqi]] - AbGyrB ATPase domain + antibiotic<br /> | ||
*Gyrase Subunit A+Subunit B | *Gyrase Subunit A+Subunit B | ||
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**[[2xct]] - SaGyrB C-terminal/SaGyrA N-terminal (mutant) +DNA+ antibiotic<br /> | **[[2xct]] - SaGyrB C-terminal/SaGyrA N-terminal (mutant) +DNA+ antibiotic<br /> | ||
**[[4tma]] - SaGyrB C-terminal- + SaGyrA N-terminal + Gyr inhibitor YACG<br /> | **[[4tma]] - SaGyrB C-terminal- + SaGyrA N-terminal + Gyr inhibitor YACG<br /> | ||
| - | **[[5cdn]], [[5cdo]], [[5cdp]], [[6fqv]] – SaGyrA + SaGyrB + DNA<br /> | + | **[[5cdn]], [[5cdo]], [[5cdp]], [[6fqv]], [[6z1a]] – SaGyrA + SaGyrB + DNA<br /> |
**[[6qx2]], [[6qx1]], [[6qtp]], [[6qtk]] – SaGyrA + SaGyrB + DNA + inhibitor<br /> | **[[6qx2]], [[6qx1]], [[6qtp]], [[6qtk]] – SaGyrA + SaGyrB + DNA + inhibitor<br /> | ||
**[[5cdq]], [[6fqm]], [[6fqs]] - SaGyrB + GyrA + DNA + antibiotic<br /> | **[[5cdq]], [[6fqm]], [[6fqs]] - SaGyrB + GyrA + DNA + antibiotic<br /> | ||
| - | **[[5bs3]], [[5iwi]], [[5iwm]] - SaGyrB + GyrA + DNA + inhibitor<br /> | + | **[[5bs3]], [[5iwi]], [[5iwm]], [[6qx2]], [[6qx1]], [[6qtp]], [[6qtk]] - SaGyrB + GyrA + DNA + inhibitor<br /> |
| - | **[[6fm4]] - SaGyrB (mutant) + GyrA + DNA + inhibitor<br /> | + | **[[6fm4]], [[7mvs]] - SaGyrB (mutant) + GyrA + DNA + inhibitor<br /> |
**[[5cdm]] – SaGyrA + SaGyrB (mutant) + DNA<br /> | **[[5cdm]] – SaGyrA + SaGyrB (mutant) + DNA<br /> | ||
**[[5cdr]] – SaGyrA (mutant) + SaGyrB (mutant) + DNA<br /> | **[[5cdr]] – SaGyrA (mutant) + SaGyrB (mutant) + DNA<br /> | ||
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**[[5bs8]], [[5bta]], [[5btd]], [[5btg]], [[5btl]] - MtGyrB + GyrA + DNA + antibiotic<br /> | **[[5bs8]], [[5bta]], [[5btd]], [[5btg]], [[5btl]] - MtGyrB + GyrA + DNA + antibiotic<br /> | ||
**[[5btc]], [[5btf]], [[5bti]], [[5btn]] - MtGyrB + GyrA (mutant) + DNA + antibiotic<br /> | **[[5btc]], [[5btf]], [[5bti]], [[5btn]] - MtGyrB + GyrA (mutant) + DNA + antibiotic<br /> | ||
| + | **[[7ugw]] - MtGyrB + GyrA (mutant) + DNA + inhibitor<br /> | ||
**[[3nuh]] – EcGyrA+EcGyrB<br /> | **[[3nuh]] – EcGyrA+EcGyrB<br /> | ||
**[[6rks]], [[6rku]], [[6rkv]], [[6rkw]] - EcGyrA + GyrB + DNA – Cryo EM<br /> | **[[6rks]], [[6rku]], [[6rkv]], [[6rkw]] - EcGyrA + GyrB + DNA – Cryo EM<br /> | ||
| + | **[[7z9c]], [[7z9g]], [[7z9k]] - EcGyrA + GyrB + DNA + antibiotic – Cryo EM<br /> | ||
*Gyrase | *Gyrase | ||
Current revision
3D Structure of Gyrase
Updated on 27-April-2023
