TRNA-guanine transglycosylase

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (09:03, 18 May 2022) (edit) (undo)
 
(One intermediate revision not shown.)
Line 5: Line 5:
== Structural highlights ==
== Structural highlights ==
TGT overall structure is of a <scene name='55/551184/Cv/5'>Tim barrel</scene>. A structural <scene name='55/551184/Cv/6'>Zn+2 ion is tetrahedrally coordinated</scene> in the C-terminal subdomain. The <scene name='55/551184/Cv/7'>active site contains queuine precursor</scene><ref>PMID:14523925</ref>.
TGT overall structure is of a <scene name='55/551184/Cv/5'>Tim barrel</scene>. A structural <scene name='55/551184/Cv/6'>Zn+2 ion is tetrahedrally coordinated</scene> in the C-terminal subdomain. The <scene name='55/551184/Cv/7'>active site contains queuine precursor</scene><ref>PMID:14523925</ref>.
-
</StructureSection>
 
==3D structures of tRNA-guanine transglycosylase==
==3D structures of tRNA-guanine transglycosylase==
-
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+
[[tRNA-guanine transglycosylase 3D structures]]
-
{{#tree:id=OrganizedByTopic|openlevels=0|
+
-
*tRNA-guanine transglycosylase
+
</StructureSection>
-
 
+
-
**[[6h42]] – hTGT catalytic subunit – human<BR />
+
-
**[[6fv5]] – mTGT non-catalytic subunit – mouse<BR />
+
-
**[[6h62]] – mTGT catalytic subunit <BR />
+
-
**[[1pud]], [[1p0d]], [[4pun]] – ZmTGT – ''Zymomonas mobilis''<BR />
+
-
**[[1wkd]], [[1wke]], [[1wkf]], [[1ozm]], [[2oko]], [[2z1v]], [[2nso]], [[3bl3]], [[3hfy]], [[4gd0]], [[4h6e]], [[3unt]], [[3uvi]], [[4dxx]], [[4dy1]], [[4htb]], [[4ipp]], [[4jbr]], [[4l56]], [[4q8m]], [[4q8n]], [[6h7c]], [[6ygm]], [[6yry]], [[6yfx]], [[6yfw]], [[6z0d]], [[7apm]], [[7apl]] – ZmTGT (mutant)<BR />
+
-
**[[2ash]] – TGT – ''Thermotoga maritima''<BR />
+
-
 
+
-
*tRNA-guanine transglycosylase complexes
+
-
 
+
-
**[[1p0e]] – ZmTGT + preQ1<BR />
+
-
**[[1efz]], [[1pxg]], [[1ozq]], [[2z1x]], [[2nqz]], [[3bld]], [[4gcx]], [[4e2v]] – ZmTGT (mutant) + preQ1<BR />
+
-
**[[3bll]] – ZmTGT (mutant) + preQ1 derivative<BR />
+
-
**[[1p0b]], [[2qii]] – ZmTGT + preQ0<BR />
+
-
**[[2pwv]] – ZmTGT (mutant) + preQ0<BR />
+
-
**[[3blo]], [[4hqv]], [[4hsh]], [[4hvx]] – ZmTGT (mutant) + queuine<BR />
+
-
**[[1enu]], [[1f3e]] – ZmTGT + aminophthalhydrazide<BR />
+
-
**[[1r5y]], [[1q4w]], [[1q63]], [[1q65]], [[1q66]], [[1s38]], [[1s39]], [[1y5v]], [[1y5w]], [[1y5x]], [[2bbf]], [[2qzr]], [[3eos]], [[3eou]], [[3gc4]], [[1k4g]], [[1k4h]], [[3gc5]], [[3ge7]], [[4puj]], [[4puk]], [[4q4o]], [[4q4p]], [[4q4q]], [[4q4r]], [[4q4s]], [[4q8t]], [[4q4u]], [[4q8v]], [[4q8w]], [[5jxq]], [[5jsw]], [[5jxq]], [[5lpo]], [[5lpp]], [[5lpq]], [[5lps]], [[5lpt]], [[3c2y]], [[5i00]], [[5i02]], [[5i03]], [[5i06]], [[5i07]], [[5jgm]], [[5jgo]], [[5jsv]], [[6rkq]], [[6rkt]] – ZmTGT + quinazoline inhibitor<BR />
+
-
**[[4pul]], [[4pum]], [[4q8o]], [[4q8p]], [[4q8q]], [[6fmn]], [[6fpu]], [[6yh3]], [[6h7c]], [[6ygk]], [[6ygl]], [[6ygo]] [[6ygp]], [[6ygs]], [[6ygy]], [[6ygx]], [[6ygw]], [[6ygz]], [[6yh1]], [[6ygr]], [[6yhe]], [[6yiq]], [[6yyz]], [[6yhd]] – ZmTGT (mutant) + quinazoline inhibitor<BR />
+
-
**[[4q4m]] – ZmTGT + triazine inhibitor<BR />
+
-
**[[5egr]], [[5sw3]], [[5v3c]], [[5utj]] – ZmTGT + inhibitor<BR />
+
-
**[[6yh2]] – ZmTGT (mutant) + inhibitor<BR />
+
-
**[[1n2v]], [[2z1w]] – ZmTGT + pyridazine derivative<BR />
+
-
**[[5sw3]], [[6fso]] – ZmTGT + pyridine derivative<BR />
+
-
**[[5utj]] – ZmTGT + azapurine derivative<BR />
+
-
**[[5v3c]] – ZmTGT + cyclohexane derivative<BR />
+
-
**[[1q2r]], [[1q2s]] – ZmTGT + RNA<BR />
+
-
**[[5n6f]] – ZmTGT + guanine<BR />
+
-
**[[2pot]], [[2pwu]], [[4h7z]] – ZmTGT (mutant) + guanine<BR />
+
-
**[[5uti]] – ZmTGT + canavanine<BR />
+
-
**[[2z7k]], [[3rr4]], [[3tll]], [[4fr6]], [[4fsa]], [[4fr1]], [[4fps]], [[4gi4]], [[4giy]], [[4gkt]], [[4kwo]], [[4lbu]], [[4leq]], [[5i09]] – ZmTGT + benzoguanine derivative<BR />
+
-
**[[5j9m]], [[5j9n]], [[5j9o]], [[5jt5]], [[5jt6]], [[5jt7]] – ZmTGT + benzoimidazole derivative<BR />
+
-
**[[3s1g]], [[3sm0]], [[4gg9]], [[4gh1]], [[4gh3]], [[4ghr]] – ZmTGT + benzohypoxanthine derivative<BR />
+
-
**[[6h45]] – hTGT + queuine<BR />
+
-
 
+
-
*Archaebacterial tRNA-guanine transglycosylase
+
-
**[[1iq8]] – PhATGT – ''Pyrococcus horikoshii''<BR />
 
-
**[[1it7]] – PhATGT + guanine<BR />
 
-
**[[1it8]] – PhATGT + preQ0<BR />
 
-
**[[1j2b]] – PhATGT + tRNA-Val<BR />
 
-
}}
 
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Structure of tRNA-guanine transglycosylase complex with queuine precursor and Zn+2 ion (grey) (PDB entry 1p0e)

Drag the structure with the mouse to rotate

References

  1. ↑ Nonekowski ST, Garcia GA. tRNA recognition by tRNA-guanine transglycosylase from Escherichia coli: the role of U33 in U-G-U sequence recognition. RNA. 2001 Oct;7(10):1432-41. PMID:11680848
  2. ↑ Sabina J, Soll D. The RNA-binding PUA domain of archaeal tRNA-guanine transglycosylase is not required for archaeosine formation. J Biol Chem. 2006 Mar 17;281(11):6993-7001. Epub 2006 Jan 10. PMID:16407303 doi:http://dx.doi.org/M512841200
  3. ↑ Brenk R, Stubbs MT, Heine A, Reuter K, Klebe G. Flexible adaptations in the structure of the tRNA-modifying enzyme tRNA-guanine transglycosylase and their implications for substrate selectivity, reaction mechanism and structure-based drug design. Chembiochem. 2003 Oct 6;4(10):1066-77. PMID:14523925 doi:10.1002/cbic.200300644

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

Retrieved from "http://52.214.119.220/wiki/index.php/TRNA-guanine_transglycosylase"
Personal tools