5s88

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(New page: '''Unreleased structure''' The entry 5s88 is ON HOLD Authors: Williams, E.P., Adamson, R.J., Smil, D., Krojer, T., Burgess-Brown, N., von Delft, F., Bountra, C., Bullock, A.N. Descript...)
Current revision (14:16, 6 March 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 5s88 is ON HOLD
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==XChem group deposition -- Crystal Structure of human ACVR1 in complex with FM010954a==
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<StructureSection load='5s88' size='340' side='right'caption='[[5s88]], [[Resolution|resolution]] 1.31&Aring;' scene=''>
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Authors: Williams, E.P., Adamson, R.J., Smil, D., Krojer, T., Burgess-Brown, N., von Delft, F., Bountra, C., Bullock, A.N.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5s88]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5S88 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5S88 FirstGlance]. <br>
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Description: XChem group deposition --Crystal Structure of human ACVR1 in complex with FM010954a
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.31&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=LU8:4-methyl-3-[4-(1-methylpiperidin-4-yl)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridine'>LU8</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=XKS:azetidin-3-ol'>XKS</scene></td></tr>
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[[Category: Adamson, R.J]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5s88 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5s88 OCA], [https://pdbe.org/5s88 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5s88 RCSB], [https://www.ebi.ac.uk/pdbsum/5s88 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5s88 ProSAT]</span></td></tr>
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[[Category: Krojer, T]]
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</table>
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[[Category: Smil, D]]
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== Disease ==
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[[Category: Von Delft, F]]
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[https://www.uniprot.org/uniprot/ACVR1_HUMAN ACVR1_HUMAN] Fibrodysplasia ossificans progressiva. Defects in ACVR1 are a cause of fibrodysplasia ossificans progressiva (FOP) [MIM:[https://omim.org/entry/135100 135100]. FOP is a rare autosomal dominant disorder of skeletal malformations and progressive extraskeletal ossification. Heterotopic ossification in FOP begins in childhood and can be induced by trauma or may occur without warning. Bone formation is episodic and progressive, leading to extra-articular ankylosis of all major joints of the axial and appendicular skeleton, rendering movement impossible.<ref>PMID:16642017</ref> <ref>PMID:19085907</ref> <ref>PMID:19330033</ref>
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[[Category: Williams, E.P]]
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== Function ==
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[[Category: Bountra, C]]
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[https://www.uniprot.org/uniprot/ACVR1_HUMAN ACVR1_HUMAN] On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin. May be involved for left-right pattern formation during embryogenesis (By similarity).
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[[Category: Burgess-Brown, N]]
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== References ==
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[[Category: Bullock, A.N]]
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Adamson RJ]]
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[[Category: Bountra C]]
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[[Category: Bullock AN]]
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[[Category: Burgess-Brown N]]
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[[Category: Krojer T]]
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[[Category: Smil D]]
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[[Category: Williams EP]]
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[[Category: Von Delft F]]

Current revision

XChem group deposition -- Crystal Structure of human ACVR1 in complex with FM010954a

PDB ID 5s88

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