5s8c
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==XChem group deposition -- Crystal Structure of the second bromodomain of pleckstrin homology domain interacting protein (PHIP) in complex with N00322e (space group C2)== | |
| + | <StructureSection load='5s8c' size='340' side='right'caption='[[5s8c]], [[Resolution|resolution]] 1.25Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5s8c]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5S8C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5S8C FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.25Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=RYD:(1-methylbenzotriazol-5-yl)methanol'>RYD</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5s8c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5s8c OCA], [https://pdbe.org/5s8c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5s8c RCSB], [https://www.ebi.ac.uk/pdbsum/5s8c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5s8c ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PHIP_HUMAN PHIP_HUMAN] Probable regulator of the insulin and insulin-like growth factor signaling pathways. Stimulates cell proliferation through regulation of cyclin transcription and has an anti-apoptotic activity through AKT1 phosphorylation and activation. Plays a role in the regulation of cell morphology and cytoskeletal organization.<ref>PMID:12242307</ref> <ref>PMID:21834987</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[WD-repeat protein 3D structures|WD-repeat protein 3D structures]] | |
| - | + | == References == | |
| - | [[Category: | + | <references/> |
| - | [[Category: | + | __TOC__ |
| - | [[Category: Arrowsmith | + | </StructureSection> |
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: Brennan | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Arrowsmith CH]] |
| - | [[Category: | + | [[Category: Bountra C]] |
| - | [[Category: Krojer | + | [[Category: Brennan PE]] |
| - | [[Category: | + | [[Category: Burgess-Brown NA]] |
| - | [[Category: | + | [[Category: Edwards AM]] |
| - | [[Category: | + | [[Category: Fairhead M]] |
| + | [[Category: Krojer T]] | ||
| + | [[Category: Szykowska A]] | ||
| + | [[Category: Talon R]] | ||
| + | [[Category: Von Delft F]] | ||
Current revision
XChem group deposition -- Crystal Structure of the second bromodomain of pleckstrin homology domain interacting protein (PHIP) in complex with N00322e (space group C2)
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