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| | ==NMR solution structure of the putative cation transport regulator ChaB== | | ==NMR solution structure of the putative cation transport regulator ChaB== |
| - | <StructureSection load='1sg7' size='340' side='right'caption='[[1sg7]], [[NMR_Ensembles_of_Models | 17 NMR models]]' scene=''> | + | <StructureSection load='1sg7' size='340' side='right'caption='[[1sg7]]' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[1sg7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SG7 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1SG7 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[1sg7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SG7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SG7 FirstGlance]. <br> |
| - | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CHAB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1sg7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sg7 OCA], [http://pdbe.org/1sg7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1sg7 RCSB], [http://www.ebi.ac.uk/pdbsum/1sg7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1sg7 ProSAT], [http://www.topsan.org/Proteins/BSGI/1sg7 TOPSAN]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1sg7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sg7 OCA], [https://pdbe.org/1sg7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1sg7 RCSB], [https://www.ebi.ac.uk/pdbsum/1sg7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1sg7 ProSAT], [https://www.topsan.org/Proteins/BSGI/1sg7 TOPSAN]</span></td></tr> |
| | </table> | | </table> |
| | + | == Function == |
| | + | [https://www.uniprot.org/uniprot/CHAB_ECO57 CHAB_ECO57] Might be a regulator of the sodium-potassium/proton antiporter ChaA.<ref>PMID:15306028</ref> |
| | == Evolutionary Conservation == | | == Evolutionary Conservation == |
| | [[Image:Consurf_key_small.gif|200px|right]] | | [[Image:Consurf_key_small.gif|200px|right]] |
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| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| - | [[Category: Bacillus coli migula 1895]] | + | [[Category: Escherichia coli]] |
| | [[Category: Large Structures]] | | [[Category: Large Structures]] |
| - | [[Category: Structural genomic]]
| + | [[Category: Cygler M]] |
| - | [[Category: Cygler, M]] | + | [[Category: Gehring K]] |
| - | [[Category: Gehring, K]] | + | [[Category: Osborne MJ]] |
| - | [[Category: Osborne, M J]] | + | [[Category: Siddiqui N]] |
| - | [[Category: Siddiqui, N]] | + | |
| - | [[Category: Bsgi]]
| + | |
| - | [[Category: Unknown function]]
| + | |
| Structural highlights
Function
CHAB_ECO57 Might be a regulator of the sodium-potassium/proton antiporter ChaA.[1]
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
Publication Abstract from PubMed
BACKGROUND: ChaB is a putative regulator of ChaA, a Na+/H+ antiporter that also has Ca+/H+ activity in E. coli. ChaB contains a conserved 60-residue region of unknown function found in other bacteria, archaeabacteria and a series of baculoviral proteins. As part of a structural genomics project, the structure of ChaB was elucidated by NMR spectroscopy. RESULTS: The structure of ChaB is composed of 3 alpha-helices and a small sheet that pack tightly to form a fold that is found in the cyclin-box family of proteins. CONCLUSION: ChaB is distinguished from its putative DNA binding sequence homologues by a highly charged flexible loop region that has weak affinity to Mg2+ and Ca2+ divalent metal ions.
The solution structure of ChaB, a putative membrane ion antiporter regulator from Escherichia coli.,Osborne MJ, Siddiqui N, Iannuzzi P, Gehring K BMC Struct Biol. 2004 Aug 11;4:9. PMID:15306028[2]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Osborne MJ, Siddiqui N, Iannuzzi P, Gehring K. The solution structure of ChaB, a putative membrane ion antiporter regulator from Escherichia coli. BMC Struct Biol. 2004 Aug 11;4:9. PMID:15306028 doi:10.1186/1472-6807-4-9
- ↑ Osborne MJ, Siddiqui N, Iannuzzi P, Gehring K. The solution structure of ChaB, a putative membrane ion antiporter regulator from Escherichia coli. BMC Struct Biol. 2004 Aug 11;4:9. PMID:15306028 doi:10.1186/1472-6807-4-9
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