1sv0

<table><tr><td colspan='2'>[[1sv0]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SV0 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1SV0 FirstGlance]. <br>

</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1sv4|1sv4]]</div></td></tr>

<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">AOP, POK, YAN, CG3166 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME]), Mae ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1sv0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sv0 OCA], [http://pdbe.org/1sv0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1sv0 RCSB], [http://www.ebi.ac.uk/pdbsum/1sv0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1sv0 ProSAT]</span></td></tr>

[[http://www.uniprot.org/uniprot/POK_DROME POK_DROME]] Negative regulator of photoreceptor development that acts antagonistically to the proneural signal mediated by RAS. It acts upstream of SINA to inhibit R7 development.<ref>PMID:1505027</ref> <ref>PMID:1495974</ref>

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== Publication Abstract from PubMed ==

Yan, an ETS family transcriptional repressor, is regulated by receptor tyrosine kinase signaling via the Ras/MAPK pathway. Phosphorylation and downregulation of Yan is facilitated by a protein called Mae. Yan and Mae interact through their SAM domains. We find that repression by Yan requires the formation of a higher order structure mediated by Yan-SAM polymerization. Moreover, a crystal structure of the Yan-SAM/Mae-SAM complex shows that Mae-SAM specifically recognizes a surface on Yan-SAM that is also required for Yan-SAM polymerization. Mae-SAM binds to Yan-SAM with approximately 1000-fold higher affinity than Yan-SAM binds to itself and can effectively depolymerize Yan-SAM. Mutations on Mae that specifically disrupt its SAM domain-dependent interactions with Yan disable the derepression function of Mae in vivo. Depolymerization of Yan by Mae represents a novel mechanism of transcriptional control that sensitizes Yan for regulation by receptor tyrosine kinases.

Derepression by depolymerization; structural insights into the regulation of Yan by Mae.,Qiao F, Song H, Kim CA, Sawaya MR, Hunter JB, Gingery M, Rebay I, Courey AJ, Bowie JU Cell. 2004 Jul 23;118(2):163-73. PMID:15260987<ref>PMID:15260987</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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<div class="pdbe-citations 1sv0" style="background-color:#fffaf0;"></div>

[[Category: Drome]]

[[Category: Bowie, J U]]

[[Category: Courey, A J]]

[[Category: Gingery, M]]

[[Category: Hunter, J B]]

[[Category: Kim, C A]]

[[Category: Qiao, F]]

[[Category: Rebay, I]]

[[Category: Sawaya, M R]]

[[Category: Song, H]]

[[Category: Transcription]]