Tyrosine kinase 3D structures

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*'''Fyn tyrosine kinase''' (Domains: SH3 80-141; SH2 142-247; kinase 260-537)
*'''Fyn tyrosine kinase''' (Domains: SH3 80-141; SH2 142-247; kinase 260-537)
-
**[[1shf]], [[3ua6]] – hTK Fyn SH3 domain – human<br />
+
**[[1shf]], [[3ua6]], [[7a2j]], [[7a2k]] – hTK Fyn SH3 domain – human<br />
-
**[[3h0f]], [[3h0h]], [[3h0i]], [[3cqt]], [[6ipz]], [[6ipy]] - hTK Fyn SH3 domain (mutant)<br />
+
**[[3h0f]], [[3h0h]], [[3h0i]], [[3cqt]], [[6ipz]], [[6ipy]], [[7a2l]], [[7a2m]], [[7a2n]], [[7a2o]], [[7a2p]], [[7a2q]], [[7a2r]],[[7a2s]], [[7a2t]], [[7a2u]], [[7a2v]] - hTK Fyn SH3 domain (mutant)<br />
**[[1zbj]] - hTK Fyn SH3 domain – NMR<br />
**[[1zbj]] - hTK Fyn SH3 domain – NMR<br />
**[[1g83]] - hTK Fyn SH2+SH3 domains (mutant)<br />
**[[1g83]] - hTK Fyn SH2+SH3 domains (mutant)<br />
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**[[3uf4]] – mTK Fyn SH3-SH2 domain – mouse<br />
**[[3uf4]] – mTK Fyn SH3-SH2 domain – mouse<br />
**[[3uf4]] - mTK Fyn SH2+SH3 domains<br />
**[[3uf4]] - mTK Fyn SH2+SH3 domains<br />
-
**[[2l2p]], [[2lp5]] - cTK Fyn SH3 domain (mutant) - chicken - NMR<br />
+
**[[2l2p]], [[2lp5]] - cTK Fyn SH3 domain (mutant)- chicken - NMR<br />
*Fyn complex
*Fyn complex
**[[1fyn]], [[4znx]] - hTK Fyn SH3 domain + peptide<br />
**[[1fyn]], [[4znx]] - hTK Fyn SH3 domain + peptide<br />
-
**[[1nyf]], [[1nyg]], [[1a0n]], [[1azg]] - hTK Fyn SH3 domain + peptide – NMR<br />
+
**[[1a0n]], [[1azg]], [[1nyf]], [[1nyg]] - hTK Fyn SH3 domain + peptide – NMR<br />
-
**[[1efn]], [[1avz]] - hTK Fyn SH3 domain + HIV Nef protein<br />
+
**[[1avz]], [[1efn]] - hTK Fyn SH3 domain + HIV Nef protein<br />
-
**[[4d8d]] - hTK Fyn SH3 domain (mutant) + HIV Nef protein<br />
+
**[[4d8d]], [[7d7s]] - hTK Fyn SH3 domain (mutant) + HIV Nef protein<br />
**[[1m27]] - hTK Fyn SH3 domain + SH2 domain protein 1A + SLAM peptide<br />
**[[1m27]] - hTK Fyn SH3 domain + SH2 domain protein 1A + SLAM peptide<br />
**[[4d8d]] - hTK Fyn SH3 domain (mutant) + HIV Nef protein<br />
**[[4d8d]] - hTK Fyn SH3 domain (mutant) + HIV Nef protein<br />
**[[3ua7]] – hTK Fyn SH3 domain + hepatitis virus peptide<br />
**[[3ua7]] – hTK Fyn SH3 domain + hepatitis virus peptide<br />
**[[4eik]] - hTK Fyn SH3 domain + VSL12 peptide<br />
**[[4eik]] - hTK Fyn SH3 domain + VSL12 peptide<br />
 +
**[[7a2w]], [[7a2x]], [[7a2y]], [[7a2z]] - hTK Fyn SH3 domain (mutant) + VSL12 peptide<br />
**[[1aot]], [[1aou]] - hTK Fyn SH2 domain + phosphopeptide - NMR<BR />
**[[1aot]], [[1aou]] - hTK Fyn SH2 domain + phosphopeptide - NMR<BR />
**[[2dq7]] – hTK kinase domain + staurosporine<br />
**[[2dq7]] – hTK kinase domain + staurosporine<br />
Line 40: Line 41:
**[[5oaz]] - hTK SH3 domain <br />
**[[5oaz]] - hTK SH3 domain <br />
 +
**[[7pw2]] - hTK SH3 domain (mutant) <br />
**[[1ju5]] - hTK SH3 domain (mutant) + CRK SH2 domain + phosphopeptide - NMR<br />
**[[1ju5]] - hTK SH3 domain (mutant) + CRK SH2 domain + phosphopeptide - NMR<br />
**[[1awo]] - hTK SH3 domain + phosphopeptide – NMR<BR />
**[[1awo]] - hTK SH3 domain + phosphopeptide – NMR<BR />
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**[[2o88]] - hTK SH3 domain (mutant} + peptide<br />
**[[2o88]] - hTK SH3 domain (mutant} + peptide<br />
**[[4jjb]], [[4jjc]], [[4jjd]] - hTK abl SH3 domain <br />
**[[4jjb]], [[4jjc]], [[4jjd]] - hTK abl SH3 domain <br />
-
**[[4j9b]], [[3egu]], [[3eg2]], [[3eg3]], [[3eg0]], [[3eg1]] - hTK abl SH3 domain (mutant)<br />
+
**[[3eg0]], [[3eg1]], [[3eg2]], [[3eg3]], [[3egu]], [[4j9b]] - hTK abl SH3 domain (mutant)<br />
**[[4j9c]], [[4j9e]], [[4j9i]] - hTK abl SH3 domain (mutant) + p17 peptide<br />
**[[4j9c]], [[4j9e]], [[4j9i]] - hTK abl SH3 domain (mutant) + p17 peptide<br />
**[[4j9d]], [[4j9f]] - hTK abl SH3 domain (mutant) + p0 peptide<br />
**[[4j9d]], [[4j9f]] - hTK abl SH3 domain (mutant) + p0 peptide<br />
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**[[6bl8]] - hTK kinase domain<br />
**[[6bl8]] - hTK kinase domain<br />
**[[2g2h]] - hTK kinase domain (mutant)<br />
**[[2g2h]] - hTK kinase domain (mutant)<br />
 +
**[[6xr6]], [[6xr7]], [[6xrg]] - hTK kinase domain (mutant) - NMR<br />
**[[2g1t]] - hTK kinase domain + peptide<br />
**[[2g1t]] - hTK kinase domain + peptide<br />
-
**[[2g2i]], [[2g2f]] - hTK kinase domain (mutant) + peptide<br />
+
**[[2g2f]], [[2g2i]] - hTK kinase domain (mutant) + peptide<br />
-
**[[3ue4]], [[3cs9]], [[2hzi]], [[2hz4]], [[2hz0]], [[2hyy]], [[2gqg]], [[4wa9]] - hTK kinase domain + cancer drug<br />
+
**[[2gqg]], [[2hzi]], [[2hz4]], [[2hz0]], [[2hyy]], [[3cs9]], [[3ue4]], [[4wa9]], [[7n9g]] - hTK kinase domain + cancer drug<br />
**[[2f4j]], [[4twp]] - hTK kinase domain (mutant) + cancer drug<br />
**[[2f4j]], [[4twp]] - hTK kinase domain (mutant) + cancer drug<br />
-
**[[3qrk]], [[3qri]], [[3qrj]], [[2v7a]], [[2e2b]], [[2hiw]], [[4zog]], [[5hu9]], [[4yc8]], [[3pyy]], [[6npv]], [[6npu]], [[6npe]] - hTK kinase domain + inhibitor<br />
+
**[[2e2b]], [[2hiw]], [[2v7a]], [[3qrk]], [[3qri]], [[3qrj]], [[4zog]], [[5hu9]], [[4yc8]], [[3pyy]], [[6npv]], [[6npu]], [[6npe]], [[7cc2]], [[7dt2]], [[7w7x]], [[7w7y]] - hTK kinase domain + inhibitor<br />
**[[1opj]], [[1opk]] - mTK kinase domain <br />
**[[1opj]], [[1opk]] - mTK kinase domain <br />
**[[1fpu]], [[1m52]], [[2qoh]], [[3kf4]], [[3kfa]] - mTK kinase domain + inhibitor<br />
**[[1fpu]], [[1m52]], [[2qoh]], [[3kf4]], [[3kfa]] - mTK kinase domain + inhibitor<br />
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**[[2kk1]] – hTK C terminal – NMR<BR />
**[[2kk1]] – hTK C terminal – NMR<BR />
- 
-
*'''Anaplastic lymphoma kinase (Alk)''' or '''Alk tyrosine kinae receptor'''
 
- 
-
**[[4tt7]], [[6cdt]] - hTK kinase domain<br />
 
-
**[[3l9p]], [[3lcs]], [[3lct]], [[2yhv]], [[2yjr]], [[2yjs]], [[4fnw]], [[4fnx]], [[4anl]] - hTK kinase domain (mutant)<br />
 
-
**[[2xb7]], [[2xba]], [[3aox]], [[5imx]], [[5kz0]], [[4ccb]], [[4ccu]], [[4cli]], [[4cmo]], [[4cmt]], [[4cmu]], [[4cnh]], [[4ctb]], [[4ctc]], [[6mx8]], [[6edl]], [[6ebw]], [[6e0r]] - hTK kinase domain + inhibitor<br />
 
-
**[[4dce]], [[4fob]], [[4foc]], [[4fod]], [[4fny]], [[4fnz]], [[4joa]], [[4mkc]], [[4z55]], [[5iug]], [[5iuh]], [[5iui]], [[4cd0]], [[4clj]] - hTK kinase domain (mutant) + inhibitor<br />
 
-
**[[2xp2]], [[6mx8]], [[5fto]], [[5ftq]] - hTK kinase domain + cancer drug<br />
 
-
**[[2yfx]], [[4anq]], [[4ans]], [[5aaa]], [[5aab]], [[5aac]], [[5a9u]], [[5aa8]], [[5aa9]] - hTK kinase domain (mutant) + cancer drug<br />
 
*'''Csk tyrosine kinase'''
*'''Csk tyrosine kinase'''
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**[[3d7t]], [[3d7u]] - hTK kinase domain (mutant) + C-Src<br />
**[[3d7t]], [[3d7u]] - hTK kinase domain (mutant) + C-Src<br />
**[[1k9a]] - TK C terminal - rat<br />
**[[1k9a]] - TK C terminal - rat<br />
 +
 +
*'''Fgr tyrosine kinase'''
 +
 +
**[[7uy0]] - hTK 80-527 + inhibitor<br />
 +
**[[7uy3]] - hTK 80-527 (mutant) + inhibitor<br />
 +
**[[7jt9]] - hTK SH3 domain 77-138<br />
*'''Jak tyrosine kinase''' see [[Janus kinase]]
*'''Jak tyrosine kinase''' see [[Janus kinase]]
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**[[1f2f]] - cTK (mutant) <br />
**[[1f2f]] - cTK (mutant) <br />
**[[1shd]] - cTK + TRKA receptor<br />
**[[1shd]] - cTK + TRKA receptor<br />
-
**[[1f1w]] - cTK (mutant) + peptide<br />
 
**[[1p13]] - cTK + peptide<br />
**[[1p13]] - cTK + peptide<br />
 +
**[[1f1w]] - cTK (mutant) + peptide<br />
**[[1spr]] - RsvTK + phosphate – Rous sarcoma virus<br />
**[[1spr]] - RsvTK + phosphate – Rous sarcoma virus<br />
**[[2jyq]] – RsvTK – NMR<br />
**[[2jyq]] – RsvTK – NMR<br />
-
**[[1kc2]], [[1sps]], [[1is0]], [[1nzl]], [[1nzv]] - RsvTK + peptide<br />
+
**[[1kc2]], [[1is0]], [[1nzl]], [[1nzv]], [[1sps]] - RsvTK + peptide<br />
**[[1sha]], [[1shb]] - RsvTK + phosphopeptide<br />
**[[1sha]], [[1shb]] - RsvTK + phosphopeptide<br />
**[[1qwe]], [[1qwf]] - RsvTK + peptide<br />
**[[1qwe]], [[1qwf]] - RsvTK + peptide<br />
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**[[6c4s]] – hTK + choline kinase peptide<br />
**[[6c4s]] – hTK + choline kinase peptide<br />
-
**[[1jeg]] – mTK + protein-tyrosine phosphatase peptide <br />
+
**[[1jeg]] – mTK + protein-tyrosine phosphatase peptide<br />
**[[1srl]], [[1srm]] - cTK – NMR<br />
**[[1srl]], [[1srm]] - cTK – NMR<br />
**[[3fj5]], [[4jz3]], [[4jz4]], [[6xvo]], [[6xvn]] - cTK<br />
**[[3fj5]], [[4jz3]], [[4jz4]], [[6xvo]], [[6xvn]] - cTK<br />
-
**[[4le9]], [[4oml]], [[4omm]], [[4omn]], [[4omo]], [[4omp]], [[4omq]], [[5i11]], [[4rtu]], [[4rtx]] - cTK (mutant) <br />
+
**[[4le9]], [[4oml]], [[4omm]], [[4omn]], [[4omo]], [[4omp]], [[4omq]], [[4rtu]], [[4rtx]], [[5i11]], [[7a30]], [[7a31]], [[7a32]], [[7a33]], [[7a34]], [[7a35]], [[7a36]], [[7a37]], [[7a38]], [[7a39]], [[7a3a]], [[7a3b]], [[7a3c]], [[7a3d]], [[7a3e]], [[7ner]], [[7nes]], [[7net]] - cTK (mutant) <br />
**[[6xx3]], [[6xx2]], [[6xx5]], [[6xx4]], [[6xx5]], [[6xx2]] - cTK (mutant) + ion<br />
**[[6xx3]], [[6xx2]], [[6xx5]], [[6xx4]], [[6xx5]], [[6xx2]] - cTK (mutant) + ion<br />
-
**[[4hxj]], [[1prl]], [[4qt7]], [[4rty]], [[4rtz]] - cTK + peptide<br />
+
**[[2pri]], [[4hxj]], [[4qt7]], [[4rty]], [[4rtz]] - cTK + peptide<br />
**[[1prm]], [[1rlp]], [[1rlq]], [[1nlo]], [[1nlp]] - cTK + peptide - NMR<br />
**[[1prm]], [[1rlp]], [[1rlq]], [[1nlo]], [[1nlp]] - cTK + peptide - NMR<br />
**[[4hvu]], [[4hvv]], [[4hvw]], [[4rtv]], [[4rtw]], [[5ob2]], [[5ob1]], [[5ob0]], [[5oav]] - cTK (mutant) + peptide<br />
**[[4hvu]], [[4hvv]], [[4hvw]], [[4rtv]], [[4rtw]], [[5ob2]], [[5ob1]], [[5ob0]], [[5oav]] - cTK (mutant) + peptide<br />
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**[[1yo6]] - hTK <br />
**[[1yo6]] - hTK <br />
**[[1yoj]] - hTK (mutant) <br />
**[[1yoj]] - hTK (mutant) <br />
-
**[[2bdf]], [[2bdj]], [[6e6e]], [[6ate]] – hTK + inhibitor<br />
+
**[[2bdf]], [[2bdj]], [[6e6e]], [[6ate]], [[7ng7]] – hTK + inhibitor<br />
**[[1yol]], [[1yom]] – hTK (mutant) + inhibitor<br />
**[[1yol]], [[1yom]] – hTK (mutant) + inhibitor<br />
**[[1byg]] – hTK + staurosporine<br />
**[[1byg]] – hTK + staurosporine<br />
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**[[4mxx]], [[4mxy]], [[4mxz]] – hTK (mutant) + cancer drug<br />
**[[4mxx]], [[4mxy]], [[4mxz]] – hTK (mutant) + cancer drug<br />
**[[3of0]], [[2qi8]] - cTK (mutant) <br />
**[[3of0]], [[2qi8]] - cTK (mutant) <br />
 +
**[[3d7t]], [[3d7u]] – cTK + Csk<br />
 +
**[[3dqw]], [[3dqx]] - cTK (mutant) + ATP<br />
**[[3tz7]], [[3tz8]], [[3tz9]], [[4dgg]] – cTK (mutant) + pyrazolin derivative<br />
**[[3tz7]], [[3tz8]], [[3tz9]], [[4dgg]] – cTK (mutant) + pyrazolin derivative<br />
-
**[[4fic]], [[3uqg]], [[3uqf]], [[3u51]], [[3u4w]], [[4agw]], [[3qlg]], [[3qlf]], [[3g6g]], [[3el8]], [[3f6x]], [[2hwo]], [[2hwp]], [[2oiq]], [[3en4]], [[3en5]], [[3en6]], [[3en7]], [[3el7]], [[5bmm]], [[5j5s]], [[4ybj]], [[4ybk]], [[5xp7]] – cTK + inhibitor<br />
+
**[[4fic]], [[3uqg]], [[3uqf]], [[3u51]], [[3u4w]], [[4agw]], [[3qlg]], [[3qlf]], [[3g6g]], [[3el8]], [[3f6x]], [[2hwo]], [[2hwp]], [[2oiq]], [[3en4]], [[3en5]], [[3en6]], [[3en7]], [[3el7]], [[5bmm]], [[5j5s]], [[4ybj]], [[4ybk]], [[5xp7]], [[7ah3]], [[7d57]], [[7d5o]] – cTK + inhibitor<br />
 +
**[[7wf5]] – cTK + cancer drug<br />
**[[4lgg]], [[4lgh]], [[3svv]], [[3oez]], [[3lok]], [[3g5d]], [[3f3w]], [[3f3v]], [[3geq]], [[3g6h]], [[3f3t]], [[3f3u]], [[2qlq]], [[2qq7]], [[4lgg]], [[4lgh]], [[4mcv]], [[4o2p]], [[5teh]], [[5t0p]], [[5sys]], [[5swh]], [[6hve]], [[6hvf]] – cTK (mutant) + inhibitor<br />
**[[4lgg]], [[4lgh]], [[3svv]], [[3oez]], [[3lok]], [[3g5d]], [[3f3w]], [[3f3v]], [[3geq]], [[3g6h]], [[3f3t]], [[3f3u]], [[2qlq]], [[2qq7]], [[4lgg]], [[4lgh]], [[4mcv]], [[4o2p]], [[5teh]], [[5t0p]], [[5sys]], [[5swh]], [[6hve]], [[6hvf]] – cTK (mutant) + inhibitor<br />
**[[4u5j]] – cTK (mutant) + cancer drug<br />
**[[4u5j]] – cTK (mutant) + cancer drug<br />
-
**[[3d7t]], [[3d7u]] – cTK + Csk<br />
 
-
**[[3dqw]], [[3dqx]] - cTK (mutant) + ATP<br />
 
*Src tyrosine kinase C terminal domain
*Src tyrosine kinase C terminal domain
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**[[1x27]] - hTK Lck SH3-SH2 domain + peptide<br />
**[[1x27]] - hTK Lck SH3-SH2 domain + peptide<br />
**[[1qpj]] - hTK Lck kinase domain + staurosporin<br />
**[[1qpj]] - hTK Lck kinase domain + staurosporin<br />
-
**[[2of2]], [[2of4]], [[2ofu]], [[2ofv]], [[2og8]], [[3b2w]], [[3bym]], [[3bys]], [[3byu]], [[2zm1]], [[2zm4]], [[3byo]], [[2zyb]], [[3ac1]], [[3ac2]], [[3ac3]], [[3ac4]], [[3ac5]], [[3ac8]], [[3acj]], [[3ack]], [[3kmm]], [[3ad4]], [[3ad5]], [[3ad6]], [[1qpc]], [[1qpd]], [[1qpe]], [[6pdj]] - hTK Lck kinase domain + inhibitor<br />
+
**[[1qpc]], [[1qpd]], [[1qpe]], [[2of2]], [[2of4]], [[2ofu]], [[2ofv]], [[2og8]], [[2zm1]], [[2zm4]], [[2zyb]], [[3ac1]], [[3ac2]], [[3ac3]], [[3ac4]], [[3ac5]], [[3ac8]], [[3acj]], [[3ack]], [[3ad4]], [[3ad5]], [[3ad6]], [[3b2w]], [[3bym]], [[3bys]], [[3byu]], [[3byo]], [[3kmm]], [[6pdj]] - hTK Lck kinase domain + inhibitor<br />
**[[3mpm]] - hTK Lck kinase domain (mutant) + inhibitor<br />
**[[3mpm]] - hTK Lck kinase domain (mutant) + inhibitor<br />
**[[4c3f]] - hTK Lck kinase domain (mutant) + chemotype<br />
**[[4c3f]] - hTK Lck kinase domain (mutant) + chemotype<br />
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*'''Syk - spleen tyrosine kinase'''
*'''Syk - spleen tyrosine kinase'''
-
**[[1xba]], [[4xg2]] – hSyk kinase domain
+
**[[1xba]], [[4xg2]] – hSyk kinase domain residues 337-635
*Syk complex
*Syk complex
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**[[1xbb]] - hSyk kinase domain + Gleevec<br />
**[[1xbb]] - hSyk kinase domain + Gleevec<br />
**[[1xbc]] - hSyk kinase domain + staurosporine<br />
**[[1xbc]] - hSyk kinase domain + staurosporine<br />
-
**[[3emg]], [[3fqe]], [[3fqh]], [[3fqs]], [[3srv]], [[4dfl]], [[4dfn]], [[3vf8]], [[3vf9]], [[3tub]], [[3tuc]], [[3tud]], [[4f4p]], [[4fyn]], [[4fyo]], [[4fz6]], [[4fz7]], [[4gfg]], [[4i0r]], [[4i0s]], [[4i0t]], [[4puz]], [[4pv0]], [[4rx7]], [[4rx8]], [[4rx9]], [[5lma]], [[5lmb]], [[5ghv]], [[4wnm]], [[4xg3]], [[4xg4]], [[4xg6]], [[4xg7]], [[4xg8]], [[4xg9]], [[4rss]], [[4yjv]], [[5c26]], [[5c27]], [[4yjo]], [[4yjp]], [[4yjq]], [[4yjr]], [[4yjs]], [[4yjt]], [[4yju]], [[5tr6]], [[5tt7]], [[5tiu]], [[5t68]], [[5y5t]], [[5y5u]], [[4gfg]], [[6hm6]], [[6hm7]], [[6vov]] - hSyk kinase domain + inhibitor<br />
+
**[[3emg]], [[3fqe]], [[3fqh]], [[3fqs]], [[3srv]], [[3tub]], [[3tuc]], [[3tud]], [[3vf8]], [[3vf9]], [[4dfl]], [[4dfn]], [[4f4p]], [[4fyn]], [[4fyo]], [[4fz6]], [[4fz7]], [[4gfg]], [[4i0r]], [[4i0s]], [[4i0t]], [[4puz]], [[4pv0]], [[4rx7]], [[4rx8]], [[4rx9]], [[4wnm]], [[4xg3]], [[4xg4]], [[4xg6]], [[4xg7]], [[4xg8]], [[4xg9]], [[4rss]], [[4yjo]], [[4yjp]], [[4yjq]], [[4yjr]], [[4yjs]], [[4yjt]], [[4yju]], [[4yjv]], [[5c26]], [[5c27]], [[5ghv]], [[5lma]], [[5lmb]], [[5tr6]], [[5tt7]], [[5tiu]], [[5t68]], [[5y5t]], [[5y5u]], [[6hm6]], [[6hm7]], [[6vov]], [[6zc0]], [[6zcp]], [[6zcq]], [[6zcr]], [[6zcs]], [[6zcu]], [[6zcx]], [[6zcy]], [[8bi2]] - hSyk kinase domain + inhibitor<br />
**[[4px6]], [[5cxh]], [[5cxz]], [[5cy3]] - hSyk kinase domain (mutant) + inhibitor<br />
**[[4px6]], [[5cxh]], [[5cxz]], [[5cy3]] - hSyk kinase domain (mutant) + inhibitor<br />
**[[1csy]], [[1csz]] - hSyk SH2 domain + phosphopeptide – NMR<BR />
**[[1csy]], [[1csz]] - hSyk SH2 domain + phosphopeptide – NMR<BR />
**[[4fl1]], [[4fl2]] - hSyk kinase domain + ANP<br />
**[[4fl1]], [[4fl2]] - hSyk kinase domain + ANP<br />
**[[4fl3]] - hSyk kinase domain (mutant) + ANP<br />
**[[4fl3]] - hSyk kinase domain (mutant) + ANP<br />
-
**[[1a81]] – hSyk tandem SH2 domain + T-cell surface peptide <br />
+
**[[7q63]], [[7sa7]] – hSyk tandem SH2 domain <br />
 +
**[[1a81]], [[7q5t]], [[7q5u]], [[7q5w]] – hSyk tandem SH2 domain + T-cell surface peptide <br />
*'''Itk/Tsk tyrosine kinase''' or interleukin-2 tyrosine kinase; domains – SH2 236-344; SH3 160-236; kinase 357-620
*'''Itk/Tsk tyrosine kinase''' or interleukin-2 tyrosine kinase; domains – SH2 236-344; SH3 160-236; kinase 357-620
Line 284: Line 286:
**[[3fzp]] - hTK Pyk2 kinase domain + ATPγS<br />
**[[3fzp]] - hTK Pyk2 kinase domain + ATPγS<br />
-
**[[3fzr]], [[3fzs]], [[3fzt]], [[3h3c]], [[3et7]], [[5to8]], [[5tob]], [[4h1j]], [[4h1m]] - hTK Pyk2 kinase domain + inhibitor<br />
+
**[[3et7]], [[3fzr]], [[3fzs]], [[3fzt]], [[3h3c]], [[4h1j]], [[4h1m]], [[5to8]], [[5tob]] - hTK Pyk2 kinase domain + inhibitor<br />
**[[3gm1]], [[4r32]] - hTK Pyk2 FAT domain + paxillin peptide<br />
**[[3gm1]], [[4r32]] - hTK Pyk2 FAT domain + paxillin peptide<br />
-
**[[4xek]], [[4xev]], [[4xef]] - hTK Pyk2 FAT domain + leupaxin peptide<br />
+
**[[4xef]], [[4xek]], [[4xev]] - hTK Pyk2 FAT domain + leupaxin peptide<br />
**[[4h1j]] - hFAK2 kinase domain + pyrazole inhibitor<br />
**[[4h1j]] - hFAK2 kinase domain + pyrazole inhibitor<br />
**[[3h3c]] - hFAK2 kinase domain + pyrimidine inhibitor<br />
**[[3h3c]] - hFAK2 kinase domain + pyrimidine inhibitor<br />
Line 309: Line 311:
**[[5da3]], [[6cz3]], [[6cz4]] - hTK Ptk6 kinase domain + inhibitor<br />
**[[5da3]], [[6cz3]], [[6cz4]] - hTK Ptk6 kinase domain + inhibitor<br />
**[[5h2u]] - hTK Ptk6 kinase domain (mutant) + cancer drug<br />
**[[5h2u]] - hTK Ptk6 kinase domain (mutant) + cancer drug<br />
 +
 +
*'''Ptk7 tyrosine kinase or inactive tyrosine-protein kinase 7'''
 +
 +
**[[6vg3]] - hTK Ptk7 kinase domain <br />
*'''PtkA tyrosine kinase'''
*'''PtkA tyrosine kinase'''
Line 357: Line 363:
**[[3la6]] - EcTK Wzc kinase domain <br />
**[[3la6]] - EcTK Wzc kinase domain <br />
 +
**[[7ni2]], [[7nib]] - EcTK Wzc – Cryo EM <br />
 +
**[[7dhd]] - VvTK Wzc – Vibrio vulnificus <br />
 +
**[[7dhe]], [[7dhf]] - VvTK Wzc + inhibitor <br />
*'''Ros tyrosine kinase'''
*'''Ros tyrosine kinase'''
Line 371: Line 380:
**[[4oli]] - hTK Tyk2 pseudokinase + kinase domains <br />
**[[4oli]] - hTK Tyk2 pseudokinase + kinase domains <br />
**[[3zon]], [[5c01]], [[5c03]] - hTK Tyk2 pseudokinase domain <br />
**[[3zon]], [[5c01]], [[5c03]] - hTK Tyk2 pseudokinase domain <br />
-
**[[4wov]], [[5tkd]], [[6nzr]], [[6nzq]], [[6nzp]], [[6nzh]], [[6nzf]], [[6nze]], [[6nsl]] - hTK Tyk2 pseudokinase domain + inhibitor<br />
+
**[[4wov]], [[5tkd]], [[6nzr]], [[6nzq]], [[6nzp]], [[6nzh]], [[6nzf]], [[6nze]], [[6nsl]], [[7ax4]], [[7k7o]], [[7k7q]] - hTK Tyk2 pseudokinase domain + inhibitor<br />
**[[4po6]] - hTK Tyk2 SH2+FERM domains + IFNAR1 peptide<br />
**[[4po6]] - hTK Tyk2 SH2+FERM domains + IFNAR1 peptide<br />
Line 396: Line 405:
*'''Ack1 tyrosine kinase''' or activated cdc42 kinase 1
*'''Ack1 tyrosine kinase''' or activated cdc42 kinase 1
-
**[[1u46]], [[4hzr]] - hTK Ack1 kinase domain <br />
+
**[[1u46]], [[4hzr]] - hTK Ack1 kinase domain 115-389<br />
**[[4hzs]] - hTK Ack1 kinase+SH3 domains <br />
**[[4hzs]] - hTK Ack1 kinase+SH3 domains <br />
-
**[[1u4d]], [[3eqp]], [[3eqr]], [[4ewh]], [[4id7]], [[5zxb]] - hTK Ack1 kinase domain + inhibitor<br />
+
**[[1u4d]], [[3eqp]], [[3eqr]], [[4ewh]], [[4id7]], [[5zxb]], [[7kp6]], [[8hmt]] - hTK Ack1 kinase domain + inhibitor<br />
 +
**[[8fe9]] - hTK Ack1 kinase domain (mutant) + inhibitor<br />
 +
 
*'''RECEPTOR TYROSINE KINASES - RTK'''
*'''RECEPTOR TYROSINE KINASES - RTK'''
-
*'''Bruton’s tyrosine kinase Btk''' (Domains: PH 1-170; SH3 216-273; SH2 273-378; kinase 378-659)
+
*Burton’s tyrosine kinase (Domains: PH 1-170; SH3 216-273; SH2 273-378; kinase 378-659)
 +
**[[8gmb]] - hTK Btk <br />
**[[2z0p]] - hTK Btk PH domain<br />
**[[2z0p]] - hTK Btk PH domain<br />
-
**[[1btk]], [[6tt2]], [[6tuh]] – hTK Btk PH domain (mutant) <br />
+
**[[1btk]] – hTK Btk PH domain (mutant) <br />
**[[3p08]], [[1k2p]] - hTK Btk kinase domain<br />
**[[3p08]], [[1k2p]] - hTK Btk kinase domain<br />
**[[1aww]], [[1awx]], [[1qly]] - hTK Btk SH3 domain – NMR<BR />
**[[1aww]], [[1awx]], [[1qly]] - hTK Btk SH3 domain – NMR<BR />
Line 411: Line 423:
**[[4xi2]] - hTK Btk SH3-SH2-kinase domain<br />
**[[4xi2]] - hTK Btk SH3-SH2-kinase domain<br />
**[[4y95]] - bTK Btk kinase domain (mutant) - bovine<br />
**[[4y95]] - bTK Btk kinase domain (mutant) - bovine<br />
-
**[[4y93]] - bTK Btk PH+kinase domains (mutant) <br />
+
**[[4y93]], [[8s93]] - bTK Btk PH+kinase domains (mutant) <br />
*Btk complex
*Btk complex
**[[1b55]] - hTK Btk PH domain + inositol-tetrakisphosphate<br />
**[[1b55]] - hTK Btk PH domain + inositol-tetrakisphosphate<br />
-
**[[6tse]], [[6tvn]] - hTK Btk PH domain (mutant) + indoline derivative<br />
 
**[[1bwn]] - hTK Btk PH domain (mutant) + inositol-tetrakisphosphate<br />
**[[1bwn]] - hTK Btk PH domain (mutant) + inositol-tetrakisphosphate<br />
-
**[[3gen]], [[3ocs]], [[3pix]], [[3piy]], [[3piz]], [[3pj1]], [[3pj2]], [[3pj3]], [[4nwm]], [[4yhf]], [[5jrs]], [[5fbo]], [[5fbn]], [[4rx5]], [[5bpy]], [[5bq0]], [[5vgo]], [[5u9d]], [[5t18]], [[5p9m]], [[5p9l]], [[5p9m]], [[5p9l]], [[5p9f]], [[5p9g]], [[5p9h]], [[5p9i]], [[5p9j]], [[5p9k]], [[5vfi]], [[4z3v]], [[4zly]], [[4zlz]], [[5zz4]], [[6aua]], [[6aub]], [[5j87]], [[5xyz]], [[6bik]], [[6bke]], [[6bkh]], [[6bkw]], [[6bln]], [[6di0]], [[6di1]], [[6di3]], [[6di5]], [[6di9]], [[6e4f]], [[6e9p]], [[5kup]], [[6tfp]], [[6s90]], [[6o8i]], [[6nzm]], [[6nfi]], [[6nfh]], [[6n9p]], [[6w07]], [[6w06]], [[6vxq]], [[6o8i]] - hTK Btk kinase domain + inhibitor<br />
+
**[[6yyf]], [[6yyg]], [[6yyk]] - hTK Btk PH domain (mutant) + inhibitor<br />
-
**[[3k54]], [[3t9t]], [[4ot5]], [[4ot6]], [[4otq]], [[4otr]], [[4otf]], [[4rfy]], [[4rfz]], [[4rg0]], [[6ep9]], [[6hrt]], [[6hrp]] - hTK Btk kinase domain (mutant) + inhibitor<br />
+
**[[3gen]], [[3ocs]], [[3pix]], [[3piy]], [[3piz]], [[3pj1]], [[3pj2]], [[3pj3]], [[4nwm]], [[4rx5]], [[4yhf]], [[4z3v]], [[4zly]], [[4zlz]], [[5bpy]], [[5bq0]], [[5fbn]], [[5fbo]], [[5j87]], [[5jrs]], [[5kup]], [[5p9f]], [[5p9g]], [[5p9h]], [[5p9i]], [[5p9j]], [[5p9k]], [[5p9l]], [[5p9m]], [[5t18]], [[5u9d]], [[5vfi]], [[5vgo]], [[5xyz]], [[5zz4]], [[6aua]], [[6aub]], [[6bik]], [[6bke]], [[6bkh]], [[6bkw]], [[6bln]], [[6di0]], [[6di1]], [[6di3]], [[6di5]], [[6di9]], [[6e4f]], [[6e9p]], [[6n9p]], [[6nzm]], [[6nfh]], [[6nfi]], [[6o8i]], [[6s90]], [[6tfp]], [[6vxq]], [[6w06]], [[6w07]], [[6x3n]], [[6x3o]], [[6x3p]], [[6xe4]], [[7kxl]], [[7kxm]], [[7kxn]], [[7kxo]], [[7kxp]], [[7kxq]], [[7lty]], [[7ltz]], [[7n4q]], [[7n4r]], [[7n4s]], [[7n5o]], [[7n5r]], [[7n5x]], [[7n5y]], [[7r60]], [[7r61]], [[7yc9]], [[8e2m]], [[8ejb]], [[8flg]], [[8flh]], [[8flv]], [[8gc7]] - hTK Btk kinase domain + inhibitor<br />
-
**[[5vgo]], [[6omu]], [[6j6m]] - hTK Btk kinase domain + cancer drug<br />
+
**[[3k54]], [[3t9t]], [[4ot5]], [[4ot6]], [[4otq]], [[4otr]], [[4otf]], [[4rfy]], [[4rfz]], [[4rg0]], [[6ep9]], [[6hrt]], [[6hrp]], [[8ff0]], [[8gc8]] - hTK Btk kinase domain (mutant) + inhibitor<br />
-
**[[3oct]] - hTK Btk kinase domain (mutant) + cancer drug<br />
+
**[[6w7o]], [[6w8i]], [[8dso]] - hTK Btk kinase domain + cIAP + inhibitor<br />
 +
**[[5vgo]], [[7l5o]], [[7l5p]], [[8fll]], [[8u2d]], [[8u2e]] - hTK Btk kinase domain + cancer drug<br />
 +
**[[3oct]], [[8fd9]], [[8fln]] - hTK Btk kinase domain (mutant) + cancer drug<br />
**[[6omu]] - hTK Btk kinase domain + MS drug<br />
**[[6omu]] - hTK Btk kinase domain + MS drug<br />
**[[6j6m]] - hTK Btk kinase domain + MCL drug<br />
**[[6j6m]] - hTK Btk kinase domain + MCL drug<br />
Line 428: Line 441:
*'''c-FMS tyrosine kinase or macrophage colony-stimulating factor 1 receptor''' see [[Colony-stimulating factor receptor]]
*'''c-FMS tyrosine kinase or macrophage colony-stimulating factor 1 receptor''' see [[Colony-stimulating factor receptor]]
- 
-
*'''DDR1 and DDR2 tyrosine kinase receptors''' see [[Epithelial discoidin domain-containing receptor]]
 
*'''Kit tyrosine kinase''' or mast/stem cell growth factor receptor Kit; Domains – extracellular 1-519; kinase 547-693, 754-935
*'''Kit tyrosine kinase''' or mast/stem cell growth factor receptor Kit; Domains – extracellular 1-519; kinase 547-693, 754-935
Line 437: Line 448:
**[[2e9w]] - hTK Kit extracellular domain + stem cell factor<br />
**[[2e9w]] - hTK Kit extracellular domain + stem cell factor<br />
**[[1t45]], [[4pgz]] - hTK Kit kinase domain<br />
**[[1t45]], [[4pgz]] - hTK Kit kinase domain<br />
-
**[[1t46]], [[4u0i]], [[6mob]], [[6kla]] - hTK Kit kinase domain + cancer drug<br />
+
**[[1t46]], [[4u0i]], [[6kia]], [[6mob]] - hTK Kit kinase domain + cancer drug<br />
-
**[[6gqj]], [[6gql]], [[6gqm]], [[6gqk]] - hTK Kit kinase domain (mutant) + cancer drug<br />
+
**[[6gqj]], [[6gqk]], [[6gql]], [[6gqm]] - hTK Kit kinase domain (mutant) + cancer drug<br />
-
**[[6itv]], [[6itt]] - hTK Kit kinase domain + inhibitor<br />
+
**[[6itv]], [[6itt]], [[6xv9]], [[6xva]], [[6xvb]], [[7khg]], [[7khj]], [[7khk]] - hTK Kit kinase domain + inhibitor<br />
**[[4hvs]], [[6hh1]] - hTK Kit kinase domain (mutant) + inhibitor<br />
**[[4hvs]], [[6hh1]] - hTK Kit kinase domain (mutant) + inhibitor<br />
**[[2o26]] - hTK Kit residues 25-314 + Kit ligand<br />
**[[2o26]] - hTK Kit residues 25-314 + Kit ligand<br />
Line 447: Line 458:
**[[2dbj]] - hTK Mer FN3 domain – NMR<BR />
**[[2dbj]] - hTK Mer FN3 domain – NMR<BR />
-
**[[2p0c]] - hTK Mer kinase domain
+
**[[2p0c]] - hTK Mer kinase domain<br />
*Mer complex
*Mer complex
Line 454: Line 465:
**[[3brb]] - hTK Mer kinase domain + ADP<br />
**[[3brb]] - hTK Mer kinase domain + ADP<br />
**[[2p0c]] - hTK Mer kinase domain + ANP<br />
**[[2p0c]] - hTK Mer kinase domain + ANP<br />
-
**[[3bpr]], [[3tcp]], [[4m3q]], [[4mh7]], [[4mha]], [[5u6c]], [[5tc0]], [[5k0k]], [[5k0x]], [[5td2]], [[6mep]] - hTK Mer kinase domain + inhibitor<br />
+
**[[3bpr]], [[3tcp]], [[4m3q]], [[4mh7]], [[4mha]], [[5k0k]], [[5k0x]], [[5tc0]], [[5td2]], [[5u6c]], [[6mep]], [[7avx]], [[7aw4]], [[7cqe]], [[7m5z]], [[7oam]], [[7ols]], [[7olv]], [[7olx]] - hTK Mer kinase domain + inhibitor<br />
-
**[[7ab2]], [[7aax]], [[7aaz]] - hTK Mer kinase domain (mutant) + inhibitor<br />
+
**[[7ab2]], [[7aax]], [[7aaz]], [[7avy]], [[7avz]], [[7aw0]], [[7aw1]], [[7aw2]], [[7aw3]], [[7dxl]], [[7xhy]] - hTK Mer kinase domain (mutant) + inhibitor<br />
**[[7ab1]] - hTK Mer kinase domain + anti-cancer drug<br />
**[[7ab1]] - hTK Mer kinase domain + anti-cancer drug<br />
**[[7aay]] - hTK Mer kinase domain (mutant) + anti-cancer drug<br />
**[[7aay]] - hTK Mer kinase domain (mutant) + anti-cancer drug<br />
Line 470: Line 481:
*'''ErbB tyrosine kinase''' see [[Epidermal Growth Factor Receptor]]
*'''ErbB tyrosine kinase''' see [[Epidermal Growth Factor Receptor]]
- 
-
*'''MuSK tyrosine kinase'''
 
- 
-
**[[3hkl]] - rTK MuSK Fz-Crd domain <br />
 
-
**[[1luf]], [[2iep]] - rTK MuSK cytoplasmic domain <br />
 
*'''Sgk223 tyrosine kinase or sugen kinase'''
*'''Sgk223 tyrosine kinase or sugen kinase'''
Line 483: Line 489:
**[[3us4]] - hTK Matk SH2 domain <br />
**[[3us4]] - hTK Matk SH2 domain <br />
-
 
+
**[[1x6g]] - hTK Matk SH3 domain - NMR<br />
-
*'''Cbl-c tyrosine kinase'''
+
-
 
+
-
**[[3vro]] - hTK Cbl-c kinase domain + Src peptide<br />
+
-
**[[3vrp]] - hTK Cbl-c kinase domain + EGRF peptide<br />
+
-
**[[3vrr]] - hTK Cbl-c kinase domain (mutant) + EGRF peptide<br />
+
*'''Flt3 tyrosine kinase'''
*'''Flt3 tyrosine kinase'''
**[[1rjb]] - hTK Flt3 kinase domain <br />
**[[1rjb]] - hTK Flt3 kinase domain <br />
-
**[[4rt7]], [[6il3]], [[5x02]] - hTK Flt3 kinase domain + inhibitor<br />
+
**[[4rt7]], [[5x02]], [[6il3]] - hTK Flt3 kinase domain + inhibitor<br />
 +
**[[6jqr]] - hTK Flt3 kinase domain + leukemia drug<br /
**[[4xuf]] - hTK Flt3 kinase domain (mutant) + leukemia drug<br />
**[[4xuf]] - hTK Flt3 kinase domain (mutant) + leukemia drug<br />
 +
**[[3qs7]], [[3qs9]] - hTK Flt3 kinase domain + SL cytokine<br /
*'''Tie2 tyrosine kinase'''
*'''Tie2 tyrosine kinase'''
Line 500: Line 503:
**[[1fvr]] - hTK Tie2 kinase domain <br />
**[[1fvr]] - hTK Tie2 kinase domain <br />
-
*'''Ret tyrosine kinase''' or '''proto-oncogene tyrosine protein kinase receptor Ret'''
+
*'''DDR1 and DDR2 tyrosine kinase receptors''' see [[Epithelial discoidin domain-containing receptor]]
-
 
+
-
**[[6nja]] - hTK Ret kinase domain<br />
+
-
**[[6fek]] - hTK Ret kinase domain (mutant)<br />
+
-
**[[5amn]], [[6vhg]] - hTK Ret kinase domain + inhibitor<br />
+
-
**[[6i83]], [[6i82]] - hTK Ret kinase domain (mutant) + inhibitor<br />
+
-
**[[6nec]], [[6ne7]], [[7ju5]] - hTK Ret kinase domain + cancer drug<br />
+
-
**[[4ux8]] - hTK Ret extracellular domain + GFR α 1<br />
+
-
**[[6gl7]] - hTK Ret extracellular domain + GFR α 2 + neurturin - Cryo EM<br />
+
-
 
+
*'''c-Met tyrosine kinase''' see [[Hepatocyte growth factor receptor]]
*'''c-Met tyrosine kinase''' see [[Hepatocyte growth factor receptor]]

Current revision

3D structures of tyrosine kinase

Updated on 01-March-2024 - For a general description of the protein see Tyrosine kinase


Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman

Retrieved from "http://52.214.119.220/wiki/index.php/Tyrosine_kinase_3D_structures"
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