1dec

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[[Image:1dec.gif|left|200px]]
 
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==STRUCTURE OF THE RGD PROTEIN DECORSIN: CONSERVED MOTIF AND DISTINCT FUNCTION IN LEECH PROTEINS THAT AFFECT BLOOD CLOTTING==
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The line below this paragraph, containing "STRUCTURE_1dec", creates the "Structure Box" on the page.
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<StructureSection load='1dec' size='340' side='right'caption='[[1dec]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1dec]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Macrobdella_decora Macrobdella decora]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DEC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DEC FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 25 models</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dec FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dec OCA], [https://pdbe.org/1dec PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dec RCSB], [https://www.ebi.ac.uk/pdbsum/1dec PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dec ProSAT]</span></td></tr>
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{{STRUCTURE_1dec| PDB=1dec | SCENE= }}
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</table>
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== Function ==
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'''STRUCTURE OF THE RGD PROTEIN DECORSIN: CONSERVED MOTIF AND DISTINCT FUNCTION IN LEECH PROTEINS THAT AFFECT BLOOD CLOTTING'''
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[https://www.uniprot.org/uniprot/DECO_MACDE DECO_MACDE] Inhibits fibrinogen interaction with platelet receptors expressed on glycoprotein IIb-IIIa complex. May prevent blood from clotting during either feeding and/or storage of ingested blood.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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==Overview==
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The structure of the leech protein decorsin, a potent 39-residue antagonist of glycoprotein IIb-IIIa and inhibitor of platelet aggregation, was determined by nuclear magnetic resonance. In contrast to other disintegrins, the Arg-Gly-Asp (RGD)-containing region of decorsin is well defined. The three-dimensional structure of decorsin is similar to that of hirudin, an anticoagulant leech protein that potently inhibits thrombin. Amino acid sequence comparisons suggest that ornatin, another glycoprotein IIb-IIIa antagonist, and antistasin, a potent Factor Xa inhibitor and anticoagulant found in leeches, share the same structural motif. Although decorsin, hirudin, and antistasin all affect the blood clotting process and appear similar in structure, their mechanisms of action and epitopes important for binding to their respective targets are distinct.
The structure of the leech protein decorsin, a potent 39-residue antagonist of glycoprotein IIb-IIIa and inhibitor of platelet aggregation, was determined by nuclear magnetic resonance. In contrast to other disintegrins, the Arg-Gly-Asp (RGD)-containing region of decorsin is well defined. The three-dimensional structure of decorsin is similar to that of hirudin, an anticoagulant leech protein that potently inhibits thrombin. Amino acid sequence comparisons suggest that ornatin, another glycoprotein IIb-IIIa antagonist, and antistasin, a potent Factor Xa inhibitor and anticoagulant found in leeches, share the same structural motif. Although decorsin, hirudin, and antistasin all affect the blood clotting process and appear similar in structure, their mechanisms of action and epitopes important for binding to their respective targets are distinct.
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==About this Structure==
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Structure of the RGD protein decorsin: conserved motif and distinct function in leech proteins that affect blood clotting.,Krezel AM, Wagner G, Seymour-Ulmer J, Lazarus RA Science. 1994 Jun 24;264(5167):1944-7. PMID:8009227<ref>PMID:8009227</ref>
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1DEC is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Macrobdella_decora Macrobdella decora]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DEC OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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Structure of the RGD protein decorsin: conserved motif and distinct function in leech proteins that affect blood clotting., Krezel AM, Wagner G, Seymour-Ulmer J, Lazarus RA, Science. 1994 Jun 24;264(5167):1944-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8009227 8009227]
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</div>
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<div class="pdbe-citations 1dec" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Macrobdella decora]]
[[Category: Macrobdella decora]]
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[[Category: Single protein]]
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[[Category: Krezel AM]]
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[[Category: Krezel, A M.]]
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[[Category: Lazarus RA]]
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[[Category: Lazarus, R A.]]
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[[Category: Seymour-Ulmer J]]
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[[Category: Seymour-Ulmer, J.]]
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[[Category: Wagner G]]
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[[Category: Wagner, G.]]
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[[Category: Blood coagulation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 13:45:26 2008''
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Current revision

STRUCTURE OF THE RGD PROTEIN DECORSIN: CONSERVED MOTIF AND DISTINCT FUNCTION IN LEECH PROTEINS THAT AFFECT BLOOD CLOTTING

PDB ID 1dec

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