1ug8
From Proteopedia
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==NMR structure of the R3H domain from Poly(A)-specific Ribonuclease== | ==NMR structure of the R3H domain from Poly(A)-specific Ribonuclease== | ||
| - | <StructureSection load='1ug8' size='340' side='right'caption='[[1ug8 | + | <StructureSection load='1ug8' size='340' side='right'caption='[[1ug8]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1ug8]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[1ug8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UG8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UG8 FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ug8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ug8 OCA], [https://pdbe.org/1ug8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ug8 RCSB], [https://www.ebi.ac.uk/pdbsum/1ug8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ug8 ProSAT], [https://www.topsan.org/Proteins/RSGI/1ug8 TOPSAN]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/PARN_MOUSE PARN_MOUSE] 3'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs and is also used to silence certain maternal mRNAs translationally during oocyte maturation and early embryonic development. Interacts with both the 3'-end poly(A) tail and the 5'-end cap structure during degradation, the interaction with the cap structure being required for an efficient degradation of poly(A) tails. Involved in nonsense-mediated mRNA decay, a critical process of selective degradation of mRNAs that contain premature stop codons. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly via its interaction with KHSRP. Probably mediates the removal of poly(A) tails of AREs mRNAs, which constitutes the first step of destabilization (By similarity). |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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==See Also== | ==See Also== | ||
*[[Ribonuclease 3D structures|Ribonuclease 3D structures]] | *[[Ribonuclease 3D structures|Ribonuclease 3D structures]] | ||
| - | *[[Temp|Temp]] | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Mus musculus]] |
| - | [[Category: Aoki | + | [[Category: Aoki M]] |
| - | [[Category: Arakawa | + | [[Category: Arakawa T]] |
| - | [[Category: Carninci | + | [[Category: Carninci P]] |
| - | [[Category: Hayami | + | [[Category: Hayami N]] |
| - | [[Category: Hayashizaki | + | [[Category: Hayashizaki Y]] |
| - | [[Category: Hirota | + | [[Category: Hirota H]] |
| - | [[Category: Inoue | + | [[Category: Inoue M]] |
| - | [[Category: Kawai | + | [[Category: Kawai J]] |
| - | [[Category: Kigawa | + | [[Category: Kigawa T]] |
| - | [[Category: Kobayashi | + | [[Category: Kobayashi N]] |
| - | [[Category: Matsuda | + | [[Category: Matsuda T]] |
| - | [[Category: Matsuo | + | [[Category: Matsuo Y]] |
| - | [[Category: Muto | + | [[Category: Muto Y]] |
| - | [[Category: Nagata | + | [[Category: Nagata T]] |
| - | [[Category: Osanai | + | [[Category: Osanai T]] |
| - | + | [[Category: Seki E]] | |
| - | [[Category: Seki | + | [[Category: Shirouzu M]] |
| - | [[Category: Shirouzu | + | [[Category: Tanaka A]] |
| - | [[Category: Tanaka | + | [[Category: Terada T]] |
| - | [[Category: Terada | + | [[Category: Uda H]] |
| - | [[Category: Uda | + | [[Category: Yabuki T]] |
| - | [[Category: Yabuki | + | [[Category: Yokoyama S]] |
| - | [[Category: Yokoyama | + | [[Category: Yoshida M]] |
| - | [[Category: Yoshida | + | |
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Current revision
NMR structure of the R3H domain from Poly(A)-specific Ribonuclease
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Categories: Large Structures | Mus musculus | Aoki M | Arakawa T | Carninci P | Hayami N | Hayashizaki Y | Hirota H | Inoue M | Kawai J | Kigawa T | Kobayashi N | Matsuda T | Matsuo Y | Muto Y | Nagata T | Osanai T | Seki E | Shirouzu M | Tanaka A | Terada T | Uda H | Yabuki T | Yokoyama S | Yoshida M
