1ujy

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==Solution structure of SH3 domain in Rac/Cdc42 guanine nucleotide exchange factor(GEF) 6==
==Solution structure of SH3 domain in Rac/Cdc42 guanine nucleotide exchange factor(GEF) 6==
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<StructureSection load='1ujy' size='340' side='right'caption='[[1ujy]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='1ujy' size='340' side='right'caption='[[1ujy]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1ujy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UJY OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1UJY FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1ujy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UJY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UJY FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">KAZUSA ha01154 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1ujy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ujy OCA], [http://pdbe.org/1ujy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ujy RCSB], [http://www.ebi.ac.uk/pdbsum/1ujy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1ujy ProSAT], [http://www.topsan.org/Proteins/RSGI/1ujy TOPSAN]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ujy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ujy OCA], [https://pdbe.org/1ujy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ujy RCSB], [https://www.ebi.ac.uk/pdbsum/1ujy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ujy ProSAT], [https://www.topsan.org/Proteins/RSGI/1ujy TOPSAN]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/ARHG6_HUMAN ARHG6_HUMAN]] Defects in ARHGEF6 are the cause of mental retardation X-linked type 46 (MRX46) [MIM:[http://omim.org/entry/300436 300436]]. Mental retardation is a mental disorder characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Non-syndromic mental retardation patients do not manifest other clinical signs.<ref>PMID:11017088</ref>
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[https://www.uniprot.org/uniprot/ARHG6_HUMAN ARHG6_HUMAN] Defects in ARHGEF6 are the cause of mental retardation X-linked type 46 (MRX46) [MIM:[https://omim.org/entry/300436 300436]. Mental retardation is a mental disorder characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Non-syndromic mental retardation patients do not manifest other clinical signs.<ref>PMID:11017088</ref>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/ARHG6_HUMAN ARHG6_HUMAN]] Acts as a RAC1 guanine nucleotide exchange factor (GEF).
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[https://www.uniprot.org/uniprot/ARHG6_HUMAN ARHG6_HUMAN] Acts as a RAC1 guanine nucleotide exchange factor (GEF).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Aoki, M]]
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[[Category: Aoki M]]
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[[Category: He, F]]
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[[Category: He F]]
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[[Category: Hirota, H]]
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[[Category: Hirota H]]
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[[Category: Inoue, M]]
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[[Category: Inoue M]]
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[[Category: Kigawa, T]]
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[[Category: Kigawa T]]
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[[Category: Kikuno, R]]
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[[Category: Kikuno R]]
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[[Category: Kobayashi, N]]
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[[Category: Kobayashi N]]
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[[Category: Koshiba, S]]
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[[Category: Koshiba S]]
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[[Category: Matsuda, T]]
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[[Category: Matsuda T]]
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[[Category: Matsuo, Y]]
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[[Category: Matsuo Y]]
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[[Category: Muto, Y]]
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[[Category: Muto Y]]
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[[Category: Nagase, T]]
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[[Category: Nagase T]]
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[[Category: Nagayama, M]]
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[[Category: Nagayama M]]
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[[Category: Ohara, O]]
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[[Category: Ohara O]]
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[[Category: Osanai, T]]
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[[Category: Osanai T]]
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[[Category: Structural genomic]]
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[[Category: Seki E]]
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[[Category: Seki, E]]
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[[Category: Shirouzu M]]
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[[Category: Shirouzu, M]]
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[[Category: Tanaka A]]
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[[Category: Tanaka, A]]
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[[Category: Terada T]]
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[[Category: Terada, T]]
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[[Category: Uda H]]
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[[Category: Uda, H]]
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[[Category: Yabuki T]]
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[[Category: Yabuki, T]]
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[[Category: Yokoyama S]]
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[[Category: Yokoyama, S]]
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[[Category: Yoshida M]]
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[[Category: Yoshida, M]]
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[[Category: Gef 6]]
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[[Category: Rsgi]]
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[[Category: Sh3 domain]]
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[[Category: Signaling protein]]
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Current revision

Solution structure of SH3 domain in Rac/Cdc42 guanine nucleotide exchange factor(GEF) 6

PDB ID 1ujy

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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