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2fmu
From Proteopedia
(Difference between revisions)
(New page: 200px<br /> <applet load="2fmu" size="450" color="white" frame="true" align="right" spinBox="true" caption="2fmu, resolution 2.300Å" /> '''Crystal structure ...) |
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| - | [[Image:2fmu.gif|left|200px]]<br /> | ||
| - | <applet load="2fmu" size="450" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="2fmu, resolution 2.300Å" /> | ||
| - | '''Crystal structure of Tat-interacting protein 30 kDa (HIV-1 tat interactive protein 2, 30 kDa homolog) (Human) (16924205) from Mus musculus at 2.30 A resolution'''<br /> | ||
| - | == | + | ==Crystal structure of a tat-interacting protein homologue (htatip2, aw111545, cc3, tip30) from mus musculus at 2.30 A resolution== |
| - | + | <StructureSection load='2fmu' size='340' side='right'caption='[[2fmu]], [[Resolution|resolution]] 2.30Å' scene=''> | |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[2fmu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FMU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FMU FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fmu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fmu OCA], [https://pdbe.org/2fmu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fmu RCSB], [https://www.ebi.ac.uk/pdbsum/2fmu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fmu ProSAT], [https://www.topsan.org/Proteins/JCSG/2fmu TOPSAN]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/HTAI2_MOUSE HTAI2_MOUSE] Oxidoreductase required for tumor suppression. NADPH-bound form inhibits nuclear import by competing with nuclear import substrates for binding to a subset of nuclear transport receptors. May act as a redox sensor linked to transcription through regulation of nuclear import.<ref>PMID:14695192</ref> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fm/2fmu_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2fmu ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
| - | [[Category: Single protein]] | ||
| - | [[Category: JCSG, Joint.Center.for.Structural.Genomics.]] | ||
| - | [[Category: EDO]] | ||
| - | [[Category: 16924205]] | ||
| - | [[Category: 30 kda homolog) (human)]] | ||
| - | [[Category: jcsg]] | ||
| - | [[Category: joint center for structural genomics]] | ||
| - | [[Category: protein structure initiative]] | ||
| - | [[Category: psi]] | ||
| - | [[Category: structural genomics]] | ||
| - | [[Category: tat-interacting protein 30 kda (hiv-1 tat interactive protein 2]] | ||
| - | |||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Thu Nov 8 14:47:50 2007'' | ||
Current revision
Crystal structure of a tat-interacting protein homologue (htatip2, aw111545, cc3, tip30) from mus musculus at 2.30 A resolution
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