1wi0

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==Solution structure of the PB1 domain of mouse mitogen activated protein kinase kinase 5 (MAP2K5)==
==Solution structure of the PB1 domain of mouse mitogen activated protein kinase kinase 5 (MAP2K5)==
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<StructureSection load='1wi0' size='340' side='right'caption='[[1wi0]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='1wi0' size='340' side='right'caption='[[1wi0]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1wi0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WI0 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1WI0 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1wi0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WI0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WI0 FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RIKEN cDNA A230106F01 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1wi0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wi0 OCA], [http://pdbe.org/1wi0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1wi0 RCSB], [http://www.ebi.ac.uk/pdbsum/1wi0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1wi0 ProSAT], [http://www.topsan.org/Proteins/RSGI/1wi0 TOPSAN]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wi0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wi0 OCA], [https://pdbe.org/1wi0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wi0 RCSB], [https://www.ebi.ac.uk/pdbsum/1wi0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wi0 ProSAT], [https://www.topsan.org/Proteins/RSGI/1wi0 TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/MP2K5_MOUSE MP2K5_MOUSE]] Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis.<ref>PMID:10473620</ref> <ref>PMID:16507987</ref>
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[https://www.uniprot.org/uniprot/MP2K5_MOUSE MP2K5_MOUSE] Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis.<ref>PMID:10473620</ref> <ref>PMID:16507987</ref>
==See Also==
==See Also==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Lk3 transgenic mice]]
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[[Category: Mus musculus]]
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[[Category: Hayashi, F]]
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[[Category: Hayashi F]]
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[[Category: Inoue, M]]
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[[Category: Inoue M]]
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[[Category: Kigawa, T]]
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[[Category: Kigawa T]]
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[[Category: Koshiba, S]]
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[[Category: Koshiba S]]
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[[Category: Structural genomic]]
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[[Category: Tochio N]]
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[[Category: Tochio, N]]
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[[Category: Yokoyama S]]
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[[Category: Yokoyama, S]]
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[[Category: Yoneyama M]]
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[[Category: Yoneyama, M]]
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[[Category: Cytoplasmic signalling]]
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[[Category: Pb1 domain]]
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[[Category: Protein-protein interaction site]]
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[[Category: Rsgi]]
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[[Category: Transferase]]
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Current revision

Solution structure of the PB1 domain of mouse mitogen activated protein kinase kinase 5 (MAP2K5)

PDB ID 1wi0

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