Tyrosine phosphatase 3D structures
From Proteopedia
(Difference between revisions)
(17 intermediate revisions not shown.) | |||
Line 6: | Line 6: | ||
*'''Class I''' | *'''Class I''' | ||
- | *'''Non-receptor type tyrosine phosphatase''' | + | *'''Non-receptor type tyrosine phosphatase; Domains – catalytic 1-321;''' |
- | **[[ | + | **[[8u1e]] - hPTP-1b catalytic domain - human<br /> |
- | **[[ | + | **[[1a5y]], [[2hnp]], [[2hnq]], [[1oem]], [[1oeo]], [[1oes]], [[1oet]], [[1oeu]], [[1oev]], [[1sug]], [[2cm2]], [[2cm3]], [[3eu0]], [[3i80]], [[3a5j]], [[6ntp]], [[6xe8]], [[6xee]], [[7key]], [[7l0c]], [[7lfo]], [[7rin]] - hPTP-1b catalytic domain <br /> |
- | **[[ | + | **[[1gfy]], [[1i57]], [[1pa1]], [[2f6f]], [[3a5k]], [[3zv2]], [[3qkp]], [[6olq]], [[6olv]], [[6omy]], [[6pfw]], [[6pg0]], [[6pgt]], [[6pha]], [[6phs]], [[6cwv]], [[6cwu]], [[7fre]], [[7frs]], [[7frt]], [[7fru]], [[7gsc]], [[7gtw]], [[7gtx]], [[7gty]], [[7gtz]], [[7gu0]], [[7gu1]], [[7gu2]], [[7gu3]], [[7gu4]], [[7gu5]], [[7gu6]], [[7gu7]], [[7gu8]], [[7gu9]], [[7gua]], [[7gub]], [[7guc]], [[7ken]], [[7mkz]], [[7mn9]], [[7mnc]], [[7mou]], [[7mov]], [[7s4f]], [[8du7]], [[8exi]], [[8xoy]] - hPTP-1b catalytic domain (mutant) |
- | + | **[[3lnx]] - hPTP-1e PDZ2 domain 1361-1456<br /> | |
- | **[[3pdz]] - hPTP- | + | **[[3pdz]], [[7qcx]] - hPTP-1e PDZ2 domain – NMR<br /> |
+ | **[[2m0z]] - hPTP-1e PDZ2 domain (mutant) – NMR<br /> | ||
+ | **[[5k9v]] – hPTPN1 catalytic domain<br /> | ||
+ | **[[4qah]], [[4qap]], [[4qbe]], [[4qbw]], [[5kaa]], [[5ka8]], [[5ka4]], [[5ka2]], [[5ka1]], [[5ka0]] – hPTPN1 catalytic domain (mutant)<br /> | ||
+ | **[[6zz4]], [[7f5n]], [[7f5o]] – hPTPN2 catalytic domain <br /> | ||
**[[2b49]] – hPTPN3 catalytic domain<br /> | **[[2b49]] – hPTPN3 catalytic domain<br /> | ||
**[[4qun]] – hPTPN3 catalytic domain (mutant) <br /> | **[[4qun]] – hPTPN3 catalytic domain (mutant) <br /> | ||
- | **[[2i75]] – hPTPN4<br /> | + | **[[2i75]] – hPTPN4 611-926<br /> |
- | **[[2cs5]] – hPTPN4 PDZ domain – NMR< | + | **[[2cs5]] – hPTPN4 PDZ domain 507-612 – NMR<br /> |
**[[2vph]] - hPTPN4 PDZ domain<br /> | **[[2vph]] - hPTPN4 PDZ domain<br /> | ||
- | **[[2bij]] – hPTPN5 catalytic domain<br /> | + | **[[2bij]], [[8sls]], [[8slt]], [[8slu]] – hPTPN5 catalytic domain 258-561<br /> |
**[[2bv5]] - hPTPN5 catalytic domain (mutant) <br /> | **[[2bv5]] - hPTPN5 catalytic domain (mutant) <br /> | ||
- | **[[ | + | **[[1zco]], [[2a3k]] – hPTPN7 65-358<br /> |
- | + | **[[2gp0]], [[2hvl]], [[2qdc]], [[2qdm]], [[2qdp]], [[3o4s]], [[3o4t]], [[3o4u]] – hPTPN7 65-360 (mutant) <br /> | |
- | + | **[[2pa5]] – hPTPN9 catalytic domain 277-582<br /> | |
- | + | **[[5hde]] - hPTPN12 catalytic domain 1-301<br /> | |
- | + | **[[5glj]] - hPTPN13 PDZ1 domain 1086-1178<br /> | |
- | + | **[[1wch]] - hPTPN13 2163-2477<br /> | |
- | **[[2gp0]], [[2hvl]], [[2qdc]], [[2qdm]], [[2qdp | + | **[[2bzl]] – hPTPN14 catalytic domain 886-1187<br /> |
- | **[[2pa5]] – hPTPN9 catalytic domain<br /> | + | **[[2oc3]] – hPTPN18 catalytic domain 6-299<br /> |
- | **[[ | + | **[[8gvl]] – hPTPN21 FERM domain 18-318<br /> |
- | **[[ | + | **[[8gvv]] – hPTPN21 PTP domain 876-1174 (mutant)<br /> |
- | **[[ | + | **[[8gxe]] – hPTPN21 FERM+PTP domains <br /> |
- | **[[ | + | **[[2p6x]], [[2qcj]], [[3h2x]] – hPTPN22 catalytic domain 1-302<br /> |
- | **[[ | + | |
- | + | ||
- | **[[ | + | |
- | **[[ | + | |
- | + | ||
- | **[[ | + | |
- | + | ||
- | **[[2p6x]], [[2qcj]], [[3h2x]] – hPTPN22 catalytic domain<br /> | + | |
**[[5cru]], [[5mjz]], [[3rau]] – hRPTP23 domain Bro residues 1-361<br /> | **[[5cru]], [[5mjz]], [[3rau]] – hRPTP23 domain Bro residues 1-361<br /> | ||
**[[5lm2]] – hRPTP23 residues 362-713<br /> | **[[5lm2]] – hRPTP23 residues 362-713<br /> | ||
- | **[[ | + | **[[1rxd]], [[1xm2]] – hPTP PRL-1<br /> |
- | **[[1r6h]], [[1v3a]], [[2mbc]] – hPTP PRL-3 – NMR | + | **[[1r6h]], [[1v3a]], [[2mbc]] – hPTP PRL-3 – NMR<br /> |
- | + | **[[1bvh]] - bPTP – bovine – NMR <br /> | |
- | **[[ | + | |
- | + | ||
- | + | ||
- | + | ||
**[[1c0e]] – bPTP (mutant) – bovine<br /> | **[[1c0e]] – bPTP (mutant) – bovine<br /> | ||
- | **[[1gm1]] - mPTP-BL PDZ2 domain – mouse – NMR< | + | **[[1zck]], [[1x24]] – rPTP 4A1 – rat<br /> |
- | **[[1ozi]] - mPTP-BL PDZ2 domain (mutant) – NMR< | + | **[[3i36]] – rPTP- catalytic domain<br /> |
+ | **[[1gm1]] - mPTP-BL PDZ2 domain – mouse – NMR<br /> | ||
+ | **[[1ozi]] - mPTP-BL PDZ2 domain (mutant) – NMR<br /> | ||
**[[3rgo]] – mPTP-1<br /> | **[[3rgo]] – mPTP-1<br /> | ||
+ | **[[3rgq]] – mPTP-1 + Pi(5)P<br /> | ||
**[[2yz1]] – mPTP SHPS-1 catalytic domain<br /> | **[[2yz1]] – mPTP SHPS-1 catalytic domain<br /> | ||
- | **[[ | + | **[[6x39]] – mPTP F FN#5 domain <br /> |
- | **[[ | + | **[[6gbd]] – mPTP-13 SH3 domain - NMR<br /> |
- | **[[2pi7]] – cPTP CRYP-2 catalytic domain | + | **[[2pi7]] – cPTP CRYP-2 catalytic domain – chicken<br /> |
- | **[[ | + | **[[7mod]], [[7moi]], [[7moj]], [[7mok]], [[7mol]], [[7mom]] – AtPTP DSP1 49-215 – ''Arabidopsis thaliana'' <br /> |
+ | **[[6krw]], [[6krx]] – AtPTP1 1-340 <br /> | ||
+ | **[[1d1p]], [[2j16]] – yPTP – yeast<br /> | ||
**[[2j17]] - yPTP (mutant)<br /> | **[[2j17]] - yPTP (mutant)<br /> | ||
**[[5xw4]] – yPTPN CDC14 <br /> | **[[5xw4]] – yPTPN CDC14 <br /> | ||
+ | **[[6e3b]] – yPTPN SIW14 catalytic domain <br /> | ||
**[[1g4w]] – StPTP – ''Salmonella typhimurium''<br /> | **[[1g4w]] – StPTP – ''Salmonella typhimurium''<br /> | ||
**[[2i6i]], [[3ro1]] – SsPTP – ''Sulfolobus solfataricus''<br /> | **[[2i6i]], [[3ro1]] – SsPTP – ''Sulfolobus solfataricus''<br /> | ||
Line 65: | Line 63: | ||
**[[3js5]], [[3jvi]] – EhPTP – ''Entamoeba histolytica''<br /> | **[[3js5]], [[3jvi]] – EhPTP – ''Entamoeba histolytica''<br /> | ||
**[[2wjd]], [[2wje]], [[2wjf]] – PTP – ''Streptococcus pneumonia''<br /> | **[[2wjd]], [[2wje]], [[2wjf]] – PTP – ''Streptococcus pneumonia''<br /> | ||
- | **[[ | + | **[[3qy6]], [[3qy7]], [[3qy8]] – BsPTP – ''Bacillus subtilis'' <br /> |
- | **[[ | + | **[[4d74]] – PTP AMSI 1-144 (mutant) – ''Erwinia amylovora'' <br /> |
- | **[[ | + | **[[8dhi]], [[8dhj]] – PTP 1-246 (mutant) – ''Clostridioides difficile'' <br /> |
*Non-receptor type PTP complex with peptide | *Non-receptor type PTP complex with peptide | ||
+ | **[[1ptt]], [[1ptu]], [[1g1f]], [[1g1g]], [[1g1h]], [[1een]], [[1eeo]], [[8exj]], [[8exk]], [[8exm]], [[8exn]], [[8eya]], [[8eyb]], [[8eyc]], [[8f88]] - hPTP-1b catalytic domain (mutant) + peptide<br /> | ||
+ | **[[3i7z]] - hPTP-b catalytic domain + peptide<br /> | ||
+ | **[[7qcy]] - hPTP-1e PDZ2 domain + peptide – NMR<br /> | ||
**[[3zmp]], [[3zmq]], [[4zrt]] – hPTPN1 catalytic domain + peptide<br /> | **[[3zmp]], [[3zmq]], [[4zrt]] – hPTPN1 catalytic domain + peptide<br /> | ||
- | **[[3i7z]] - hPTP1B catalytic domain + peptide<br /> | ||
- | **[[1ptt]], [[1ptu]], [[1g1f]], [[1g1g]], [[1g1h]], [[1een]], [[1eeo ]] - hPTP1B catalytic domain (mutant) + peptide<br /> | ||
- | **[[1bzh]] - hPTP1B catalytic domain + fluoromalonyl tyrosine peptide<br /> | ||
- | **[[1bzj]] - hPTP1B catalytic domain + phosphotyrosine mimetic<br /> | ||
- | **[[6hks]] – hPTPN3 489-597 + peptide<br /> | ||
**[[4qum]], [[4rh5]], [[4rh9]], [[4rhg]], [[4s0g]] – hPTPN3 catalytic domain (mutant) 628-909 + peptide<br /> | **[[4qum]], [[4rh5]], [[4rh9]], [[4rhg]], [[4s0g]] – hPTPN3 catalytic domain (mutant) 628-909 + peptide<br /> | ||
+ | **[[6hks]], [[6t36]], [[8cqy]], [[8oep]] – hPTPN3 PDZ domain 489-597 + peptide<br /> | ||
**[[3nfk]], [[3nfl]], [[5eyz]], [[5ez0]] - hPTPN4 PDZ domain + peptide<br /> | **[[3nfk]], [[3nfl]], [[5eyz]], [[5ez0]] - hPTPN4 PDZ domain + peptide<br /> | ||
- | **[[ | + | **[[7vze]] - hPTPN4 PDZ domain + papillomavirus peptide<br /> |
- | + | ||
**[[3d42]], [[3d44]] – hPTPN7 catalytic domain (mutant) + peptide<br /> | **[[3d42]], [[3d44]] – hPTPN7 catalytic domain (mutant) + peptide<br /> | ||
- | **[[4icz | + | **[[4icz]], [[6kzq]], [[6l03]] – hPTPN9 catalytic domain + peptide<br /> |
- | + | ||
**[[5o2p]] – hPTPN12 SH3 domain/peptide<br /> | **[[5o2p]] – hPTPN12 SH3 domain/peptide<br /> | ||
- | **[[3lny]] - hPTPN13 PDZ2 domain + peptide<br /> | + | **[[3lny]], [[7xty]] - hPTPN13 PDZ2 domain 1362-1456 + peptide<br /> |
**[[4gfu]], [[4gfv]] - hPTPN18 residues 6-300 + peptide<br /> | **[[4gfu]], [[4gfv]] - hPTPN18 residues 6-300 + peptide<br /> | ||
**[[4nnd]] - hPTPN18 residues 6-300 (mutant) + ERBB-2<br /> | **[[4nnd]] - hPTPN18 residues 6-300 (mutant) + ERBB-2<br /> | ||
**[[3brh]], [[3olr]] - hPTPN22 catalytic domain + peptide<br /> | **[[3brh]], [[3olr]] - hPTPN22 catalytic domain + peptide<br /> | ||
**[[3omh]] - hPTPN22 catalytic domain (mutant) + peptide<br /> | **[[3omh]] - hPTPN22 catalytic domain (mutant) + peptide<br /> | ||
- | **[[5crv]], [[5mk3]], [[5mk2]], [[5mk1]], [[5mk0]], [[5mjy]] | + | **[[5crv]], [[5mk3]], [[5mk2]], [[5mk1]], [[5mk0]], [[5mjy]] – hRPTP23 domain Bro + peptide<br /> |
**[[5lm1]] – hRPTP23 residues 362-713 + UBAP-1 peptide<br /> | **[[5lm1]] – hRPTP23 residues 362-713 + UBAP-1 peptide<br /> | ||
- | **[[1fpr]] - hPTP SHP-1 catalytic domain + peptide<br /> | ||
- | **[[6roy]] - hPTP SHP-2 N- terminal SH2 domain 1-104 + ITIM peptide <br /> | ||
- | **[[6roz]] - hPTP SHP-2 N- terminal SH2 domain 1-104 + ITSM peptide <br /> | ||
- | **[[6r5g]] - hPTP SHP-2 SH2 domain 105-220 + ITSM peptide – NMR<br /> | ||
**[[3rz2]] - rPTP 4A1 + peptide<br /> | **[[3rz2]] - rPTP 4A1 + peptide<br /> | ||
- | **[[1aya]], [[1ayb]], [[1ayc]], [[1ayd]] – mPTP Syp N terminal SH2 domain + peptide<br /> | + | **[[1aya]], [[1ayb]], [[1ayc]], [[1ayd]] – mPTP Syp N terminal SH2 domain + peptide <br /> |
**[[1vj6]] – mPTP-BL PDZ2 domain + APC C terminal – NMR<br /> | **[[1vj6]] – mPTP-BL PDZ2 domain + APC C terminal – NMR<br /> | ||
**[[6gbe]] – mPTPN13 PDZ3 domain + PRK2 peptide – NMR<br /> | **[[6gbe]] – mPTPN13 PDZ3 domain + PRK2 peptide – NMR<br /> | ||
Line 103: | Line 94: | ||
**[[6g86]] – yPTPN CDC14 + SIC1 peptide<br /> | **[[6g86]] – yPTPN CDC14 + SIC1 peptide<br /> | ||
**[[6g85]], [[6g84]] – yPTPN CDC14 + CBK1 peptide<br /> | **[[6g85]], [[6g84]] – yPTPN CDC14 + CBK1 peptide<br /> | ||
- | **[[2dxp]], [[2i6o]] – SsPTP (mutant) + peptide<br /> | + | **[[2dxp]], [[2i6o]] – SsPTP (mutant) + peptide <br /> |
*Non-receptor type PTP complex with small molecule | *Non-receptor type PTP complex with small molecule | ||
- | **[[1ptv]], [[1pty]] - | + | **[[1ptv]], [[1pty]] - hPTP-1b catalytic domain (mutant) + phosphotyrosine<br /> |
- | **[[1aax]] - | + | **[[1aax]] - hPTP-1b catalytic domain (mutant) + bis-phosphophenyl methane<br /> |
- | **[[1ecv]], [[1c83]], [[1c84]], [[1c85]], [[1c86]], [[1c87]], [[1c88]], [[1g7f]], [[1g7g]], [[1jf7]], [[1l8g]], [[1kak]], [[1kav]], [[1lqf]], [[1nl9]], [[1nny]], [[1no6]], [[1nz7]], [[1ony]], [[1onz]], [[1ph0]], [[1pxh]], [[1pyn]], [[1q1m]], [[1q6j]], [[1q6m]], [[1q6n]], [[1q6p]], [[1q6s]], [[1q6t]], [[1qxk]], [[1t48]], [[1t49]], [[1t4j]], [[1xbo]], [[1wax]], [[2bgd]], [[2bge]], [[2azr]], [[2b07]], [[2f6t]], [[2f6v]], [[2f6w]], [[2f6y]], [[2f6z]], [[2f70]], [[2f71]], [[2fjn]], [[2cm7]], [[2cm8]], [[2cma]], [[2cmb]], [[2cmc]], [[2h4g]], [[2h4k]], [[2hb1]], [[2cne]], [[2cnf]], [[2cng]] | + | **[[1ecv]], [[1c83]], [[1c84]], [[1c85]], [[1c86]], [[1c87]], [[1c88]], [[1g7f]], [[1g7g]], [[1jf7]], [[1l8g]], [[1kak]], [[1kav]], [[1lqf]], [[1nl9]], [[1nny]], [[1no6]], [[1nz7]], [[1ony]], [[1onz]], [[1ph0]], [[1pxh]], [[1pyn]], [[1q1m]], [[1q6j]], [[1q6m]], [[1q6n]], [[1q6p]], [[1q6s]], [[1q6t]], [[1qxk]], [[1t48]], [[1t49]], [[1t4j]], [[1xbo]], [[1wax]], [[2bgd]], [[2bge]], [[2azr]], [[2b07]], [[2f6t]], [[2f6v]], [[2f6w]], [[2f6y]], [[2f6z]], [[2f70]], [[2f71]], [[2fjn]], [[2cm7]], [[2cm8]], [[2cma]], [[2cmb]], [[2cmc]], [[2h4g]], [[2h4k]], [[2hb1]], [[2cne]], [[2cnf]], [[2cng]] [[2cnh]], [[2cni]], [[2nt7]], [[2nta]], [[2veu]], [[2vev]], [[2vew]], [[2vex]], [[2vey]], [[2qbp]], [[2qbq]], [[2qbr]], [[2qbs]], [[3cwe]], [[3d9c]], [[2zmm]], [[2zn7]], [[3eax]], [[3eb1]], [[3sme]], [[4i8n]], [[4y14]], [[5t19]], [[5k9w]], [[6w30]], [[7gs7]], [[7gsa]], [[7gsb]], [[7gsl]], [[7gsm]], [[7gso]], [[7gsr]], [[7gst]], [[7gsv]], [[7gsw]], [[7gsy]], [[7gt0]], [[7gt1]], [[7gt3]], [[7gt4]], [[7gt5]], [[7gt6]], [[7gt7]], [[7gt9]], [[7gta]], [[7gtd]], [[7gte]], [[7gtg]], [[7gth]], [[7gti]], [[7gtk]], [[7gtl]], [[7gtm]], [[7gtn]], [[7gto]], [[7gtt]], [[7gtu]], [[7klx]], [[7mm1]], [[8g6a]], [[8g65]], [[8g67]], [[8g68]], [[8g69]], [[8skl]] - hPTP-1b catalytic domain 1-298 + inhibitor<br /> |
- | **[[ | + | **[[1nwl]], [[1nwe]], [[2fjm]], [[5ka3]], [[5ka7]], [[5ka9]], [[5kab]], [[5kac]], [[5kad]], [[5qde]], [[5qdf]], [[5qdg]], [[5qdh]], [[5qdi]], [[5qdj]], [[5qdk]], [[5qdl]], [[5qdm]], [[5qdn]], [[5qdo]], [[5qdp]], [[5qdq]], [[5qdr]], [[5qds]], [[5qdt]], [[5qdu]], [[5qdv]], [[5qdw]], [[5qdx]], [[5qdy]], [[5qdz]], [[5qe0]], [[5qe1]], [[5qe2]], [[5qe3]], [[5qe4]], [[5qe5]], [[5qe6]], [[5qe7]], [[5qe8]], [[5qe9]], [[5qea]], [[5qeb]], [[5qec]], [[5qed]], [[5qee]], [[5qef]], [[5qeg]], [[5qeh]], [[5qei]], [[5qej]], [[5qek]], [[5qel]], [[5qem]], [[5qen]], [[5qeo]], [[5qep]], [[5qeq]], [[5qer]], [[5qes]], [[5qet]], [[5qeu]], [[5qev]], [[5qew]], [[5qex]], [[5qey]], [[5qez]], [[5qf0]], [[5qf1]], [[5qf2]], [[5qf3]], [[5qf4]], [[5qf5]], [[5qf6]], [[5qf7]], [[5qf8]], [[5qf9]], [[5qfa]], [[5qfb]], [[5qfc]], [[5qfd]], [[5qfe]], [[5qff]], [[5qfg]], [[5qfh]], [[5qfi]], [[5qfj]], [[5qfk]], [[5qfl]], [[5qfm]], [[5qfn]], [[5qfo]], [[5qfp]], [[5qfq]], [[5qfr]], [[5qfs]], [[5qft]], [[5qfu]], [[5qfv]], [[5qfw]], [[5qfx]], [[5qfy]], [[5qfz]], [[5qg0]], [[5qg1]], [[5qg2]], [[5qg3]], [[5qg4]], [[5qg5]], [[5qg6]], [[5qg7]], [[5qg8]], [[5qg9]], [[5qga]], [[5qgb]], [[5qgc]], [[5qgd]], [[5qge]], [[5qgf]], [[7fqm]], [[7fqn]], [[7fqo]], [[7fqp]], [[7fqq]], [[7fqr]], [[7fqs]], [[7fqu]], [[7fqv]], [[7fqw]], [[7fqx]], [[7fqy]], [[7fqz]], [[7frg]], [[7frh]], [[7fri]], [[7frj]], [[7frk]], [[7frl]], [[7frm]], [[7frn]], [[7fro]], [[7frp]], [[7frq]], [[7frr]], [[7gs9]], [[7gsd]], [[7gse]], [[7gsf]], [[7gsg]], [[7gsh]], [[7gsi]], [[7gsj]], [[7gsk]], [[7gsn]], [[7gsq]], [[7gsu]], [[7gsx]], [[7gsz]], [[7gt8]], [[7gtb]], [[7gtc]], [[7gtf]], [[7gtj]], [[7gtp]], [[7gtq]], [[7gtr]], [[7gts]], [[7gtv]], [[7mn7]], [[7mna]], [[7mnb]], [[7mnd]], [[7mne]], [[7mnf]], [[7mow]] - hPTP-1b catalytic domain (mutant) + inhibitor<br /> |
**[[4bjo]] – hPTP1 catalytic domain + NO3<br /> | **[[4bjo]] – hPTP1 catalytic domain + NO3<br /> | ||
- | **[[6pm8]] – hPTPN1b (mutant) + VO4<br /> | + | **[[6xed]], [[6xeg]] – hPTPN1b + WO4<br /> |
+ | **[[6xea]] – hPTPN1b + VO4<br /> | ||
+ | **[[6pm8]], [[6xef]], [[7l0h]] – hPTPN1b (mutant) + VO4<br /> | ||
+ | **[[7uad]] – hPTPN2 1-314 + inhibitor<br /> | ||
**[[4ri4]], [[4ri5]] – hPTPN3 catalytic domain (mutant) + VO4<br /> | **[[4ri4]], [[4ri5]] – hPTPN3 catalytic domain (mutant) + VO4<br /> | ||
- | + | **[[2cjz]] - hPTPN5 catalytic domain 258-563 (mutant) + phosphotyrosine<br /> | |
- | **[[2cjz]] - hPTPN5 catalytic domain (mutant) | + | |
**[[5ow1]], [[5ovx]], [[5ovr]] – hPTP5 catalytic domain + inhibitor<br /> | **[[5ow1]], [[5ovx]], [[5ovr]] – hPTP5 catalytic domain + inhibitor<br /> | ||
**[[4ge2]], [[4ge5]], [[4ge6]] – hPTP9 catalytic domain + inhibitor<br /> | **[[4ge2]], [[4ge5]], [[4ge6]] – hPTP9 catalytic domain + inhibitor<br /> | ||
- | **[[3o5x]], [[4pvg]], [[5ehp]], [[5ehr]], [[4rdd]], [[7jvm]], [[7jvn]] – hPTPN11 catalytic domain + inhibitor<br /> | ||
- | **[[3mow]] - hPTPN11 catalytic domain + tautomycetin analog<br /> | ||
**[[2m10]] - hPTPN13 PDZ2 domain (mutant) + azobenzene derivative – NMR<br /> | **[[2m10]] - hPTPN13 PDZ2 domain (mutant) + azobenzene derivative – NMR<br /> | ||
**[[2qct]], [[4j51]] – hPTPN22 catalytic domain + inhibitor<br /> | **[[2qct]], [[4j51]] – hPTPN22 catalytic domain + inhibitor<br /> | ||
- | **[[5h08]] – hPTP ζ D1 domain + inhibitor<br /> | ||
**[[5bx1]] – hPTP PRL-1 + inhibitor<br /> | **[[5bx1]] – hPTP PRL-1 + inhibitor<br /> | ||
- | + | **[[1dg9]] – bPTP + HEPES<br /> | |
- | + | ||
- | **[[1dg9]] – bPTP + HEPES<br /> | + | |
**[[1zcl]] - rPTP 4A1 (mutant) + sulfate<br /> | **[[1zcl]] - rPTP 4A1 (mutant) + sulfate<br /> | ||
+ | **[[7moe]], [[7mof]], [[7mog]], [[7moh]] – AtPTP DSP1 + inhibitor<br /> | ||
**[[1d2a]] – yPTP + adenine <br /> | **[[1d2a]] – yPTP + adenine <br /> | ||
- | **[[1d1q]] – yPTP (mutant) + PNPP<br /> | + | **[[1d1q]] – yPTP (mutant) + PNPP<br /> |
**[[2i6p]] - SsPTP (mutant) + PNPP<br /> | **[[2i6p]] - SsPTP (mutant) + PNPP<br /> | ||
**[[2i6j]] – SsPTP + phosphate<br /> | **[[2i6j]] – SsPTP + phosphate<br /> | ||
- | **[[2i6m]] – SsPTP + WO4< | + | **[[2i6m]] – SsPTP + WO4<br /> |
**[[3ido]] – EhPTP + HEPES<br /> | **[[3ido]] – EhPTP + HEPES<br /> | ||
- | **[[ | + | **[[7mpd]] – SsoPTP + inhibitor – ''Ssccharolobus solfataricus''<br /> |
- | **[[ | + | **[[7mpc]] – SsoPTP + VO4<br /> |
+ | **[[7ezn]] – PTP + VO4 – ''Cryptococcus neoformans''<br /> | ||
*Non-receptor type PTP complex with protein | *Non-receptor type PTP complex with protein | ||
- | **[[2b4s]] - | + | **[[2b4s]] - hPTP-b catalytic domain + insulin receptor<br /> |
**[[2gph]] - hPTPN7 catalytic domain (mutant) + MAPK2<br /> | **[[2gph]] - hPTPN7 catalytic domain (mutant) + MAPK2<br /> | ||
- | **[[4je4]], [[4jeg]] – hPTPN11 catalytic domain + monobody<br /> | ||
- | **[[6roz]], [[6roy]] – hPTPN11 N-SH2 domain + ITSM<br /> | ||
- | **[[6r5g]] – hPTPN11 C-SH2 domain + ITSM<br /> | ||
**[[6iwd]] – hPTPN14 886-1187 + HPV18 CR3 domain<br /> | **[[6iwd]] – hPTPN14 886-1187 + HPV18 CR3 domain<br /> | ||
**[[5k25]], [[5k24]], [[5k23]] – hPTP PRL-2 + CNNM3<br /> | **[[5k25]], [[5k24]], [[5k23]] – hPTP PRL-2 + CNNM3<br /> | ||
- | **[[5k22 | + | **[[5k22]] – hPTP PRL-2 (mutant) + CNNM3<br /> |
**[[5tsr]] – hPTP PRL-3 (mutant) + CNNM3<br /> | **[[5tsr]] – hPTP PRL-3 (mutant) + CNNM3<br /> | ||
**[[6nmv]], [[6nmu]], [[6nmt]], [[6nms]], [[6nmr]], [[6bit]] - hPTP SHPS-1 + antibody<br /> | **[[6nmv]], [[6nmu]], [[6nmt]], [[6nms]], [[6nmr]], [[6bit]] - hPTP SHPS-1 + antibody<br /> | ||
- | **[[5lxq]] – mPTP + CNNM2<br /> | + | **[[5lxq]] – mPTP PRL-1 + CNNM2<br /> |
+ | **[[6wus]] – mPTP PRL-1 (mutant) + CNNM2<br /> | ||
**[[5mmz]] – mPTP 4A1 + CNNM2<br /> | **[[5mmz]] – mPTP 4A1 + CNNM2<br /> | ||
+ | **[[4pbv]], [[4pbw]] – cPTP CRYP-alpha1 29-316 + TrkC<br /> | ||
**[[4zj7]] – yPTPN CDC14 C terminal + importin<br /> | **[[4zj7]] – yPTPN CDC14 C terminal + importin<br /> | ||
**[[1g4u]] – StPTP + RAS-related C3 botulinum toxin substrate <br /> | **[[1g4u]] – StPTP + RAS-related C3 botulinum toxin substrate <br /> | ||
**[[1jyo]] – StPTP + secretion chaperone SICP<br /> | **[[1jyo]] – StPTP + secretion chaperone SICP<br /> | ||
- | * | + | *Non-receptor type PTP SHP-1 or tyrosine-protein phosphatase non-receptor type 6 |
- | **[[1yts]], [[4yaa]], [[4z6b]], [[4zi4]], [[4zn5]] - YePTP catalytic domain (mutant) – ''Yersinia enterocolitica''<br /> | + | **[[3ps5]] – hPTP SHP-1 (mutant)<br /> |
+ | **[[1gwz]], [[2b3o]], [[4hjp]] – hPTP SHP-1 catalytic domain 242-528<br /> | ||
+ | **[[4gry]], [[4grz]], [[4hjq]] – hPTP SHP-1 catalytic domain (mutant)<br /> | ||
+ | **[[1x6c]] - hPTP SHP-1 C-terminal SH2 domain 105-220 – NMR<br /> | ||
+ | **[[2dju]], [[2edy]] – hPTP SHP-1 FN #3 domain 309-401 NMR<br /> | ||
+ | **[[2dn7]] – hPTP SHP-1 FN3 #6 domain 811-904 - NMR<br /> | ||
+ | **[[1fpr]], [[4gs0]] - hPTP SHP-1 catalytic domain + peptide<br /> | ||
+ | **[[2rmx]], [[2yu7]] – hPTP SHP-1 C-terminal SH2 domain + peptide – NMR<br /> | ||
+ | **[[6sm5]] - hPTP SHP-1 C-terminal SH2 domain + monobody<br /> | ||
+ | |||
+ | *Non-receptor type PTP SHP-2 or tyrosine-protein phosphatase non-receptor type 11 | ||
+ | |||
+ | **[[4dgp]] – hPTP SHP-2 SH2+catalytic domains 1-532<br /> | ||
+ | **[[2shp]], [[4dgx]], [[4gwf]], [[4h1o]], [[4h34]], [[4nwf]], [[4nwg]], [[4ohd]], [[4ohe]], [[4ohh]], [[4ohi]], [[4ohl]], [[5bk8]], [[6crf]], [[6cmp]] – hPTP SHP-2 SH2+catalytic domains (mutant)<br /> | ||
+ | **[[6cmq]] - hPTP SHP-2 106-529<br /> | ||
+ | **[[3b7o]], [[3zm0]], [[3zm1]], [[3zm2]], [[3zm3]] – hPTP SHP-2 catalytic domain 248-527<br /> | ||
+ | **[[5j8r]], [[5i6v]], [[5ibm]], [[5ibs]], [[7emn]] – hPTP SHP-2 catalytic domain (mutant)<br /> | ||
+ | **[[3tl0]], [[3tkz]], [[4qsy]], [[5df6]], [[5x7b]], [[5x94]] – hPTPN11 SH2 domain 1-220 + peptide<br /> | ||
+ | **[[6roy]] - hPTP SHP-2 N- terminal SH2 domain 1-104 + ITIM peptide <br /> | ||
+ | **[[6roz]] - hPTP SHP-2 N- terminal SH2 domain + ITSM peptide <br /> | ||
+ | **[[6r5g]] - hPTP SHP-2 SH2 domain 105-220 + ITSM peptide – NMR<br /> | ||
+ | **[[7ppl]], [[7ppm]], [[7ppn]] - hPTP SHP-2 catalytic domain (mutant) + peptide<br /> | ||
+ | **[[3mow]] - hPTP SHP-2 catalytic domain + inhibitor<br /> | ||
+ | **[[3o5x]], [[4pvg]], [[4rdd]], [[5ehp]], [[5ehr]], [[5xzr]], [[6md7]], [[6md9]], [[6mda]], [[6mdb]], [[6mdc]], [[6mdd]], [[6wu8]], [[7jvm]], [[7jvn]], [[7r75]], [[7r7d]], [[7r7i]], [[7r7l]], [[7rct]], [[7vxg]], [[8b5y]], [[8cbh]], [[8t6d]], [[8u7w]], [[8u7x]] - hPTP SHP-2 SH2+catalytic domains + inhibitor<br /> | ||
+ | **[[6cmr]], [[6cms]], [[6crg]] - hPTP SHP-2 SH2+catalytic domains (mutant) + inhibitor<br /> | ||
+ | **[[8t7q]] - hPTP SHP-2 SH2+catalytic domains + drug<br /> | ||
+ | **[[4je4]], [[4jeg]] – hPTP SHP-2 N-terminal SH2 domain + monobody<br /> | ||
+ | **[[7tvj]] – hPTP SHP-2 catalytic domain 224-525 + monobody<br /> | ||
+ | |||
+ | *Yersinia PTP Yop | ||
+ | |||
+ | **[[1yts]], [[4yaa]], [[4z6b]], [[4zi4]], [[4zn5]], [[6xft]] - YePTP catalytic domain (mutant) – ''Yersinia enterocolitica''<br /> | ||
+ | **[[7l0i]] – YePTP (mutant) <br /> | ||
**[[1xxp]], [[1xxv]] - YePTP catalytic domain (mutant) + peptide<br /> | **[[1xxp]], [[1xxv]] - YePTP catalytic domain (mutant) + peptide<br /> | ||
- | **[[2i42]] – YePTP (mutant) + VO4<br /> | + | **[[2i42]], [[7l0m]] – YePTP (mutant) + VO4<br /> |
**[[1ypt]], [[1ytw]] – YePTP catalytic domain + WO4<br /> | **[[1ypt]], [[1ytw]] – YePTP catalytic domain + WO4<br /> | ||
**[[1ytn]] - YePTP catalytic domain + NO3<br /> | **[[1ytn]] - YePTP catalytic domain + NO3<br /> | ||
Line 165: | Line 186: | ||
**[[1pa9]], [[3bm8]] - YePTP catalytic domain (mutant) + inhibitor<br /> | **[[1pa9]], [[3bm8]] - YePTP catalytic domain (mutant) + inhibitor<br /> | ||
**[[3u96]] - YePTP catalytic domain (mutant) + PNCS<br /> | **[[3u96]] - YePTP catalytic domain (mutant) + PNCS<br /> | ||
- | **[[1huf]] – YpPTP - '' | + | **[[1huf]] – YpPTP - ''Yerisnia pestis''<br /> |
**[[1qz0]] - YpPTP catalytic domain + peptide<br /> | **[[1qz0]] - YpPTP catalytic domain + peptide<br /> | ||
**[[2y2f]] - YpPTP catalytic domain + inhibitor<br /> | **[[2y2f]] - YpPTP catalytic domain + inhibitor<br /> | ||
Line 172: | Line 193: | ||
**[[4gf3]] – YpPTP + Yop targeting protein<br /> | **[[4gf3]] – YpPTP + Yop targeting protein<br /> | ||
- | * | + | *Receptor-type PTP |
**[[1yfo]], [[2i1y]] – mRPTP-α catalytic domain<br /> | **[[1yfo]], [[2i1y]] – mRPTP-α catalytic domain<br /> | ||
Line 183: | Line 204: | ||
**[[2yd1]], [[2yd2]], [[3pxj]] – DmRPTP Ig1-2 domain – ''Drosophila melanogaster''<br /> | **[[2yd1]], [[2yd2]], [[3pxj]] – DmRPTP Ig1-2 domain – ''Drosophila melanogaster''<br /> | ||
**[[3s3e]] – DmRPTP-10D catalytic domain<br /> | **[[3s3e]] – DmRPTP-10D catalytic domain<br /> | ||
+ | **[[6x38]] – DmRPTP FN5 domain<br /> | ||
- | * | + | *Human receptor-type PTP |
**[[6uzt]] - hRPTP-α catalytic domain<br /> | **[[6uzt]] - hRPTP-α catalytic domain<br /> | ||
Line 202: | Line 224: | ||
**[[2dlh]], [[1x5z]] - hRPTP-δ FN3 domain 405-514 – NMR<BR /> | **[[2dlh]], [[1x5z]] - hRPTP-δ FN3 domain 405-514 – NMR<BR /> | ||
**[[2yd6]], [[2yd7]] - hRPTP-δ Ig1-2 domain 21-220<br /> | **[[2yd6]], [[2yd7]] - hRPTP-δ Ig1-2 domain 21-220<br /> | ||
+ | **[[6x3a]] - hRPTP-δ FN4-FN6 domain 607-916<br /> | ||
**[[2jjd]] - hRPTP-ε residues 107-697<br /> | **[[2jjd]] - hRPTP-ε residues 107-697<br /> | ||
**[[6d4d]] - hRPTP-ε domain D1 residues 22-313<br /> | **[[6d4d]] - hRPTP-ε domain D1 residues 22-313<br /> | ||
**[[6d4f]], [[6d3f]] - hRPTP-ε domain D2 residues 425-700<br /> | **[[6d4f]], [[6d3f]] - hRPTP-ε domain D2 residues 425-700<br /> | ||
- | **[[ | + | **[[8a1f]] - hRPTP-kappa N-terminal residues 28-385<br /> |
- | **[[2c7s]] - hRPTP- | + | **[[2c7s]] - hRPTP-kappa residues 865-1154<br /> |
**[[1rpm]] - hRPTP-μ catalytic domain<br /> | **[[1rpm]] - hRPTP-μ catalytic domain<br /> | ||
**[[2c9a]] - hRPTP-μ MAM-IG module<br /> | **[[2c9a]] - hRPTP-μ MAM-IG module<br /> | ||
**[[2v5y]] - hRPTP-μ extracellular region<br /> | **[[2v5y]] - hRPTP-μ extracellular region<br /> | ||
- | **[[ | + | **[[8a16]], [[8a17]] - hRPTP- FN#3-4 domain 478-723<br /> |
- | **[[2cfv]] – hRPTP- | + | **[[2g59]], [[2gjt]] - hRPTP- catalytic domain<br /> |
- | **[[2nz6]] - hRPTP- | + | **[[7u08]] - hRPTP-eta residues 37-374<br /> |
- | **[[2dle]] - hRPTP- | + | **[[7u01]] - hRPTP-eta residues 206-364<br /> |
+ | **[[2cfv]] – hRPTP-eta residues 1019-1311<br /> | ||
+ | **[[2nz6]] - hRPTP-eta residues 1019-1311 (mutant) <br /> | ||
+ | **[[2dle]] - hRPTP-eta FN3 domain – NMR<BR /> | ||
**[[2qep]] – hRPTP-ν2 D1 domain<br /> | **[[2qep]] – hRPTP-ν2 D1 domain<br /> | ||
**[[4hti]], [[4htj]] – hRPTP-ν2 membrane proximal ectodomain<br /> | **[[4hti]], [[4htj]] – hRPTP-ν2 membrane proximal ectodomain<br /> | ||
Line 231: | Line 257: | ||
**[[6j6u]] - rRPTP-ζ D1-D2 domain<br /> | **[[6j6u]] - rRPTP-ζ D1-D2 domain<br /> | ||
**[[3jxg]], [[3jxh]] - mRPTP-γ CA-like domain<br /> | **[[3jxg]], [[3jxh]] - mRPTP-γ CA-like domain<br /> | ||
+ | **[[7xc0]] - hRPTP-H 797-1086<br /> | ||
- | *Receptor type | + | *Receptor-type PTP complexes |
**[[2h02]], [[2h04]], [[2i3u]], [[2i4e]], [[2i4g]], [[2i4h]] - hRPTP-β catalytic domain + inhibitor<br /> | **[[2h02]], [[2h04]], [[2i3u]], [[2i4e]], [[2i4g]], [[2i4h]] - hRPTP-β catalytic domain + inhibitor<br /> | ||
Line 247: | Line 274: | ||
**[[6kip]] - hRPTP-d residues 1617-1912 + liprin<br /> | **[[6kip]] - hRPTP-d residues 1617-1912 + liprin<br /> | ||
**[[2yd8]] - hRPTP-σ Ig1-2 domain + sucrose octasulfate<br /> | **[[2yd8]] - hRPTP-σ Ig1-2 domain + sucrose octasulfate<br /> | ||
- | **[[3s97]] - hRPTP- | + | **[[3s97]] - hRPTP-zeta CA-like domain 34-302 + congtactin Ig domains<br /> |
- | **[[5h08]] – hPTP | + | **[[8fn8]], [[8fn9]] – hPTP zeta FN domain 310-411 + tenascin fg domain<br /> |
+ | **[[5h08]] – hPTP zeta D1 domain 1698-1993 + inhibitor<br /> | ||
**[[6kr4]] - hRPTP-F residues 1332-1907 + liprin<br /> | **[[6kr4]] - hRPTP-F residues 1332-1907 + liprin<br /> | ||
**[[1ygr]] – hRPTP CD45 cytoplasmic domain (mutant) + T-cell receptor peptide<br /> | **[[1ygr]] – hRPTP CD45 cytoplasmic domain (mutant) + T-cell receptor peptide<br /> | ||
Line 259: | Line 287: | ||
**[[3s3k]] - DmRPTP-10D catalytic domain + inhibitor<br /> | **[[3s3k]] - DmRPTP-10D catalytic domain + inhibitor<br /> | ||
- | * | + | *Dual-specificity PTP DUSP see [[MAP kinase phosphatase]] |
- | * | + | *Class II – Low molecular weight PTP (LMW-PTP) |
- | + | **[[1xww]], [[4z99]], [[5jnr]], [[5jns]], [[5jnt]] – hLMW-PTP<br /> | |
- | + | **[[6y2v]], [[6y2w]] – hLMW-PTP (mutant) <br /> | |
- | **[[1xww]], [[4z99]], [[ | + | **[[1phr]] – bLMW-PTP<br /> |
- | **[[1phr]] - bLMW-PTP<br /> | + | **[[5jnv]] – bLMW-PTP (mutant) <br /> |
- | **[[1p8a]] – LMW-PTP (mutant) – ''Tritrichomonas foetus'' – NMR< | + | **[[5jnu]] – mLMW-PTP <br /> |
+ | **[[7cuy]] – DmLMW-PTP <br /> | ||
+ | **[[1p8a]] – LMW-PTP (mutant) – ''Tritrichomonas foetus'' – NMR<br /> | ||
**[[2cwd]] – LMW-PTP – ''Thermus thermophilus''<br /> | **[[2cwd]] – LMW-PTP – ''Thermus thermophilus''<br /> | ||
**[[5got]] – LMW-PTP – ''Streptococcus pyogenes''<br /> | **[[5got]] – LMW-PTP – ''Streptococcus pyogenes''<br /> | ||
- | **[[5z3m]] – LMW-PTP – ''Vibrio cholerae''<br /> | ||
**[[1u2p]], [[2luo]] – MtLMW-PTP – ''Mycobacterium tuberculosis''<br /> | **[[1u2p]], [[2luo]] – MtLMW-PTP – ''Mycobacterium tuberculosis''<br /> | ||
- | **[[ | + | **[[2fek]], [[2wja]] – LMW-PTP Wzb – ''Escherichia coli''<br /> |
- | + | ||
**[[4eti]], [[4etm]], [[4kk3]] – BsLMW-PTP<br /> | **[[4eti]], [[4etm]], [[4kk3]] – BsLMW-PTP<br /> | ||
**[[4etn]], [[4kk4]] – BsLMW-PTP (mutant)<br /> | **[[4etn]], [[4kk4]] – BsLMW-PTP (mutant)<br /> | ||
+ | **[[7dhd]] – VvLMW-PTP Wzb – ''Vibrio vulnificus'' <br /> | ||
+ | **[[4egs]] – LMW-PTP N-terminal 1-146 – ''Thermoanaerobacter tengcongensis'' <br /> | ||
+ | **[[2gi4]] – LMW-PTP – ''Campylobacter jejuni''<br /> | ||
*LMW-PTP complex | *LMW-PTP complex | ||
- | **[[5kqg]], [[5kql]], [[5kqm]], [[5kqp]] – hLMW-PTP + inhibitor<br /> | + | **[[3n8i]], [[5kqg]], [[5kql]], [[5kqm]], [[5kqp]], [[7kh8]], [[7uw6]] – hLMW-PTP + inhibitor<br /> |
**[[4z9a]] – hLMW-PTP + phenylmethanesulfonic acid<br /> | **[[4z9a]] – hLMW-PTP + phenylmethanesulfonic acid<br /> | ||
**[[4z9b]] – hLMW-PTP + benzylphosphonic acid<br /> | **[[4z9b]] – hLMW-PTP + benzylphosphonic acid<br /> | ||
Line 288: | Line 319: | ||
**[[1u2q]] – MtLMW-PTP + glycerol<br /> | **[[1u2q]] – MtLMW-PTP + glycerol<br /> | ||
**[[2oz5]] – MtLMW-PTP + inhibitor<br /> | **[[2oz5]] – MtLMW-PTP + inhibitor<br /> | ||
+ | **[[7dhe]], [[7dhf]] – VvLMW-PTP Wzb + inhibitor<br /> | ||
- | * | + | *For LMW-PTP from Synechocystis see [[Arsenate reductase]] |
- | * | + | *Class III – CDC25 or M-phase inducer phosphatase 2 |
**[[1c25]] – hCDC25A catalytic domain (mutant) <br /> | **[[1c25]] – hCDC25A catalytic domain (mutant) <br /> | ||
Line 302: | Line 334: | ||
**[[3op3]] – hCDC25C residues 270-462 | **[[3op3]] – hCDC25C residues 270-462 | ||
- | * | + | *Class IV |
**[[4tvv]] – PTP – ''Legionella pneumophila''<br /> | **[[4tvv]] – PTP – ''Legionella pneumophila''<br /> | ||
- | * | + | *T-cell tyrosine phosphatase |
**[[1l8k]] – hTC-PTP | **[[1l8k]] – hTC-PTP | ||
- | * | + | *Other tyrosine phosphatases |
**[[4az1]] – PTP – ''Trypanosoma cruzi''<br /> | **[[4az1]] – PTP – ''Trypanosoma cruzi''<br /> |
Current revision
3D Structures of tyrosine phosphatase
Updated on 21-August-2024 - For a general description of the protein see Tyrosine phosphatase