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7dd3
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| - | ==== | + | ==Cryo-EM structure of the pre-mRNA-loaded DEAH-box ATPase/helicase Prp2 in complex with Spp2== |
| - | <StructureSection load='7dd3' size='340' side='right'caption='[[7dd3]]' scene=''> | + | <StructureSection load='7dd3' size='340' side='right'caption='[[7dd3]], [[Resolution|resolution]] 3.20Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[7dd3]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7DD3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7DD3 FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.2Å</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7dd3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7dd3 OCA], [https://pdbe.org/7dd3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7dd3 RCSB], [https://www.ebi.ac.uk/pdbsum/7dd3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7dd3 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PRP2_YEAST PRP2_YEAST] Involved in pre-mRNA splicing. Is required together with ATP and at least one other factor, for the first cleavage-ligation reaction. Functions as a molecular motor in the activation of the precatalytic spliceosome for the first transesterification reaction of pre-mRNA splicing by hydrolyzing ATP to cause the activation of the spliceosome without the occurrence of splicing. Capable of hydrolyzing nucleoside triphosphates in the presence of single-stranded RNAs such as poly(U).<ref>PMID:14730020</ref> <ref>PMID:1534753</ref> <ref>PMID:2251118</ref> <ref>PMID:8112302</ref> <ref>PMID:8943336</ref> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Helicase 3D structures|Helicase 3D structures]] | ||
| + | *[[Pre-mRNA splicing factors 3D structures|Pre-mRNA splicing factors 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Saccharomyces cerevisiae]] |
| + | [[Category: Bai R]] | ||
| + | [[Category: Lei J]] | ||
| + | [[Category: Qi J]] | ||
| + | [[Category: Shi Y]] | ||
| + | [[Category: Wan R]] | ||
| + | [[Category: Yan C]] | ||
| + | [[Category: Zhang P]] | ||
Current revision
Cryo-EM structure of the pre-mRNA-loaded DEAH-box ATPase/helicase Prp2 in complex with Spp2
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Categories: Large Structures | Saccharomyces cerevisiae | Bai R | Lei J | Qi J | Shi Y | Wan R | Yan C | Zhang P
