1wrj

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<StructureSection load='1wrj' size='340' side='right'caption='[[1wrj]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='1wrj' size='340' side='right'caption='[[1wrj]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1wrj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Dsm_16993 Dsm 16993]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WRJ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1WRJ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1wrj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sulfurisphaera_tokodaii Sulfurisphaera tokodaii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WRJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WRJ FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ST0967 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=111955 DSM 16993])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Methylated-DNA--[protein]-cysteine_S-methyltransferase Methylated-DNA--[protein]-cysteine S-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.63 2.1.1.63] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wrj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wrj OCA], [https://pdbe.org/1wrj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wrj RCSB], [https://www.ebi.ac.uk/pdbsum/1wrj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wrj ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1wrj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wrj OCA], [http://pdbe.org/1wrj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1wrj RCSB], [http://www.ebi.ac.uk/pdbsum/1wrj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1wrj ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/OGT_SULTO OGT_SULTO]] Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated (By similarity).
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[https://www.uniprot.org/uniprot/OGT_SULTO OGT_SULTO] Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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<jmolCheckbox>
<jmolCheckbox>
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wr/1wrj_consurf.spt"</scriptWhenChecked>
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wr/1wrj_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Dsm 16993]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Kuroda, M]]
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[[Category: Sulfurisphaera tokodaii]]
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[[Category: Nakamura, K T]]
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[[Category: Kuroda M]]
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[[Category: Tsunoda, M]]
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[[Category: Nakamura KT]]
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[[Category: Methyltransferase]]
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[[Category: Tsunoda M]]
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[[Category: Transferase]]
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Current revision

Crystal structure of O6-methylguanine methyltransferase from Sulfolobus tokodaii

PDB ID 1wrj

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