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1x40
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==Solution structure of the SAM domain of human ARAP2== | ==Solution structure of the SAM domain of human ARAP2== | ||
| - | <StructureSection load='1x40' size='340' side='right'caption='[[1x40 | + | <StructureSection load='1x40' size='340' side='right'caption='[[1x40]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1x40]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[1x40]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X40 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1X40 FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1x40 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x40 OCA], [https://pdbe.org/1x40 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1x40 RCSB], [https://www.ebi.ac.uk/pdbsum/1x40 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1x40 ProSAT], [https://www.topsan.org/Proteins/RSGI/1x40 TOPSAN]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/ARAP2_HUMAN ARAP2_HUMAN] Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency (By similarity). |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Inoue | + | [[Category: Inoue M]] |
| - | [[Category: Kigawa | + | [[Category: Kigawa T]] |
| - | [[Category: Koshiba | + | [[Category: Koshiba S]] |
| - | + | [[Category: Sasagawa A]] | |
| - | [[Category: Sasagawa | + | [[Category: Tochio N]] |
| - | [[Category: Tochio | + | [[Category: Yokoyama S]] |
| - | [[Category: Yokoyama | + | |
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Current revision
Solution structure of the SAM domain of human ARAP2
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Categories: Homo sapiens | Large Structures | Inoue M | Kigawa T | Koshiba S | Sasagawa A | Tochio N | Yokoyama S
