1x5q

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (14:00, 9 May 2024) (edit) (undo)
 
(One intermediate revision not shown.)
Line 1: Line 1:
==Solution structure of the first PDZ domain of scribble homolog protein (hScrib)==
==Solution structure of the first PDZ domain of scribble homolog protein (hScrib)==
-
<StructureSection load='1x5q' size='340' side='right'caption='[[1x5q]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
+
<StructureSection load='1x5q' size='340' side='right'caption='[[1x5q]]' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[1x5q]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X5Q OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1X5Q FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[1x5q]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X5Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1X5Q FirstGlance]. <br>
-
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SCRIB, CRIB1, KIAA0147, LAP4, SCRB1, VARTUL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1x5q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x5q OCA], [http://pdbe.org/1x5q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1x5q RCSB], [http://www.ebi.ac.uk/pdbsum/1x5q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1x5q ProSAT], [http://www.topsan.org/Proteins/RSGI/1x5q TOPSAN]</span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1x5q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x5q OCA], [https://pdbe.org/1x5q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1x5q RCSB], [https://www.ebi.ac.uk/pdbsum/1x5q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1x5q ProSAT], [https://www.topsan.org/Proteins/RSGI/1x5q TOPSAN]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
-
[[http://www.uniprot.org/uniprot/SCRIB_HUMAN SCRIB_HUMAN]] The disease is caused by mutations affecting the gene represented in this entry.
+
[https://www.uniprot.org/uniprot/SCRIB_HUMAN SCRIB_HUMAN] The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/SCRIB_HUMAN SCRIB_HUMAN]] Scaffold protein involved in different aspects of polarized cells differentiation regulating epithelial and neuronal morphogenesis. Most probably functions in the establishment of apico-basal cell polarity. May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium. May also function in cell migration and adhesion and hence regulate cell invasion through MAPK signaling. May play a role in exocytosis and in the targeting synaptic vesicles to synapses. Functions as an activator of Rac GTPase activity.<ref>PMID:15182672</ref> <ref>PMID:15775968</ref> <ref>PMID:16344308</ref> <ref>PMID:16965391</ref> <ref>PMID:18641685</ref> <ref>PMID:18716323</ref> <ref>PMID:19041750</ref>
+
[https://www.uniprot.org/uniprot/SCRIB_HUMAN SCRIB_HUMAN] Scaffold protein involved in different aspects of polarized cells differentiation regulating epithelial and neuronal morphogenesis. Most probably functions in the establishment of apico-basal cell polarity. May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium. May also function in cell migration and adhesion and hence regulate cell invasion through MAPK signaling. May play a role in exocytosis and in the targeting synaptic vesicles to synapses. Functions as an activator of Rac GTPase activity.<ref>PMID:15182672</ref> <ref>PMID:15775968</ref> <ref>PMID:16344308</ref> <ref>PMID:16965391</ref> <ref>PMID:18641685</ref> <ref>PMID:18716323</ref> <ref>PMID:19041750</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Line 25: Line 25:
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Human]]
+
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
-
[[Category: Hayashi, F]]
+
[[Category: Hayashi F]]
-
[[Category: Nagashima, T]]
+
[[Category: Nagashima T]]
-
[[Category: Qin, X R]]
+
[[Category: Qin XR]]
-
[[Category: Structural genomic]]
+
[[Category: Yokoyama S]]
-
[[Category: Yokoyama, S]]
+
-
[[Category: Cell adhesion]]
+
-
[[Category: Cell cycle]]
+
-
[[Category: Hscrib]]
+
-
[[Category: Lap4 protein]]
+
-
[[Category: National project on protein structural and functional analyse]]
+
-
[[Category: Nppsfa]]
+
-
[[Category: Pdz domain]]
+
-
[[Category: Rsgi]]
+
-
[[Category: Scribble homolog protein]]
+

Current revision

Solution structure of the first PDZ domain of scribble homolog protein (hScrib)

PDB ID 1x5q

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1x5q"
Personal tools