1xmu

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (00:39, 21 November 2024) (edit) (undo)
 
(One intermediate revision not shown.)
Line 3: Line 3:
<StructureSection load='1xmu' size='340' side='right'caption='[[1xmu]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
<StructureSection load='1xmu' size='340' side='right'caption='[[1xmu]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[1xmu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XMU OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1XMU FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[1xmu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XMU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XMU FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ROF:3-(CYCLOPROPYLMETHOXY)-N-(3,5-DICHLOROPYRIDIN-4-YL)-4-(DIFLUOROMETHOXY)BENZAMIDE'>ROF</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
-
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene></td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ROF:3-(CYCLOPROPYLMETHOXY)-N-(3,5-DICHLOROPYRIDIN-4-YL)-4-(DIFLUOROMETHOXY)BENZAMIDE'>ROF</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1xlx|1xlx]], [[1xlz|1xlz]], [[1xm4|1xm4]], [[1xm6|1xm6]], [[1xmy|1xmy]], [[1xn0|1xn0]], [[1xom|1xom]], [[1xon|1xon]], [[1xoq|1xoq]], [[1xor|1xor]], [[1xos|1xos]], [[1xot|1xot]], [[1xoz|1xoz]], [[1xp0|1xp0]]</div></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xmu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xmu OCA], [https://pdbe.org/1xmu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xmu RCSB], [https://www.ebi.ac.uk/pdbsum/1xmu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xmu ProSAT]</span></td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PDE4B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+
-
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3',5'-cyclic-nucleotide_phosphodiesterase 3',5'-cyclic-nucleotide phosphodiesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.17 3.1.4.17] </span></td></tr>
+
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1xmu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xmu OCA], [http://pdbe.org/1xmu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1xmu RCSB], [http://www.ebi.ac.uk/pdbsum/1xmu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1xmu ProSAT]</span></td></tr>
+
</table>
</table>
-
== Function ==
 
-
[[http://www.uniprot.org/uniprot/PDE4B_HUMAN PDE4B_HUMAN]] Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents.<ref>PMID:10846163</ref> <ref>PMID:15003452</ref>
 
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Line 18: Line 13:
<jmolCheckbox>
<jmolCheckbox>
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xm/1xmu_consurf.spt"</scriptWhenChecked>
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xm/1xmu_consurf.spt"</scriptWhenChecked>
-
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
Line 39: Line 34:
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: 3',5'-cyclic-nucleotide phosphodiesterase]]
+
[[Category: Homo sapiens]]
-
[[Category: Human]]
+
[[Category: Large Structures]]
[[Category: Large Structures]]
-
[[Category: Artis, D R]]
+
[[Category: Artis DR]]
-
[[Category: Bollag, G]]
+
[[Category: Bollag G]]
-
[[Category: Card, G L]]
+
[[Category: Card GL]]
-
[[Category: England, B P]]
+
[[Category: England BP]]
-
[[Category: Fong, D]]
+
[[Category: Fong D]]
-
[[Category: Gillette, S]]
+
[[Category: Gillette S]]
-
[[Category: Ibrahim, P N]]
+
[[Category: Ibrahim PN]]
-
[[Category: Kim, S H]]
+
[[Category: Kim S-H]]
-
[[Category: Lee, B]]
+
[[Category: Lee B]]
-
[[Category: Luu, C]]
+
[[Category: Luu C]]
-
[[Category: Milburn, M V]]
+
[[Category: Milburn MV]]
-
[[Category: Powell, B]]
+
[[Category: Powell B]]
-
[[Category: Schlessinger, J]]
+
[[Category: Schlessinger J]]
-
[[Category: Suzuki, Y]]
+
[[Category: Suzuki Y]]
-
[[Category: Tabrizizad, M]]
+
[[Category: Tabrizizad M]]
-
[[Category: Zhang, K Y.J]]
+
[[Category: Zhang KYJ]]
-
[[Category: Hydrolase]]
+
-
[[Category: Pde]]
+
-
[[Category: Pde4b]]
+
-
[[Category: Phosphodiesterase]]
+
-
[[Category: Roflumilast]]
+

Current revision

Catalytic Domain Of Human Phosphodiesterase 4B In Complex With Roflumilast

PDB ID 1xmu

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1xmu"
Personal tools