7ldk
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of human respiratory syncytial virus nonstructural protein 2 (NS2)== | |
| + | <StructureSection load='7ldk' size='340' side='right'caption='[[7ldk]], [[Resolution|resolution]] 2.82Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[7ldk]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_respiratory_syncytial_virus_A_strain_Long Human respiratory syncytial virus A strain Long]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7LDK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7LDK FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.82Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=TAR:D(-)-TARTARIC+ACID'>TAR</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ldk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ldk OCA], [https://pdbe.org/7ldk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ldk RCSB], [https://www.ebi.ac.uk/pdbsum/7ldk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ldk ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/NS2_HRSVL NS2_HRSVL] Plays a major role in antagonizing the type I IFN-mediated antiviral response. Acts cooperatively with NS1 to repress activation and nuclear translocation of host IFN-regulatory factor IRF3. Interacts with the host cytoplasmic sensor of viral nucleic acids RIGI and prevents the interaction with its downstream partner MAVS. Together with NS2, participates in the proteasomal degradation of host STAT2, IRF3, IRF7, TBK1 and RIGI through a NS-degradasome involving CUL2 and Elongin-C. The degradasome requires an intact mitochondrial MAVS. Induces host SOCS1 expression. Induces activation of NF-kappa-B. Suppresses premature apoptosis by an NF-kappa-B-dependent, interferon-independent mechanism promoting continued viral replication.[UniProtKB:P04543] | ||
| - | + | ==See Also== | |
| - | + | *[[Nonstructural protein 3D structures|Nonstructural protein 3D structures]] | |
| - | + | __TOC__ | |
| - | [[Category: | + | </StructureSection> |
| + | [[Category: Human respiratory syncytial virus A strain Long]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Amarasinghe GK]] | ||
| + | [[Category: Borek D]] | ||
| + | [[Category: Chatterjee S]] | ||
| + | [[Category: Leung DW]] | ||
| + | [[Category: Otwinowski Z]] | ||
Current revision
Structure of human respiratory syncytial virus nonstructural protein 2 (NS2)
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