1z6u
From Proteopedia
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<StructureSection load='1z6u' size='340' side='right'caption='[[1z6u]], [[Resolution|resolution]] 2.10Å' scene=''> | <StructureSection load='1z6u' size='340' side='right'caption='[[1z6u]], [[Resolution|resolution]] 2.10Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1z6u]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[1z6u]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z6U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Z6U FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1z6u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z6u OCA], [https://pdbe.org/1z6u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1z6u RCSB], [https://www.ebi.ac.uk/pdbsum/1z6u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1z6u ProSAT]</span></td></tr> | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
| - | == Disease == | ||
| - | [[http://www.uniprot.org/uniprot/UHRF2_HUMAN UHRF2_HUMAN]] Associated with various cancers. DNA copy number loss is found in multiple kinds of malignancies originating from the brain, breast, stomach, kidney, hematopoietic tissue and lung. | ||
| - | == Function == | ||
| - | [[http://www.uniprot.org/uniprot/UHRF2_HUMAN UHRF2_HUMAN]] E3 ubiquitin-protein ligase that is an intermolecular hub protein in the cell cycle network. Through cooperative DNA and histone binding, may contribute to a tighter epigenetic control of gene expression in differentiated cells. Ubiquitinates cyclins, CCND1 and CCNE1, in an apparently phosphorylation-independent manner and induces G1 arrest. Also ubiquitinates PCNP leading to its degradation by the proteasome. E3 SUMO-, but not ubiquitin-, protein ligase for ZNF131.<ref>PMID:12176013</ref> <ref>PMID:15178429</ref> <ref>PMID:14741369</ref> <ref>PMID:15361834</ref> <ref>PMID:21952639</ref> <ref>PMID:23404503</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z6/1z6u_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z6/1z6u_consurf.spt"</scriptWhenChecked> | ||
| - | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/ | + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked> |
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1z6u ConSurf]. | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1z6u ConSurf]. | ||
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
| - | == References == | ||
| - | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | + | [[Category: Arrowsmith C]] | |
| - | [[Category: Arrowsmith | + | [[Category: Avvakumov GV]] |
| - | [[Category: Avvakumov | + | [[Category: Bochkarev A]] |
| - | [[Category: Bochkarev | + | [[Category: Dhe-Paganon S]] |
| - | [[Category: Dhe-Paganon | + | [[Category: Edwards A]] |
| - | [[Category: Edwards | + | [[Category: Mackenzie F]] |
| - | [[Category: Mackenzie | + | [[Category: Newman EM]] |
| - | [[Category: Newman | + | [[Category: Sundstrom M]] |
| - | + | [[Category: Walker JR]] | |
| - | [[Category: Sundstrom | + | [[Category: Xue S]] |
| - | [[Category: Walker | + | |
| - | [[Category: Xue | + | |
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Current revision
Np95-like ring finger protein isoform b [Homo sapiens]
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Categories: Homo sapiens | Large Structures | Arrowsmith C | Avvakumov GV | Bochkarev A | Dhe-Paganon S | Edwards A | Mackenzie F | Newman EM | Sundstrom M | Walker JR | Xue S
