1dkk

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (09:51, 20 March 2024) (edit) (undo)
 
(14 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1dkk.gif|left|200px]]
 
-
<!--
+
==BOBWHITE QUAIL LYSOZYME WITH NITRATE==
-
The line below this paragraph, containing "STRUCTURE_1dkk", creates the "Structure Box" on the page.
+
<StructureSection load='1dkk' size='340' side='right'caption='[[1dkk]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1dkk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Colinus_virginianus Colinus virginianus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DKK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DKK FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr>
-
{{STRUCTURE_1dkk| PDB=1dkk | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dkk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dkk OCA], [https://pdbe.org/1dkk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dkk RCSB], [https://www.ebi.ac.uk/pdbsum/1dkk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dkk ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/LYSC_COLVI LYSC_COLVI] Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents.
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dk/1dkk_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1dkk ConSurf].
 +
<div style="clear:both"></div>
-
'''BOBWHITE QUAIL LYSOZYME WITH NITRATE'''
+
==See Also==
-
 
+
*[[Lysozyme 3D structures|Lysozyme 3D structures]]
-
 
+
__TOC__
-
==Overview==
+
</StructureSection>
-
The HyHEL-5 antibody has more than a thousandfold lower affinity for bobwhite quail lysozyme (BWQL) than for hen egg-white lysozyme (HEL). Four sequence differences exist between BWQL and HEL, of which only one is involved in the interface with the Fab. The structure of bobwhite quail lysozyme has been determined in the uncomplexed state in two different crystal forms and in the complexed state with HyHEL-5, an antihen egg-white lysozyme Fab. Similar backbone conformations are observed in the three molecules of the two crystal forms of uncomplexed BWQL, although they show considerable variability in side-chain conformation. A relatively mobile segment in uncomplexed BWQL is observed to be part of the HyHEL-5 epitope. No major backbone conformational differences are observed in the lysozyme upon complex formation, but side-chain conformational differences are seen in surface residues that are involved in the interface with the antibody. The hydrogen bonding in the interface between BWQL and HyHEL-5 is similar to that in previously determined lysozyme-HyHEL-5 complexes.
+
-
 
+
-
==About this Structure==
+
-
1DKK is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Colinus_virginianus Colinus virginianus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DKK OCA].
+
-
 
+
-
==Reference==
+
-
Refined structures of bobwhite quail lysozyme uncomplexed and complexed with the HyHEL-5 Fab fragment., Chacko S, Silverton EW, Smith-Gill SJ, Davies DR, Shick KA, Xavier KA, Willson RC, Jeffrey PD, Chang CY, Sieker LC, Sheriff S, Proteins. 1996 Sep;26(1):55-65. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8880929 8880929]
+
[[Category: Colinus virginianus]]
[[Category: Colinus virginianus]]
-
[[Category: Lysozyme]]
+
[[Category: Large Structures]]
-
[[Category: Single protein]]
+
[[Category: Jeffrey PD]]
-
[[Category: Jeffrey, P D.]]
+
[[Category: Sheriff S]]
-
[[Category: Sheriff, S.]]
+
-
[[Category: Bacteriolytic enzyme]]
+
-
[[Category: Glycosidase]]
+
-
[[Category: Hydrolase]]
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 13:57:24 2008''
+

Current revision

BOBWHITE QUAIL LYSOZYME WITH NITRATE

PDB ID 1dkk

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1dkk"
Personal tools