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7bml
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of outer surface protein C (OspC) from Borrelia burgdorferi== | |
| + | <StructureSection load='7bml' size='340' side='right'caption='[[7bml]], [[Resolution|resolution]] 1.85Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[7bml]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Borreliella_burgdorferi Borreliella burgdorferi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7BML OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7BML FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7bml FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7bml OCA], [https://pdbe.org/7bml PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7bml RCSB], [https://www.ebi.ac.uk/pdbsum/7bml PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7bml ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/OSPC2_BORBG OSPC2_BORBG] Major immunodominant protein in mammalian hosts. Required for initial stages of mammalian infection. Inhibits macrophage-mediated phagocytosis of the bacteria. Binds human plasminogen; this probably confers an extracellular protease activity on the bacteria that allows it to traverse tissue. Interaction with tick I.ricinus salivary protein Salp15 protects the bacteria from antibody-mediated killing in vitro and in vivo.[UniProtKB:Q07337] | ||
| - | + | ==See Also== | |
| - | + | *[[Outer surface protein|Outer surface protein]] | |
| - | + | __TOC__ | |
| - | [[Category: | + | </StructureSection> |
| + | [[Category: Borreliella burgdorferi]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Bierwagen P]] | ||
| + | [[Category: Jaskolski M]] | ||
| + | [[Category: Ruszkowski M]] | ||
| + | [[Category: Sliwiak J]] | ||
| + | [[Category: Urbanowicz A]] | ||
Current revision
Crystal structure of outer surface protein C (OspC) from Borrelia burgdorferi
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