6lsz
From Proteopedia
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==HSP 90 in complex with Ganetespib== | ==HSP 90 in complex with Ganetespib== | ||
| - | <StructureSection load='6lsz' size='340' side='right'caption='[[6lsz]]' scene=''> | + | <StructureSection load='6lsz' size='340' side='right'caption='[[6lsz]], [[Resolution|resolution]] 1.99Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LSZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6LSZ FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[6lsz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LSZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6LSZ FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6lsz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lsz OCA], [https://pdbe.org/6lsz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6lsz RCSB], [https://www.ebi.ac.uk/pdbsum/6lsz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6lsz ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.992Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TUH:5-[2,4-DIHYDROXY-5-(PROPAN-2-YL)PHENYL]-4-(1-METHYL-1H-INDOL-5-YL)-2,4-DIHYDRO-3H-1,2,4-TRIAZOL-3-ONE'>TUH</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6lsz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lsz OCA], [https://pdbe.org/6lsz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6lsz RCSB], [https://www.ebi.ac.uk/pdbsum/6lsz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6lsz ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Heat Shock Protein structures|Heat Shock Protein structures]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Cao HL]] | [[Category: Cao HL]] | ||
Current revision
HSP 90 in complex with Ganetespib
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