2b1f

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (09:15, 14 February 2024) (edit) (undo)
 
(One intermediate revision not shown.)
Line 3: Line 3:
<StructureSection load='2b1f' size='340' side='right'caption='[[2b1f]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
<StructureSection load='2b1f' size='340' side='right'caption='[[2b1f]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[2b1f]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B1F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2B1F FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[2b1f]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B1F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2B1F FirstGlance]. <br>
-
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2zta|2zta]], [[1gcm|1gcm]], [[1gcl|1gcl]], [[2b22|2b22]]</div></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">GCN4, AAS3, ARG9 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2b1f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b1f OCA], [https://pdbe.org/2b1f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2b1f RCSB], [https://www.ebi.ac.uk/pdbsum/2b1f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2b1f ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2b1f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b1f OCA], [https://pdbe.org/2b1f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2b1f RCSB], [https://www.ebi.ac.uk/pdbsum/2b1f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2b1f ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
-
[[https://www.uniprot.org/uniprot/GCN4_YEAST GCN4_YEAST]] Is a transcription factor that is responsible for the activation of more than 30 genes required for amino acid or for purine biosynthesis in response to amino acid or purine starvation. Binds and recognize the DNA sequence: 5'-TGA[CG]TCA-3'.
+
[https://www.uniprot.org/uniprot/GCN4_YEAST GCN4_YEAST] Is a transcription factor that is responsible for the activation of more than 30 genes required for amino acid or for purine biosynthesis in response to amino acid or purine starvation. Binds and recognize the DNA sequence: 5'-TGA[CG]TCA-3'.
-
<div style="background-color:#fffaf0;">
+
-
== Publication Abstract from PubMed ==
+
-
Coiled-coil sequences in proteins commonly share a seven-amino acid repeat with nonpolar side chains at the first (a) and fourth (d) positions. We investigate here the role of a 3-3-1 hydrophobic repeat containing nonpolar amino acids at the a, d, and g positions in determining the structures of coiled coils using mutants of the GCN4 leucine zipper dimerization domain. When three charged residues at the g positions in the parental sequence are replaced by nonpolar alanine or valine side chains, stable four-helix structures result. The X-ray crystal structures of the tetramers reveal antiparallel, four-stranded coiled coils in which the a, d, and g side chains interlock in a combination of knobs-into-knobs and knobs-into-holes packing. Interfacial interactions in a coiled coil can therefore be prescribed by hydrophobic-polar patterns beyond the canonical 3-4 heptad repeat. The results suggest that the conserved, charged residues at the g positions in the GCN4 leucine zipper can impart a negative design element to disfavor thermodynamically more stable, antiparallel tetramers.
+
-
 
+
-
Antiparallel four-stranded coiled coil specified by a 3-3-1 hydrophobic heptad repeat.,Deng Y, Liu J, Zheng Q, Eliezer D, Kallenbach NR, Lu M Structure. 2006 Feb;14(2):247-55. PMID:16472744<ref>PMID:16472744</ref>
+
-
 
+
-
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+
-
</div>
+
-
<div class="pdbe-citations 2b1f" style="background-color:#fffaf0;"></div>
+
==See Also==
==See Also==
 +
*[[Gcn4 3D Structures|Gcn4 3D Structures]]
*[[Gnc4 3D Structures|Gnc4 3D Structures]]
*[[Gnc4 3D Structures|Gnc4 3D Structures]]
-
== References ==
 
-
<references/>
 
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Atcc 18824]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
-
[[Category: Deng, Y]]
+
[[Category: Saccharomyces cerevisiae]]
-
[[Category: Eliezer, D]]
+
[[Category: Deng Y]]
-
[[Category: Kallenbach, N R]]
+
[[Category: Eliezer D]]
-
[[Category: Liu, J]]
+
[[Category: Kallenbach NR]]
-
[[Category: Lu, M]]
+
[[Category: Liu J]]
-
[[Category: Zheng, Q]]
+
[[Category: Lu M]]
-
[[Category: Ala coil]]
+
[[Category: Zheng Q]]
-
[[Category: Antiparallel tetramer]]
+
-
[[Category: Biosynthetic protein]]
+
-
[[Category: Coiled coil]]
+
-
[[Category: Protein design]]
+
-
[[Category: Protein structure]]
+

Current revision

Antiparallel four-stranded coiled coil specified by a 3-3-1 hydrophobic heptad repeat

PDB ID 2b1f

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2b1f"
Personal tools