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Replication protein E1
From Proteopedia
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| - | <StructureSection load='1ksx' size='340' side='right' caption='Bovine papillomavirus 1 replication protein E1 complex with DNA (PDB code [[1ksx]])' scene=''> | + | <StructureSection load='1ksx' size='340' side='right' caption='Bovine papillomavirus 1 replication protein E1 complex with DNA (PDB code [[1ksx]])' scene='87/873777/Cv/1'> |
==Function== | ==Function== | ||
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== Structural highlights == | == Structural highlights == | ||
| - | The complex between BPV1 DBD and 21-bp DNA (PDB code [[1ksx]]) shows 2 DBD-DNA binding modules: a binding loop and a binding helix each interacting with a single strand. The protein-DNA interactions are hydrophilic to phosphate atoms and van der Waals hydrophobic ones<ref>PMID:11889054</ref>. | + | The complex between BPV1 DBD and 21-bp DNA (PDB code [[1ksx]]) shows 2 DBD-DNA binding modules: a <scene name='87/873777/Cv/2'>binding loop</scene> and a <scene name='87/873777/Cv/4'>binding helix</scene> each interacting with a single strand. The protein-DNA interactions are hydrophilic to phosphate atoms and van der Waals hydrophobic ones<ref>PMID:11889054</ref>. |
</StructureSection> | </StructureSection> | ||
==3D structures of replication protein E1== | ==3D structures of replication protein E1== | ||
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Domains: helicase 301-605; DNA-binding (DBD) 286-365 | Domains: helicase 301-605; DNA-binding (DBD) 286-365 | ||
| - | [[1r9w]] - | + | [[1r9w]] - HpvRPE1 DBD – Human papilloma virus 18<br /> |
| - | [[1tue]] - | + | [[1tue]] - HpvRPE1 428-631 (mutant) + RPE2 TAD<br /> |
| - | [[ | + | [[2gxa]] - DpvRPE1 helicase domain + DNA + ADP – Delta papilloma virus 4<br /> |
| - | [[5a9k]] - | + | [[5a9k]] - BpvRPE1 helicase domain – Bovine papilloma virus - Cryo EM<br /> |
| - | [[ | + | [[2v9p]] - BpvRPE1 helicase domain <br /> |
| - | [[1f08]] - | + | [[1f08]] - BpvRPE1 DBD<br /> |
| - | [[1ksx]], [[1ksy]] - | + | [[1ksx]], [[1ksy]] - BpvRPE1 DBD + DNA<br /> |
| + | [[7apd]] - BpvRPE1 helicase domain + DNA – Cryo EM<br /> | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Current revision
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3D structures of replication protein E1
Updated on 13-February-2022
Domains: helicase 301-605; DNA-binding (DBD) 286-365
1r9w - HpvRPE1 DBD – Human papilloma virus 18
1tue - HpvRPE1 428-631 (mutant) + RPE2 TAD
2gxa - DpvRPE1 helicase domain + DNA + ADP – Delta papilloma virus 4
5a9k - BpvRPE1 helicase domain – Bovine papilloma virus - Cryo EM
2v9p - BpvRPE1 helicase domain
1f08 - BpvRPE1 DBD
1ksx, 1ksy - BpvRPE1 DBD + DNA
7apd - BpvRPE1 helicase domain + DNA – Cryo EM
References
- ↑ Wilson VG, West M, Woytek K, Rangasamy D. Papillomavirus E1 proteins: form, function, and features. Virus Genes. 2002 Jun;24(3):275-90. doi: 10.1023/a:1015336817836. PMID:12086149 doi:http://dx.doi.org/10.1023/a:1015336817836
- ↑ Baedyananda F, Chaiwongkot A, Bhattarakosol P. Elevated HPV16 E1 Expression Is Associated with Cervical Cancer Progression. Intervirology. 2017;60(5):171-180. doi: 10.1159/000487048. Epub 2018 Mar 1. PMID:29495005 doi:http://dx.doi.org/10.1159/000487048
- ↑ Enemark EJ, Stenlund A, Joshua-Tor L. Crystal structures of two intermediates in the assembly of the papillomavirus replication initiation complex. EMBO J. 2002 Mar 15;21(6):1487-96. PMID:11889054 doi:http://dx.doi.org/10.1093/emboj/21.6.1487
