TRAP dicarboxylate transporter, DctP subunit

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<StructureSection load='1ksx' size='340' side='right' caption='Bovine papillomavirus 1 replication protein E1 complex with DNA (PDB code [[1ksx]])' scene=''>
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<StructureSection load='4mhf' size='340' side='right' caption='DctP complex with glucuronate (PDB code [[4mhf]])' scene=''>
==Function==
==Function==
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'''TRAP dicarboxylate transporter, DctP subunit'''
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'''TRAP dicarboxylate transporter, DctP subunit''' is part of the tripartite ATP-dependent transporters which consist of three protiens: DctP, DctM and DctQ. DctP is a periplasmic C4-dicarboxylate-binding receptor<ref>PMID:10627041</ref>.
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<ref>PMID:12086149</ref>.
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== Disease ==
== Disease ==
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RPE1 has been shown to mitigate host cell defenses leading to the development of cancer induces apoptosis of its host cells<ref>PMID:29495005</ref>.
 
==Relevance==
==Relevance==
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The detection of RPE1 mRNA and promoter methylation may serve as cancer prognostic marker.
 
== Structural highlights ==
== Structural highlights ==
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The complex between BPV1 DBD and 21-bp DNA (PDB code [[1ksx]]) shows 2 DBD-DNA binding modules: a binding loop and a binding helix each interacting with a single strand. The protein-DNA interactions are hydrophilic to phosphate atoms and van der Waals hydrophobic ones<ref>PMID:11889054</ref>.
 
</StructureSection>
</StructureSection>
==3D structures of TRAP dicarboxylate transporter, DctP subunit==
==3D structures of TRAP dicarboxylate transporter, DctP subunit==
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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{{#tree:id=OrganizedByTopic|openlevels=0|
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*TRAP dicarboxylate transporter, DctP subunit
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**[[4pfi]] - DctP - ''Marinobacter hydrocarbonoclasticus''<br />
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**[[4pe3]] - RsDctP - ''Rhodobacter sphaeroides''<br />
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**[[4p1e]] - DctP - ''Escherichia fergusonii''<br />
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**[[4p47]] - OaDctP - ''Ochtrobactrum anthropi''<br />
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**[[4n6d]] - DsDctP - ''Desulfovibrio salexigens''<br />
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*TRAP dicarboxylate transporter, DctP subunit complex with glucuronate derivative
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Domains: helicase 301-605; DNA-binding (DBD) 286-365
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**[[4n91]] - DctP + glucuronate - ''Anaerococcus prevotii''<br />
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**[[4ovq]] - DctP + glucuronate - ''Roeobacter denitrificans''<br />
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**[[4ovr]] - DctP + galacturonate - ''Xanthobacter autotrophicus''<br />
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**[[4mig]] - PoDctP + galacturonate - ''Polaromonas''<br />
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**[[4mhf]] - PoDctP + glucuronate <br />
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**[[4p1l]], [[4p3l]] - CsDctP + glucuronate <br />
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**[[4x8r]] - RsDctP + glucuronate <br />
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**[[4xfe]] - DctP + glucuronate - ''Pseudomonas putida''<br />
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**[[4n15]] - BaDctP + glucuronate - ''Burkholderia ambifaria''<br />
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**[[4n17]] - BaDctP + galacturonate <br />
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[[4pfi]] - DctP - ''Marinobacter hydrocarbonoclasticus''<br />
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*TRAP dicarboxylate transporter, DctP subunit other complexes
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[[4n6d]] - DsDctP - ''Desulfovibrio salexigens''<br />
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[[4n6k]] - DsDctP + diglycerolphosphate<br />
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[[4nn3]] - DsDctP + orotate<br />
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[[4nhb]] - DctP + glycerolphosphate - ''Desulfovibrio desulfuricans''<br />
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[[4ngu]] - DctP + Ala-Ala - ''Desulfovibrio alaskensis''<br />
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[[4xeq]] - DctP + pantoate - ''Desulfovibrio vulgaris''<br />
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[[4mco]], [[4mev]] - DctP + malonate - ''Rhodoferax ferrireducens''<br />
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[[4ovt]] - DctP + fuconate - ''Ochtrobactrum anthropi''<br />
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[[5cm6]] - DctP + pyruvate - ''Pseudoalteromonas atlantica''<br />
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[[4n91]] - DctP + glucuronate - ''Anaerococcus prevotii''<br />
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[[4ovq]] - DctP + glucuronate - ''Roeobacter denitrificans''<br />
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[[4ovr]] - DctP + galacturonate - ''Xanthobacter autotrophicus''<br />
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[[4mig]] - PoDctP + galacturonate - ''Polaromonas''<br />
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[[4n8g]] - DctP + Ala-Ala - ''Chromohalobacter salexigens''<br />
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[[4ovs]] - DctP + succinate - ''Sulfurospirillum deleyianum''<br />
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[[4o94]] - DctP + succinate - ''Rhodopseudomonas palustris''<br />
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[[4pfr]] - RsDctP + malate - ''Rhodobacter sphaeroides''<br />
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[[4x8r]] - RsDctP + glucuronate <br />
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[[4xfe]] - DctP + glucuronate - ''Pseudomonas putida''<br />
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[[4o7m]] - DctP + malate - ''Shewanella loihica''<br />
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**[[4n6k]] - DsDctP + diglycerolphosphate<br />
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**[[4nn3]] - DsDctP + orotate<br />
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**[[4nhb]] - DctP + glycerolphosphate - ''Desulfovibrio desulfuricans''<br />
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**[[4ngu]] - DctP + Ala-Ala - ''Desulfovibrio alaskensis''<br />
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**[[4xeq]] - DctP + pantoate - ''Desulfovibrio vulgaris''<br />
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**[[4mco]], [[4mev]] - DctP + malonate - ''Rhodoferax ferrireducens''<br />
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**[[4ovt]] - OaDctP + fuconate<br />
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**[[5cm6]] - DctP + pyruvate - ''Pseudoalteromonas atlantica''<br />
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**[[4pdd]], [[4pdh]] - PoDctP + erythronate <br />
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**[[4mnc]], [[4mni]] - PoDctP + benzoyl formate <br />
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**[[4n8g]] - CsDctP + Ala-Ala - ''Chromohalobacter salexigens''<br />
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**[[4ovs]] - DctP + succinate - ''Sulfurospirillum deleyianum''<br />
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**[[4o94]] - RpDctP + succinate - ''Rhodopseudomonas palustris''<br />
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**[[4oan]] - RpDctP + acetolactate derivative<br />
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**[[4paf]], [[4pai]], [[4pbh]] - DctP + benzoate derivative - ''Ruegeria pomeroyi''<br />
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**[[4pfr]] - RsDctP + malate<br />
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**[[4o7m]] - SlDctP + malate - ''Shewanella loihica''<br />
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**[[4oa4]] - SlDctP + succinate <br />
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**[[4ln5]] - BaDctP + glycerol <br />
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**[[3fxb]] - DctP + ectoine - ''Silicibacter pomeroyi''<br />
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**[[4o8m]] - RsDctP + galactonate - ''Actinobacillus succinogenes''<br />
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**[[4p9k]] - ewDctP + erythronate - earthworm<br />
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**[[4pak]] - ewDctP + pantoate<br />
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}}
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

DctP complex with glucuronate (PDB code 4mhf)

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3D structures of TRAP dicarboxylate transporter, DctP subunit

Updated on 01-February-2021

References

  1. ↑ Rabus R, Jack DL, Kelly DJ, Saier MH Jr. TRAP transporters: an ancient family of extracytoplasmic solute-receptor-dependent secondary active transporters. Microbiology (Reading). 1999 Dec;145 ( Pt 12):3431-3445. doi:, 10.1099/00221287-145-12-3431. PMID:10627041 doi:http://dx.doi.org/10.1099/00221287-145-12-3431

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel

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