Ubiquitin activating enzyme
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<StructureSection load='1y8x' size='350' side='right' caption='Structure of human ubiquitin activating enzyme Uba3 subunit (green) complex with E2 Ubc12 (cyan) (PDB entry [[1y8x]])' scene='55/551218/Cv/1'> | <StructureSection load='1y8x' size='350' side='right' caption='Structure of human ubiquitin activating enzyme Uba3 subunit (green) complex with E2 Ubc12 (cyan) (PDB entry [[1y8x]])' scene='55/551218/Cv/1'> | ||
| - | + | __TOC__ | |
| - | '''Ubiquitin activating enzyme''' (Uba) or '''E1 enzyme''' catalyzes the first step in the ubiquitination of a protein tagged to be degraded by the proteasome. Ubiquitin activating enzyme (E1) and ATP produce a C-terminal acyl adenylated ubiquitin molecule which binds to ubiquitin conjugating enzyme (E2) (Ubc) cysteine<ref>PMID:7673335</ref>. The Ubc then binds to ubiquitin ligase (E3) via a conserved binding region. E3 catalyzes the transfer of ubiquitin from the Ubc-ubiquitin complex to a lysine residue of the target protein. '''Uba3''' is the catalytic subunit of NEDD8 activating enzyme and APPB1 is its regulatory subunit. Similar to ubiquitin and SUMO, NEDD8 binds to proteins after processing of its C-terminal. <br /> | + | ==Function== |
| - | + | '''Ubiquitin activating enzyme''' (Uba) or '''E1 enzyme''' catalyzes the first step in the ubiquitination of a protein tagged to be degraded by the proteasome. Ubiquitin activating enzyme (E1) and ATP produce a C-terminal acyl adenylated ubiquitin molecule which binds to ubiquitin conjugating enzyme (E2) (Ubc) cysteine<ref>PMID:7673335</ref>. The Ubc then binds to ubiquitin ligase (E3) via a conserved binding region. E3 catalyzes the transfer of ubiquitin from the Ubc-ubiquitin complex to a lysine residue of the target protein. | |
| + | *'''Uba1''' see [[Uba1]].<br /> | ||
| + | *'''Uba3''' is the catalytic subunit of NEDD8 activating enzyme and APPB1 is its regulatory subunit. Similar to ubiquitin and SUMO, NEDD8 binds to proteins after processing of its C-terminal. <br /> | ||
| + | *'''Uba6''' regulates the interferon-gamma production of T-cells by modulating NF-κB activation pathway<ref>PMID:35011668</ref>. | ||
| + | *'''Uba7''' is involved in interferon-stimulated gene 15 conjugation<ref>PMID:32218830</ref>. | ||
| + | *'''Ubiquitin-like 1 activating enzyme E1A''' and '''Ubiquitin-like modifier-activating enzyme 2''' are involved in SUMOylation<ref>PMID:33477333</ref>,<ref>PMID:38172132</ref>. | ||
For '''ubiquitin-like modifier-activating enzyme Atg7''' see [[Autophagy-related protein]] | For '''ubiquitin-like modifier-activating enzyme Atg7''' see [[Autophagy-related protein]] | ||
<scene name='55/551218/Cv/2'>Structure of human ubiquitin activating enzyme Uba3 subunit complex with E2 Ubc12</scene> (PDB entry [[1y8x]]). <scene name='55/551218/Cv/4'>Uba3/E2 Ubc12 interactions</scene>. | <scene name='55/551218/Cv/2'>Structure of human ubiquitin activating enzyme Uba3 subunit complex with E2 Ubc12</scene> (PDB entry [[1y8x]]). <scene name='55/551218/Cv/4'>Uba3/E2 Ubc12 interactions</scene>. | ||
==[[3D structures of Ubiquitin activating enzyme]]== | ==[[3D structures of Ubiquitin activating enzyme]]== | ||
| - | </StructureSection> | ||
==References== | ==References== | ||
<references /> | <references /> | ||
| + | </StructureSection> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
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