1dm9

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (06:56, 7 February 2024) (edit) (undo)
 
(13 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1dm9.gif|left|200px]]
 
-
<!--
+
==HEAT SHOCK PROTEIN 15 KD==
-
The line below this paragraph, containing "STRUCTURE_1dm9", creates the "Structure Box" on the page.
+
<StructureSection load='1dm9' size='340' side='right'caption='[[1dm9]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1dm9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DM9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DM9 FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-
{{STRUCTURE_1dm9| PDB=1dm9 | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dm9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dm9 OCA], [https://pdbe.org/1dm9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dm9 RCSB], [https://www.ebi.ac.uk/pdbsum/1dm9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dm9 ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/HSLR_ECOLI HSLR_ECOLI] Involved in the recycling of free 50S ribosomal subunits that still carry a nascent chain. Binds RNA more specifically than DNA. Binds with very high affinity to the free 50S ribosomal subunit. Does not bind it when it is part of the 70S ribosome.
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dm/1dm9_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1dm9 ConSurf].
 +
<div style="clear:both"></div>
-
'''HEAT SHOCK PROTEIN 15 KD'''
+
==See Also==
-
 
+
*[[Heat Shock Protein structures|Heat Shock Protein structures]]
-
 
+
__TOC__
-
==Overview==
+
</StructureSection>
-
We have solved the crystal structure of the heat shock protein Hsp15, a newly isolated and very highly inducible heat shock protein that binds the ribosome. Comparison of its structure with those of two RNA-binding proteins, ribosomal protein S4 and threonyl-tRNA synthetase, reveals a novel RNA-binding motif. This newly recognized motif is remarkably common, present in at least eight different protein families that bind RNA. The motif's surface is populated by conserved, charged residues that define a likely RNA-binding site. An intriguing pattern emerges: stress proteins, ribosomal proteins and tRNA synthetases repeatedly share a conserved motif. This may imply a hitherto unrecognized functional similarity between these three protein classes.
+
-
 
+
-
==About this Structure==
+
-
1DM9 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DM9 OCA].
+
-
 
+
-
==Reference==
+
-
Structure of Hsp15 reveals a novel RNA-binding motif., Staker BL, Korber P, Bardwell JC, Saper MA, EMBO J. 2000 Feb 15;19(4):749-57. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10675344 10675344]
+
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
-
[[Category: Single protein]]
+
[[Category: Large Structures]]
-
[[Category: Bardwell, J C.A.]]
+
[[Category: Bardwell JCA]]
-
[[Category: Korber, P.]]
+
[[Category: Korber P]]
-
[[Category: Saper, M A.]]
+
[[Category: Saper MA]]
-
[[Category: Staker, B L.]]
+
[[Category: Staker BL]]
-
[[Category: Heat shock protein]]
+
-
[[Category: Protein-rna interaction]]
+
-
[[Category: Ribosome]]
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 14:00:53 2008''
+

Current revision

HEAT SHOCK PROTEIN 15 KD

PDB ID 1dm9

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1dm9"
Personal tools