2b9z

From Proteopedia

(Difference between revisions)

Current revision

Solution structure of FHV B2, a viral suppressor of RNAi

Structural highlights

2b9z is a 2 chain structure with sequence from Flock House virus. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	Solution NMR
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

B2_FHV Binds double-strand RNA (dsRNA) with high affinity. Suppresses the host RNA silencing-based antiviral response.^[1] ^[2]

Publication Abstract from PubMed

We report the structure of the flock house virus B2 protein, a potent suppressor of RNA interference (RNAi) in animals and plants. The B2 protein is a homodimer in solution and contains three alpha-helices per monomer. Chemical shift perturbation shows that an antiparallel arrangement of helices (alpha2/alpha2') forms an elongated binding interface with double-stranded RNA (dsRNA). This implies a novel mode of dsRNA recognition and provides insights into the mechanism of RNAi suppression by B2.

The structure of the flock house virus B2 protein, a viral suppressor of RNA interference, shows a novel mode of double-stranded RNA recognition.,Lingel A, Simon B, Izaurralde E, Sattler M EMBO Rep. 2005 Dec;6(12):1149-55. PMID:16270100^[3]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Li WX, Li H, Lu R, Li F, Dus M, Atkinson P, Brydon EW, Johnson KL, Garcia-Sastre A, Ball LA, Palese P, Ding SW. Interferon antagonist proteins of influenza and vaccinia viruses are suppressors of RNA silencing. Proc Natl Acad Sci U S A. 2004 Feb 3;101(5):1350-5. Epub 2004 Jan 26. PMID:14745017 doi:http://dx.doi.org/10.1073/pnas.0308308100
↑ Chao JA, Lee JH, Chapados BR, Debler EW, Schneemann A, Williamson JR. Dual modes of RNA-silencing suppression by Flock House virus protein B2. Nat Struct Mol Biol. 2005 Nov;12(11):952-7. PMID:16228003 doi:10.1038/nsmb1005
↑ Lingel A, Simon B, Izaurralde E, Sattler M. The structure of the flock house virus B2 protein, a viral suppressor of RNA interference, shows a novel mode of double-stranded RNA recognition. EMBO Rep. 2005 Dec;6(12):1149-55. PMID:16270100

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 See Also
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2b9z"

@@ Line 1: / Line 1: @@
 ==Solution structure of FHV B2, a viral suppressor of RNAi==
-<StructureSection load='2b9z' size='340' side='right'caption='[[2b9z]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
+<StructureSection load='2b9z' size='340' side='right'caption='[[2b9z]]' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2b9z]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Fhv Fhv]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B9Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2B9Z FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2b9z]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Flock_House_virus Flock House virus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B9Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2B9Z FirstGlance]. <br>
-</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">B2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=12287 FHV])</td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
 <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2b9z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b9z OCA], [https://pdbe.org/2b9z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2b9z RCSB], [https://www.ebi.ac.uk/pdbsum/2b9z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2b9z ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[https://www.uniprot.org/uniprot/B2_FHV B2_FHV]] Binds double-strand RNA (dsRNA) with high affinity. Suppresses the host RNA silencing-based antiviral response.<ref>PMID:14745017</ref> <ref>PMID:16228003</ref>
+[https://www.uniprot.org/uniprot/B2_FHV B2_FHV] Binds double-strand RNA (dsRNA) with high affinity. Suppresses the host RNA silencing-based antiviral response.<ref>PMID:14745017</ref> <ref>PMID:16228003</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 24: / Line 24: @@
 *[[Suppression of RNA Silencing by Viruses|Suppression of RNA Silencing by Viruses]]
 *[[Tomato aspermy virus protein 2b Suppression of RNA Silencing|Tomato aspermy virus protein 2b Suppression of RNA Silencing]]
-*[[User:Wayne Decatur/Flock house virus B2 protein Suppression of RNA Silencing|User:Wayne Decatur/Flock house virus B2 protein Suppression of RNA Silencing]]
-*[[User:Wayne Decatur/Plant Viral Protein p19 Suppression of RNA Silencing|User:Wayne Decatur/Plant Viral Protein p19 Suppression of RNA Silencing]]
-*[[User:Wayne Decatur/Suppression of RNA Silencing by Viruses|User:Wayne Decatur/Suppression of RNA Silencing by Viruses]]
-*[[User:Wayne Decatur/Tomato aspermy virus protein 2b Suppression of RNA Silencing|User:Wayne Decatur/Tomato aspermy virus protein 2b Suppression of RNA Silencing]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Fhv]]
+[[Category: Flock House virus]]
 [[Category: Large Structures]]
-[[Category: Izaurralde, E]]
+[[Category: Izaurralde E]]
-[[Category: Lingel, A]]
+[[Category: Lingel A]]
-[[Category: Sattler, M]]
+[[Category: Sattler M]]
-[[Category: Simon, B]]
+[[Category: Simon B]]
-[[Category: All alpha-helical]]
-[[Category: Symmetric antiparallel homodimer]]
-[[Category: Viral protein]]

2b9z

From Proteopedia

Current revision

Solution structure of FHV B2, a viral suppressor of RNAi

Structural highlights

Function

Publication Abstract from PubMed

See Also

References

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Proteopedia Page Contributors and Editors (what is this?)

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