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2bdu

From Proteopedia

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Current revision (11:21, 22 May 2024) (edit) (undo)
 
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<StructureSection load='2bdu' size='340' side='right'caption='[[2bdu]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
<StructureSection load='2bdu' size='340' side='right'caption='[[2bdu]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2bdu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BDU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BDU FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2bdu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BDU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BDU FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.35&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Nt5c3 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/5'-nucleotidase 5'-nucleotidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.5 3.1.3.5] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bdu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bdu OCA], [https://pdbe.org/2bdu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bdu RCSB], [https://www.ebi.ac.uk/pdbsum/2bdu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bdu ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bdu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bdu OCA], [https://pdbe.org/2bdu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bdu RCSB], [https://www.ebi.ac.uk/pdbsum/2bdu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bdu ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/5NT3_MOUSE 5NT3_MOUSE]] Can act both as nucleotidase and as phosphotransferase (By similarity).
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[https://www.uniprot.org/uniprot/5NT3A_MOUSE 5NT3A_MOUSE] Nucleotidase which shows specific activity towards cytidine monophosphate (CMP) and 7-methylguanosine monophosphate (m(7)GMP). CMP seems to be the preferred substrate.[UniProtKB:Q9H0P0]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: 5'-nucleotidase]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Lk3 transgenic mice]]
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[[Category: Mus musculus]]
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[[Category: Bae, E]]
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[[Category: Bae E]]
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[[Category: Bingman, C A]]
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[[Category: Bingman CA]]
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[[Category: Bitto, E]]
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[[Category: Bitto E]]
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[[Category: Structural genomic]]
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[[Category: Han BW]]
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[[Category: Han, B W]]
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[[Category: Phillips Jr GN]]
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[[Category: Phillips, G N]]
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[[Category: Wesenberg GE]]
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[[Category: Wesenberg, G E]]
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[[Category: Aah38029]]
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[[Category: Bc038029]]
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[[Category: Cesg]]
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[[Category: Cytosolic 5'-nucleotidase iii]]
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[[Category: Hydrolase]]
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[[Category: Mm 158936]]
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[[Category: Nt5c3 protein]]
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[[Category: PSI, Protein structure initiative]]
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[[Category: Umph-1]]
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Current revision

X-Ray Structure of a Cytosolic 5'-Nucleotidase III from Mus Musculus MM.158936

PDB ID 2bdu

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