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2bfr

From Proteopedia

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Current revision (13:34, 13 December 2023) (edit) (undo)
 
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<StructureSection load='2bfr' size='340' side='right'caption='[[2bfr]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
<StructureSection load='2bfr' size='340' side='right'caption='[[2bfr]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2bfr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Arcfl Arcfl]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BFR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BFR FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2bfr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Archaeoglobus_fulgidus Archaeoglobus fulgidus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BFR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BFR FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=FME:N-FORMYLMETHIONINE'>FME</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=FME:N-FORMYLMETHIONINE'>FME</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1hjz|1hjz]], [[1vhu|1vhu]], [[2bfq|2bfq]]</div></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bfr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bfr OCA], [https://pdbe.org/2bfr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bfr RCSB], [https://www.ebi.ac.uk/pdbsum/2bfr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bfr ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bfr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bfr OCA], [https://pdbe.org/2bfr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bfr RCSB], [https://www.ebi.ac.uk/pdbsum/2bfr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bfr ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/Y1521_ARCFU Y1521_ARCFU]] Removes ADP-ribose from glutamate residues in proteins bearing a single ADP-ribose moiety. Inactive towards proteins bearing poly-ADP-ribose. Catalyzes removal of a phosphate group from ADP-ribose 1''-phosphate (Appr1p), but with low efficiency.<ref>PMID:23474712</ref> <ref>PMID:15902274</ref>
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[https://www.uniprot.org/uniprot/Y1521_ARCFU Y1521_ARCFU] Removes ADP-ribose from glutamate residues in proteins bearing a single ADP-ribose moiety. Inactive towards proteins bearing poly-ADP-ribose. Catalyzes removal of a phosphate group from ADP-ribose 1''-phosphate (Appr1p), but with low efficiency.<ref>PMID:23474712</ref> <ref>PMID:15902274</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Arcfl]]
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[[Category: Archaeoglobus fulgidus]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Allen, M D]]
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[[Category: Allen MD]]
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[[Category: Buhecha, H R]]
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[[Category: Buhecha HR]]
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[[Category: Bycroft, M]]
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[[Category: Bycroft M]]
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[[Category: Karras, G I]]
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[[Category: Karras GI]]
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[[Category: Ladurner, A G]]
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[[Category: Ladurner AG]]
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[[Category: Pugieux, C]]
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[[Category: Pugieux C]]
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[[Category: Sait, F]]
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[[Category: Sait F]]
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[[Category: Crystal structure p-loop]]
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[[Category: Histone macroh2a]]
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[[Category: Hydrolase]]
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[[Category: Macro_h2a domain-hydrolase complex]]
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[[Category: Macro_h2a domain/hydrolase]]
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[[Category: Nucleotide]]
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Current revision

The Macro domain is an ADP-ribose binding module

PDB ID 2bfr

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