2crf

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==Solution structure of the Ran_BP1 domain of RAN-binding protein-3==
==Solution structure of the Ran_BP1 domain of RAN-binding protein-3==
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<StructureSection load='2crf' size='340' side='right'caption='[[2crf]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='2crf' size='340' side='right'caption='[[2crf]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2crf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CRF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CRF FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2crf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CRF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CRF FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RANBP3 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2crf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2crf OCA], [https://pdbe.org/2crf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2crf RCSB], [https://www.ebi.ac.uk/pdbsum/2crf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2crf ProSAT], [https://www.topsan.org/Proteins/RSGI/2crf TOPSAN]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2crf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2crf OCA], [https://pdbe.org/2crf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2crf RCSB], [https://www.ebi.ac.uk/pdbsum/2crf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2crf ProSAT], [https://www.topsan.org/Proteins/RSGI/2crf TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/RANB3_HUMAN RANB3_HUMAN]] Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF-beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export.<ref>PMID:9637251</ref> <ref>PMID:11571268</ref> <ref>PMID:11425870</ref> <ref>PMID:11932251</ref> <ref>PMID:19289081</ref>
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[https://www.uniprot.org/uniprot/RANB3_HUMAN RANB3_HUMAN] Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF-beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export.<ref>PMID:9637251</ref> <ref>PMID:11571268</ref> <ref>PMID:11425870</ref> <ref>PMID:11932251</ref> <ref>PMID:19289081</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Hayashi, F]]
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[[Category: Hayashi F]]
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[[Category: Nagashima, T]]
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[[Category: Nagashima T]]
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[[Category: Structural genomic]]
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[[Category: Yokoyama S]]
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[[Category: Yokoyama, S]]
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[[Category: Zhang HP]]
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[[Category: Zhang, H P]]
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[[Category: National project on protein structural and functional analyse]]
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[[Category: Nppsfa]]
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[[Category: Ran-binding protein 3]]
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[[Category: Ran_bp1 domain]]
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[[Category: Ranbp3]]
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[[Category: Rsgi]]
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[[Category: Transport protein]]
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Current revision

Solution structure of the Ran_BP1 domain of RAN-binding protein-3

PDB ID 2crf

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