2djx

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Current revision (08:27, 25 October 2023) (edit) (undo)
 
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<StructureSection load='2djx' size='340' side='right'caption='[[2djx]], [[Resolution|resolution]] 1.58&Aring;' scene=''>
<StructureSection load='2djx' size='340' side='right'caption='[[2djx]], [[Resolution|resolution]] 1.58&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2djx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Trycr Trycr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DJX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DJX FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2djx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DJX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DJX FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=NCO:COBALT+HEXAMMINE(III)'>NCO</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.58&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2djl|2djl]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=NCO:COBALT+HEXAMMINE(III)'>NCO</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TCDHOD2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5693 TRYCR])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Dihydroorotate_oxidase_(fumarate) Dihydroorotate oxidase (fumarate)], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.98.1 1.3.98.1] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2djx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2djx OCA], [https://pdbe.org/2djx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2djx RCSB], [https://www.ebi.ac.uk/pdbsum/2djx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2djx ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2djx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2djx OCA], [https://pdbe.org/2djx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2djx RCSB], [https://www.ebi.ac.uk/pdbsum/2djx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2djx ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PYRD_TRYCC PYRD_TRYCC] Catalyzes the conversion of dihydroorotate to orotate with fumarate as the electron acceptor. Molecular oxygen can replace fumarate in vitro.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Trycr]]
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[[Category: Trypanosoma cruzi]]
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[[Category: Aoki, T]]
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[[Category: Aoki T]]
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[[Category: Harada, S]]
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[[Category: Harada S]]
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[[Category: Inaoka, D K]]
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[[Category: Inaoka DK]]
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[[Category: Kita, K]]
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[[Category: Kita K]]
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[[Category: Kurisu, G]]
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[[Category: Kurisu G]]
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[[Category: Nara, T]]
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[[Category: Nara T]]
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[[Category: Sakamoto, K]]
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[[Category: Sakamoto K]]
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[[Category: Shiba, T]]
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[[Category: Shiba T]]
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[[Category: Shimizu, H]]
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[[Category: Shimizu H]]
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[[Category: Chagas' disease]]
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[[Category: Energy metabolism]]
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[[Category: Flavoprotein]]
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[[Category: Fumarate reductase]]
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[[Category: Oxidoreductase]]
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[[Category: Pyrimidine biosynthesis]]
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[[Category: Redox homeostasis]]
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Current revision

Crystal structure of native Trypanosoma cruzi dihydroorotate dehydrogenase

PDB ID 2djx

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