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7e14
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 7e14 is ON HOLD Authors: Cong, Z.T., Chen, L.N., Ma, H.L., Yang, D.H., Xu, H.E., Zhang, Y., Wang, M.W. Description: Compound2_GLP-1R_OWL833_Gs comp...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Compound2_GLP-1R_OWL833_Gs complex structure== | |
| + | <StructureSection load='7e14' size='340' side='right'caption='[[7e14]], [[Resolution|resolution]] 2.90Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[7e14]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus], [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7E14 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7E14 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.9Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=HNO:N-tert-butyl-6,7-bis(chloranyl)quinoxalin-2-amine'>HNO</scene>, <scene name='pdbligand=V6G:3-[(1S,2S)-1-(5-[(4S)-2,2-dimethyloxan-4-yl]-2-{(4S)-2-(4-fluoro-3,5-dimethylphenyl)-3-[3-(4-fluoro-1-methyl-1H-indazol-5-yl)-2-oxo-2,3-dihydro-1H-imidazol-1-yl]-4-methyl-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carbonyl}-1H-indol-1-yl)-2-methylcyclopropyl]-1,2,4-oxadiazol-5(4H)-one'>V6G</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7e14 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7e14 OCA], [https://pdbe.org/7e14 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7e14 RCSB], [https://www.ebi.ac.uk/pdbsum/7e14 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7e14 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/GBB1_HUMAN GBB1_HUMAN] Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.<ref>PMID:18611381</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Glucagon-like peptide receptor 3D structures|Glucagon-like peptide receptor 3D structures]] | |
| - | + | *[[Transducin 3D structures|Transducin 3D structures]] | |
| - | [[Category: | + | == References == |
| - | [[Category: | + | <references/> |
| - | [[Category: | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: | + | [[Category: Bos taurus]] |
| - | [[Category: Ma | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Rattus norvegicus]] |
| + | [[Category: Synthetic construct]] | ||
| + | [[Category: Chen LN]] | ||
| + | [[Category: Cong ZT]] | ||
| + | [[Category: Ma HL]] | ||
| + | [[Category: Wang MW]] | ||
| + | [[Category: Xu HE]] | ||
| + | [[Category: Yang DH]] | ||
| + | [[Category: Zhang Y]] | ||
Current revision
Compound2_GLP-1R_OWL833_Gs complex structure
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Categories: Bos taurus | Homo sapiens | Large Structures | Rattus norvegicus | Synthetic construct | Chen LN | Cong ZT | Ma HL | Wang MW | Xu HE | Yang DH | Zhang Y
