2e6l
From Proteopedia
(Difference between revisions)
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<StructureSection load='2e6l' size='340' side='right'caption='[[2e6l]], [[Resolution|resolution]] 2.20Å' scene=''> | <StructureSection load='2e6l' size='340' side='right'caption='[[2e6l]], [[Resolution|resolution]] 2.20Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2e6l]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[2e6l]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E6L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2E6L FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2e6l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e6l OCA], [https://pdbe.org/2e6l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2e6l RCSB], [https://www.ebi.ac.uk/pdbsum/2e6l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2e6l ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2e6l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e6l OCA], [https://pdbe.org/2e6l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2e6l RCSB], [https://www.ebi.ac.uk/pdbsum/2e6l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2e6l ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/WRN_MOUSE WRN_MOUSE] Multifunctional enzyme that has both magnesium and ATP-dependent DNA-helicase activity and 3'->5' exonuclease activity towards double-stranded DNA with a 5'-overhang. Has no nuclease activity towards single-stranded DNA or blunt-ended double-stranded DNA. Binds preferentially to DNA substrates containing alternate secondary structures, such as replication forks and Holliday junctions. May play an important role in the dissociation of joint DNA molecules that can arise as products of homologous recombination, at stalled replication forks or during DNA repair. Alleviates stalling of DNA polymerases at the site of DNA lesions. Important for genomic integrity. Plays a role in the formation of DNA replication focal centers; stably associates with foci elements generating binding sites for RP-A (By similarity).<ref>PMID:10757812</ref> <ref>PMID:17229737</ref> | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Mus musculus]] |
| - | [[Category: Cho | + | [[Category: Cho Y]] |
| - | [[Category: Choi | + | [[Category: Choi JM]] |
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Current revision
structure of mouse WRN exonuclease domain
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