7lmt

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "7lmt" [edit=sysop:move=sysop])
Current revision (15:54, 18 October 2023) (edit) (undo)
 
(One intermediate revision not shown.)
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 7lmt is ON HOLD
+
==Histone-lysine N-methyltransferase NSD2-PWWP1 with compound MRT10241866a==
-
 
+
<StructureSection load='7lmt' size='340' side='right'caption='[[7lmt]], [[Resolution|resolution]] 2.27&Aring;' scene=''>
-
Authors: Lei, M., Freitas, R.F., Dong, A., Schapira, M., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[7lmt]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7LMT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7LMT FirstGlance]. <br>
-
Description: Histone-lysine N-methyltransferase NSD2-PWWP1 with compound MRT10241866a
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.27&#8491;</td></tr>
-
[[Category: Unreleased Structures]]
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>, <scene name='pdbligand=Y6V:~{N}-cyclopropyl-3-oxidanylidene-~{N}-(thiophen-2-ylmethyl)-4~{H}-1,4-benzoxazine-7-carboxamide'>Y6V</scene></td></tr>
-
[[Category: Freitas, R.F]]
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7lmt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lmt OCA], [https://pdbe.org/7lmt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lmt RCSB], [https://www.ebi.ac.uk/pdbsum/7lmt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lmt ProSAT]</span></td></tr>
-
[[Category: Schapira, M]]
+
</table>
-
[[Category: Min, J]]
+
== Disease ==
-
[[Category: Edwards, A.M]]
+
[https://www.uniprot.org/uniprot/NSD2_HUMAN NSD2_HUMAN] Wolf-Hirschhorn syndrome. A chromosomal aberration involving WHSC1 is a cause of multiple myeloma tumors. Translocation t(4;14)(p16.3;q32.3) with IgH. WHSC1 is located in the Wolf-Hirschhorn syndrome (WHS) critical region. WHS results from by sub-telomeric deletions in the short arm of chromosome 4. WHSC1 is deleted in every case, however deletion of linked genes contributes to both the severity of the core characteristics and the presence of the additional syndromic problems.
-
[[Category: Arrowsmith, C.H]]
+
== Function ==
-
[[Category: Dong, A]]
+
[https://www.uniprot.org/uniprot/NSD2_HUMAN NSD2_HUMAN] Histone methyltransferase with histone H3 'Lys-27' (H3K27me) methyltransferase activity. Isoform 2 may act as a transcription regulator that binds DNA and suppresses IL5 transcription through HDAC recruitment.<ref>PMID:11152655</ref> <ref>PMID:16115125</ref> <ref>PMID:18172012</ref>
-
[[Category: Structural Genomics Consortium (Sgc)]]
+
== References ==
-
[[Category: Lei, M]]
+
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Homo sapiens]]
 +
[[Category: Large Structures]]
 +
[[Category: Arrowsmith CH]]
 +
[[Category: Dong A]]
 +
[[Category: Edwards AM]]
 +
[[Category: Freitas RF]]
 +
[[Category: Lei M]]
 +
[[Category: Min J]]
 +
[[Category: Schapira M]]

Current revision

Histone-lysine N-methyltransferase NSD2-PWWP1 with compound MRT10241866a

PDB ID 7lmt

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/7lmt"
Personal tools