7lf6

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'''Unreleased structure'''
 
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The entry 7lf6 is ON HOLD until Paper Publication
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==Structure of lysosomal membrane protein==
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<StructureSection load='7lf6' size='340' side='right'caption='[[7lf6]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
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Authors: Shen, C., Fu, T.M., Wang, L.F., Rawson, S., Wu, H.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[7lf6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7LF6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7LF6 FirstGlance]. <br>
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Description: Structure of lysosomal membrane protein
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.5&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7lf6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lf6 OCA], [https://pdbe.org/7lf6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lf6 RCSB], [https://www.ebi.ac.uk/pdbsum/7lf6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lf6 ProSAT]</span></td></tr>
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[[Category: Wang, L.F]]
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</table>
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[[Category: Rawson, S]]
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== Disease ==
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[[Category: Fu, T.M]]
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[https://www.uniprot.org/uniprot/TM175_HUMAN TM175_HUMAN] Disease susceptibility may be associated with variations affecting the gene represented in this entry. TMEM175 defects result in unstable lysosomal pH, leading to decreased lysosomal catalytic activity, decreased glucocerebrosidase activity, impaired autophagosome clearance by the lysosome and decreased mitochondrial respiration (PubMed:28193887).<ref>PMID:28193887</ref>
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[[Category: Wu, H]]
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== Function ==
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[[Category: Shen, C]]
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[https://www.uniprot.org/uniprot/TM175_HUMAN TM175_HUMAN] Organelle-specific potassium channel specifically responsible for potassium conductance in endosomes and lysosomes. Forms a potassium-permeable leak-like channel, which regulates lumenal pH stability and is required for autophagosome-lysosome fusion. Constitutes the major lysosomal potassium channel.<ref>PMID:26317472</ref> <ref>PMID:28723891</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Fu TM]]
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[[Category: Rawson S]]
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[[Category: Shen C]]
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[[Category: Wang LF]]
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[[Category: Wu H]]

Current revision

Structure of lysosomal membrane protein

PDB ID 7lf6

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OCA

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