7b5g

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'''Unreleased structure'''
 
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The entry 7b5g is ON HOLD until Paper Publication
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==Crystal structure of E.coli LexA in complex with nanobody NbSOS3(Nb14527)==
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<StructureSection load='7b5g' size='340' side='right'caption='[[7b5g]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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Authors: Maso, L., Vascon, F., Chinellato, M., Pardon, E., Steyaert, J., Angelini, A., Tondi, D., Cendron, L.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[7b5g]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12] and [https://en.wikipedia.org/wiki/Lama_glama Lama glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7B5G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7B5G FirstGlance]. <br>
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Description: Crystal structure of E.coli LexA in complex with nanobody NbSOS3(Nb14527)
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
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[[Category: Angelini, A]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7b5g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7b5g OCA], [https://pdbe.org/7b5g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7b5g RCSB], [https://www.ebi.ac.uk/pdbsum/7b5g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7b5g ProSAT]</span></td></tr>
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[[Category: Steyaert, J]]
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</table>
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[[Category: Chinellato, M]]
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== Function ==
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[[Category: Cendron, L]]
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[https://www.uniprot.org/uniprot/LEXA_ECOLI LEXA_ECOLI] Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. Binds to the 16 bp palindromic sequence 5'-CTGTATATATATACAG-3'. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.<ref>PMID:7027255</ref> <ref>PMID:7027256</ref>
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[[Category: Pardon, E]]
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== References ==
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[[Category: Vascon, F]]
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<references/>
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[[Category: Maso, L]]
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__TOC__
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[[Category: Tondi, D]]
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</StructureSection>
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[[Category: Escherichia coli K-12]]
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[[Category: Lama glama]]
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[[Category: Large Structures]]
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[[Category: Angelini A]]
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[[Category: Cendron L]]
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[[Category: Chinellato M]]
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[[Category: Maso L]]
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[[Category: Pardon E]]
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[[Category: Steyaert J]]
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[[Category: Tondi D]]
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[[Category: Vascon F]]

Current revision

Crystal structure of E.coli LexA in complex with nanobody NbSOS3(Nb14527)

PDB ID 7b5g

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