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1dth

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[[Image:1dth.gif|left|200px]]
 
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==METALLOPROTEASE==
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The line below this paragraph, containing "STRUCTURE_1dth", creates the "Structure Box" on the page.
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<StructureSection load='1dth' size='340' side='right'caption='[[1dth]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1dth]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Crotalus_atrox Crotalus atrox]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DTH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DTH FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BAT:4-(N-HYDROXYAMINO)-2R-ISOBUTYL-2S-(2-THIENYLTHIOMETHYL)SUCCINYL-L-PHENYLALANINE-N-METHYLAMIDE'>BAT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_1dth| PDB=1dth | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dth FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dth OCA], [https://pdbe.org/1dth PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dth RCSB], [https://www.ebi.ac.uk/pdbsum/1dth PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dth ProSAT]</span></td></tr>
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</table>
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'''METALLOPROTEASE'''
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== Function ==
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[https://www.uniprot.org/uniprot/VM1AD_CROAT VM1AD_CROAT] Snake venom zinc metalloproteinase that causes hemorrhage by provoking the degradation of the sub-endothelial matrix proteins (fibronectin, laminin, type IV collagen, nidogen, and gelatins).<ref>PMID:2817904</ref>
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== Evolutionary Conservation ==
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==Overview==
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[[Image:Consurf_key_small.gif|200px|right]]
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Matrix metalloproteinase enzymes have been implicated in degenerative processes like tumor cell invasion, metastasis, and arthritis. Specific metalloproteinase inhibitors have been used to block tumor cell proliferation. We have examined the interaction of batimastat (BB-94) with a metalloproteinase [atrolysin C (Ht-d), EC 3.4.24.42] active site at 2.0-angstroms resolution (R = 16.8%). The title structure exhibits an unexpected binding geometry, with the thiophene ring deeply inserted into the primary specificity site. This unprecedented binding geometry dramatizes the significance of the cavernous primary specificity site, pointing the way for the design of a new generation of potential antitumor drugs.
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Check<jmol>
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<jmolCheckbox>
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==About this Structure==
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dt/1dth_consurf.spt"</scriptWhenChecked>
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1DTH is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Crotalus_atrox Crotalus atrox]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DTH OCA].
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==Reference==
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</jmolCheckbox>
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Batimastat, a potent matrix mealloproteinase inhibitor, exhibits an unexpected mode of binding., Botos I, Scapozza L, Zhang D, Liotta LA, Meyer EF, Proc Natl Acad Sci U S A. 1996 Apr 2;93(7):2749-54. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8610113 8610113]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1dth ConSurf].
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[[Category: Atrolysin C]]
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Crotalus atrox]]
[[Category: Crotalus atrox]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Botos, I.]]
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[[Category: Botos I]]
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[[Category: Liotta, L A.]]
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[[Category: Liotta LA]]
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[[Category: Meyer, E F.]]
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[[Category: Meyer EF]]
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[[Category: Scapozza, L.]]
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[[Category: Scapozza L]]
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[[Category: Zhang, D.]]
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[[Category: Zhang D]]
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[[Category: Hydrolase]]
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[[Category: Metalloprotease]]
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[[Category: Venom]]
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[[Category: Zinc]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 14:15:17 2008''
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Current revision

METALLOPROTEASE

PDB ID 1dth

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