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6o5z

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Current revision (07:05, 11 October 2023) (edit) (undo)
 
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<StructureSection load='6o5z' size='340' side='right'caption='[[6o5z]], [[Resolution|resolution]] 2.29&Aring;' scene=''>
<StructureSection load='6o5z' size='340' side='right'caption='[[6o5z]], [[Resolution|resolution]] 2.29&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6o5z]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6O5Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6O5Z FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6o5z]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6O5Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6O5Z FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=LN4:1-[2-fluoranyl-5-(trifluoromethyl)phenyl]-3-[4-[methyl-[2-[(3-sulfamoylphenyl)amino]pyrimidin-4-yl]amino]phenyl]urea'>LN4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.285&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MLKL ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=LN4:1-[2-fluoranyl-5-(trifluoromethyl)phenyl]-3-[4-[methyl-[2-[(3-sulfamoylphenyl)amino]pyrimidin-4-yl]amino]phenyl]urea'>LN4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6o5z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6o5z OCA], [https://pdbe.org/6o5z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6o5z RCSB], [https://www.ebi.ac.uk/pdbsum/6o5z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6o5z ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6o5z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6o5z OCA], [https://pdbe.org/6o5z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6o5z RCSB], [https://www.ebi.ac.uk/pdbsum/6o5z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6o5z ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/MLKL_HUMAN MLKL_HUMAN]] Required for the execution of programmed necrosis.<ref>PMID:22265414</ref>
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[https://www.uniprot.org/uniprot/MLKL_HUMAN MLKL_HUMAN] Required for the execution of programmed necrosis.<ref>PMID:22265414</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Cowan, A D]]
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[[Category: Cowan AD]]
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[[Category: Czabotar, P E]]
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[[Category: Czabotar PE]]
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[[Category: Lessene, G L]]
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[[Category: Lessene GL]]
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[[Category: Murphy, J M]]
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[[Category: Murphy JM]]
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[[Category: Pierotti, C L]]
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[[Category: Pierotti CL]]
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[[Category: Inhibitor]]
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[[Category: Necroptosis]]
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[[Category: Pseudokinase]]
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[[Category: Transferase]]
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[[Category: Transferase-transferase inhibitor complex]]
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Current revision

Crystal Structure of the human MLKL pseudokinase domain bound to compound 2

PDB ID 6o5z

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