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1cix

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Current revision (11:39, 22 November 2023) (edit) (undo)
 
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==THREE-DIMENSIONAL STRUCTURE OF ANTIMICROBIAL PEPTIDE TACHYSTATIN A ISOLATED FROM HORSESHOE CRAB==
==THREE-DIMENSIONAL STRUCTURE OF ANTIMICROBIAL PEPTIDE TACHYSTATIN A ISOLATED FROM HORSESHOE CRAB==
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<StructureSection load='1cix' size='340' side='right'caption='[[1cix]], [[NMR_Ensembles_of_Models | 24 NMR models]]' scene=''>
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<StructureSection load='1cix' size='340' side='right'caption='[[1cix]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1cix]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Tachypleus_tridentatus Tachypleus tridentatus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CIX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CIX FirstGlance]. <br>
<table><tr><td colspan='2'>[[1cix]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Tachypleus_tridentatus Tachypleus tridentatus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CIX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CIX FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1cix FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cix OCA], [https://pdbe.org/1cix PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1cix RCSB], [https://www.ebi.ac.uk/pdbsum/1cix PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1cix ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1cix FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cix OCA], [https://pdbe.org/1cix PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1cix RCSB], [https://www.ebi.ac.uk/pdbsum/1cix PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1cix ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/TACA2_TACTR TACA2_TACTR]] Exhibits stronger antimicrobial activity against the Gram-positive bacteria (S.aureus (IC(50) is 4.2 ug/ml)) and fungi (C.albicans (IC(50) is 3.0 ug/ml) and P.pastoris (IC(50) is 0.5 ug/ml)) than Gram-negative bacteria (E.coli (IC(50) is 25 ug/ml)). Binds to chitin (8.4 uM are required to obtain 50% of binding). Does not cause hemolysis on sheep erythrocytes. Has no blocking activity on the P-type calcium channel.
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[https://www.uniprot.org/uniprot/TACA2_TACTR TACA2_TACTR] Exhibits stronger antimicrobial activity against the Gram-positive bacteria (S.aureus (IC(50) is 4.2 ug/ml)) and fungi (C.albicans (IC(50) is 3.0 ug/ml) and P.pastoris (IC(50) is 0.5 ug/ml)) than Gram-negative bacteria (E.coli (IC(50) is 25 ug/ml)). Binds to chitin (8.4 uM are required to obtain 50% of binding). Does not cause hemolysis on sheep erythrocytes. Has no blocking activity on the P-type calcium channel.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Tachypleus tridentatus]]
[[Category: Tachypleus tridentatus]]
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[[Category: Demura, M]]
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[[Category: Demura M]]
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[[Category: Fujitani, N]]
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[[Category: Fujitani N]]
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[[Category: Kawabata, S]]
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[[Category: Kawabata S]]
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[[Category: Kawano, K]]
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[[Category: Kawano K]]
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[[Category: Kumaki, Y]]
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[[Category: Kumaki Y]]
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[[Category: Nitta, K]]
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[[Category: Nitta K]]
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[[Category: Osaki, T]]
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[[Category: Osaki T]]
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[[Category: Antimicrobial peptide]]
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[[Category: Chitin-binding peptide]]
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Current revision

THREE-DIMENSIONAL STRUCTURE OF ANTIMICROBIAL PEPTIDE TACHYSTATIN A ISOLATED FROM HORSESHOE CRAB

PDB ID 1cix

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