Alcohol dehydrogenase 3D structures
From Proteopedia
(Difference between revisions)
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**[[3jv7]] – RrADH I – ''Rhodococcus rubber''<br /> | **[[3jv7]] – RrADH I – ''Rhodococcus rubber''<br /> | ||
**[[4w6z]] – yADH I – yeast<br /> | **[[4w6z]] – yADH I – yeast<br /> | ||
| + | **[[7kcq]] – yADH I – Cryo EM<br /> | ||
**[[4eex]] – LlADH I – ''Lactococcus lactis''<br /> | **[[4eex]] – LlADH I – ''Lactococcus lactis''<br /> | ||
**[[4eez]] – LlADH I (mutant) | **[[4eez]] – LlADH I (mutant) | ||
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**[[1u3w]] - hADH I γ chain + inhibitor<br /> | **[[1u3w]] - hADH I γ chain + inhibitor<br /> | ||
**[[1ht0]] - hADH I γ chain (mutant) + NAD<br /> | **[[1ht0]] - hADH I γ chain (mutant) + NAD<br /> | ||
| + | **[[7kc2]], [[7kjy]] – yADH I + NAD – Cryo EM<br /> | ||
**[[6c49]] – ADH I + Zn – ''Acinetobacter baumannii''<br /> | **[[6c49]] – ADH I + Zn – ''Acinetobacter baumannii''<br /> | ||
| + | **[[6qhe]] – ADH + NAD – Arthrobacter<br /> | ||
*ADH I ternary complex | *ADH I ternary complex | ||
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**[[1deh]], [[1hdy]] - hADH I β chain + NAD + pyrazole derivative<br /> | **[[1deh]], [[1hdy]] - hADH I β chain + NAD + pyrazole derivative<br /> | ||
**[[1htb]] - hADH I β3 chain + NAD + pyrazole derivative<br /> | **[[1htb]] - hADH I β3 chain + NAD + pyrazole derivative<br /> | ||
| - | **[[2xaa]] – RrADH I + NAD + alcohol<br /> | ||
| - | **[[6ffx]] – RrADH I + Zn + NAD<br /> | ||
| - | **[[6ffz]], [[5o8h]], [[5o8q]], [[5o9d]], [[5o9f]], [[6fg0]], [[5od3]] – RrADH I (mutant) + Zn + NAD<br /> | ||
**[[3fx4]] – pADH I + NADP + inhibitor – pig<br /> | **[[3fx4]] – pADH I + NADP + inhibitor – pig<br /> | ||
**[[4w6z]] – yADH I + Zn + NAD derivative<br /> | **[[4w6z]] – yADH I + Zn + NAD derivative<br /> | ||
**[[5env]] – yADH I + Zn + NAD + alcohol<br /> | **[[5env]] – yADH I + Zn + NAD + alcohol<br /> | ||
| + | **[[6ffx]] – RrADH I + Zn + NAD<br /> | ||
| + | **[[6ffz]], [[5o8h]], [[5o8q]], [[5o9d]], [[5o9f]], [[6fg0]], [[5od3]] – RrADH I (mutant) + Zn + NAD<br /> | ||
*ADH II | *ADH II | ||
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**[[3cos]] - hADH II + NAD + Zn<br /> | **[[3cos]] - hADH II + NAD + Zn<br /> | ||
| - | **[[3ox4]] - ZmADH II iron-dependent + NAD<br /> | ||
**[[1e3e]] – mADH II + NADH – mouse<br /> | **[[1e3e]] – mADH II + NADH – mouse<br /> | ||
**[[1e3l]] - mADH II (mutant) + NADH<br /> | **[[1e3l]] - mADH II (mutant) + NADH<br /> | ||
**[[1e3i]] - mADH II + NADH + inhibitor<br /> | **[[1e3i]] - mADH II + NADH + inhibitor<br /> | ||
**[[5yln]] – ADH II + Zn – ''Streptococcus pneumoniae''<br /> | **[[5yln]] – ADH II + Zn – ''Streptococcus pneumoniae''<br /> | ||
| + | **[[3ox4]] - ZmADH II iron-dependent + NAD<br /> | ||
*ADH III | *ADH III | ||
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**[[1ma0]] - hADH III χ chain + dodecanoic acid + NAD<br /> | **[[1ma0]] - hADH III χ chain + dodecanoic acid + NAD<br /> | ||
**[[3qj5]] - hADH III χ chain + inhibitor + NAD<br /> | **[[3qj5]] - hADH III χ chain + inhibitor + NAD<br /> | ||
| + | **[[8gv3]] - hADH III + inhibitor + NAD – Cryo EM | ||
**[[4dl9]], [[4dlb]] – tADH III + NAD – tomato<br /> | **[[4dl9]], [[4dlb]] – tADH III + NAD – tomato<br /> | ||
**[[4dla]] – tADH III<br /> | **[[4dla]] – tADH III<br /> | ||
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**[[1d1s]], [[1agn]] – hADH IV σ chain + NAD<br /> | **[[1d1s]], [[1agn]] – hADH IV σ chain + NAD<br /> | ||
**[[1d1t]] - hADH IV σ chain (mutant) + NAD<br /> | **[[1d1t]] - hADH IV σ chain (mutant) + NAD<br /> | ||
| - | **[[2jhf]], [[2jhg]], [[1het]], [[1heu]], [[1hf3]], [[1ee2]], [[2oxi]], [[2ohx]], [[6adh]] - hoADH IV e chain + NAD<br /> | + | **[[2jhf]], [[2jhg]], [[1het]], [[1heu]], [[1hf3]], [[1ee2]], [[2oxi]], [[2ohx]], [[6adh]], [[7udd]], [[8g41]] - hoADH IV e chain + NAD<br /> |
**[[6nbb]] - hoADH IV e chain + NAD – Cryo EM<br /> | **[[6nbb]] - hoADH IV e chain + NAD – Cryo EM<br /> | ||
**[[1adb]], [[1adc]], [[1adf]], [[1adg]], [[7adh]], [[5vn1]] - hoADH IV e chain + NAD derivative<br /> | **[[1adb]], [[1adc]], [[1adf]], [[1adg]], [[7adh]], [[5vn1]] - hoADH IV e chain + NAD derivative<br /> | ||
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*ADH IV ternary complex | *ADH IV ternary complex | ||
| - | **[[3oq6]], [[1qv6]], [[1qv7]], [[1a71]], [[1axe]], [[1axg]], [[4nfh]], [[4nfs]], [[4ng5]], [[5kje]], [[5kjc]], [[5kj6]], [[5kj1]], [[5kcz]], [[5kcp]], [[5cdt]], [[5cds]], [[5cdg]], [[6o91]], [[6oa7]], [[6owm]], [[6owp]] | + | **[[1hld]], [[1mg0]], [[4dwv]], [[4dxh]], [[5kjf]], [[6xt2]], [[7jqa]], [[7k35]], [[7ua6]], [[7uc9]], [[7uca]], [[7ucu]], [[7ude]], [[7udr]], [[7uec]], [[7uee]], [[7uef]], [[7uei]], [[7uej]], [[7uhv]], [[7uhw]], [[7uhx]] - hoADH IV e chain + NAD + alcohol |
| - | + | **[[3oq6]], [[1qv6]], [[1qv7]], [[1a71]], [[1axe]], [[1axg]], [[4nfh]], [[4nfs]], [[4ng5]], [[5kje]], [[5kjc]], [[5kj6]], [[5kj1]], [[5kcz]], [[5kcp]], [[5cdt]], [[5cds]], [[5cdg]], [[6o91]], [[6oa7]], [[6owm]], [[6owp]], [[7u9n]], [[7uhw]], [[8e39]], [[8e7u]], [[8g2l]], [[8g4v]] – hoADH IV e chain (mutant) + NAD + alcohol<br /> | |
| - | **[[1p1r]], [[1ldy]], [[1lde]] - hoADH IV e chain + NADH + formamide derivative<br /> | + | **[[1p1r]], [[1ldy]], [[1lde]], [[7rm6]], [[8ecs]], [[8ect]], [[8ecu]], [[8ee3]] - hoADH IV e chain + NADH + formamide derivative<br /> |
**[[1n92]] - hoADH IV e chain + NAD + pyrazole derivative<br /> | **[[1n92]] - hoADH IV e chain + NAD + pyrazole derivative<br /> | ||
**[[1bto]], [[3bto]] - hoADH IV e chain + NADH + butylthiolane derivative<br /> | **[[1bto]], [[3bto]] - hoADH IV e chain + NADH + butylthiolane derivative<br /> | ||
| - | **[[1n8k]] - hoADH IV e chain (mutant) + NAD + pyrazole<br /> | + | **[[1n8k]], [[5cdu]], [[8g2x]]] - hoADH IV e chain (mutant) +Zn + NAD + pyrazole<br /> |
| - | **[[ | + | **[[8g2s]] - hoADH IV e chain (mutant) + NAD + capric acid |
**[[5vj5]] - hoADH IV e chain + Zn + phenanthroline<br /> | **[[5vj5]] - hoADH IV e chain + Zn + phenanthroline<br /> | ||
**[[5vjg]] - hoADH IV e chain + Zn + bipyridine<br /> | **[[5vjg]] - hoADH IV e chain + Zn + bipyridine<br /> | ||
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**[[5vl0]] - hoADH IV e chain + Zn + formamide derivative <br /> | **[[5vl0]] - hoADH IV e chain + Zn + formamide derivative <br /> | ||
**[[6cy3]], [[6cxx]] - hoADH IV e chain (mutant) + Zn + dephosphoCoA<br /> | **[[6cy3]], [[6cxx]] - hoADH IV e chain (mutant) + Zn + dephosphoCoA<br /> | ||
| - | **[[ | + | **[[8eix]], [[8eiy]] - hoADH IV e chain (mutant) + Zn + Co + NAD + formamide derivative<br /> |
| + | **[[8eiw]] - hoADH IV e chain + Zn + Co + NAD + formamide derivative<br /> | ||
| + | **[[7utw]] - hoADH IV e chain + Zn + Cd + NAD + formamide derivative<br /> | ||
*ADH | *ADH | ||
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**[[4bmn]] – ReADH - ''Ralstonia eutropha''<br /> | **[[4bmn]] – ReADH - ''Ralstonia eutropha''<br /> | ||
**[[4z6k]] – ADH - ''Moraxella''<br /> | **[[4z6k]] – ADH - ''Moraxella''<br /> | ||
| + | **[[7cyi]] – ADH – ''Artemisia annua''<br /> | ||
| + | **[[8ij7]] – BgADH – ''Burkholderia gladioli''<br /> | ||
| + | **[[8ij8]] – BgADH (mutant)<br /> | ||
*ADH binary complex | *ADH binary complex | ||
| + | **[[1agn]] – hADH (sigma) +NAD<br /> | ||
| + | **[[1cdo]] – ADH + NAD - cod<br /> | ||
**[[3l77]], [[3tn7]] – ADH short-chain + NADP – ''Thermococcus sibiricus''<br /> | **[[3l77]], [[3tn7]] – ADH short-chain + NADP – ''Thermococcus sibiricus''<br /> | ||
**[[1h2b]] – ADH + NAD – ''Aeropyrum pernix''<br /> | **[[1h2b]] – ADH + NAD – ''Aeropyrum pernix''<br /> | ||
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**[[3ip1]] – TmADH + Cd<br /> | **[[3ip1]] – TmADH + Cd<br /> | ||
**[[1b16]], [[1b14]], [[1b15]] - SlADH + NAD derivative<br /> | **[[1b16]], [[1b14]], [[1b15]] - SlADH + NAD derivative<br /> | ||
| - | **[[1cdo]] – ADH + NAD - cod<br /> | ||
| - | **[[1rhc]] – ADH F420-dependent +F420-acetone – ''Methanoculleus thermophilus''<br /> | ||
| - | **[[1agn]] – hADH (sigma) +NAD<br /> | ||
**[[3pii]] – GsADH + butyramide<br /> | **[[3pii]] – GsADH + butyramide<br /> | ||
**[[3rj5]], [[3rj9]] – SlADH (mutant) + NAD<br /> | **[[3rj5]], [[3rj9]] – SlADH (mutant) + NAD<br /> | ||
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**[[6qhe]] – ADH + NAD – ''Arthrobacter''<br /> | **[[6qhe]] – ADH + NAD – ''Arthrobacter''<br /> | ||
**[[6z42]] – ADH + Zn – ''Halomonas elongata''<br /> | **[[6z42]] – ADH + Zn – ''Halomonas elongata''<br /> | ||
| + | **[[8ij6]], [[8ijg]] – BgADH + NADP<br /> | ||
| + | **[[8h2a]] – ADH + NAD – ''Formosa agariphila''<br /> | ||
| + | **[[8h2b]] – ADH + NAD – ''Zobellia galactanivorans''<br /> | ||
| + | **[[8uar]] – RrADH + Zn – ''Rhodococcus ruber''<br /> | ||
*ADH ternary complex | *ADH ternary complex | ||
| + | **[[3cv7]] – pADH + NAD + NAP<br /> | ||
**[[1mg5]] – ADH + NADH + acetate – ''Drosophila melanogaster''<br /> | **[[1mg5]] – ADH + NADH + acetate – ''Drosophila melanogaster''<br /> | ||
**[[1r37]] – SsADH + NAD + alcohol<br /> | **[[1r37]] – SsADH + NAD + alcohol<br /> | ||
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**[[1b2l]] - SlADH + NAD + cyclohexanone<br /> | **[[1b2l]] - SlADH + NAD + cyclohexanone<br /> | ||
**[[1llu]] - ADH + NAD + alcohol – ''Pseudomonas aeruginosa''<br /> | **[[1llu]] - ADH + NAD + alcohol – ''Pseudomonas aeruginosa''<br /> | ||
| - | **[[3cv7]] – pADH + NAD + NAP<br /> | ||
**[[3rf7]] – SoADH + NAD + Fe + Ni<br /> | **[[3rf7]] – SoADH + NAD + Fe + Ni<br /> | ||
**[[3s2e]] – ReADH + NAD + Zn<br /> | **[[3s2e]] – ReADH + NAD + Zn<br /> | ||
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**[[6c7l]] – TthADH + monophosphoadenosine diphosphate <br /> | **[[6c7l]] – TthADH + monophosphoadenosine diphosphate <br /> | ||
**[[6c75]] – TthADH + NADP + Fe + monophosphoadenosine diphosphate <br /> | **[[6c75]] – TthADH + NADP + Fe + monophosphoadenosine diphosphate <br /> | ||
| + | **[[8uas]] – RrADH + NAD + Zn <br /> | ||
*NADP-dependent ADH | *NADP-dependent ADH | ||
**[[4gac]] - mADH<br /> | **[[4gac]] - mADH<br /> | ||
| - | **[[4hfj]] – toADH – tobacco<br /> | + | **[[4hfj]] – toADH – tobacco<br /> |
| - | **[[ | + | **[[2nvb]], [[7xl5]] - TbADH (mutant) – ''Thermoanaerobacter brockii''<br /> |
| - | + | ||
| - | + | ||
**[[3ftn]], [[3fpc]], [[3fpl]], [[3fsr]] – ADH chimera<br /> | **[[3ftn]], [[3fpc]], [[3fpl]], [[3fsr]] – ADH chimera<br /> | ||
**[[1y9a]] - EhADH – ''Entamoeba histolytica''<br /> | **[[1y9a]] - EhADH – ''Entamoeba histolytica''<br /> | ||
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*NADP-dependent ADH complex | *NADP-dependent ADH complex | ||
| - | **[[1kev]] – CbADH + NADPH<br /> | ||
| - | **[[1bxz]] – CbADH catalytic domain + alcohol<br /> | ||
**[[1ykf]] – TbADH + NADP<br /> | **[[1ykf]] – TbADH + NADP<br /> | ||
**[[3h4g]] – pADH + NADP<br /> | **[[3h4g]] – pADH + NADP<br /> | ||
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**[[5yvm]] – bspADH + Mn + NADP derivative – brine sea pool<br /> | **[[5yvm]] – bspADH + Mn + NADP derivative – brine sea pool<br /> | ||
**[[5yvr]], [[5yvs]] – bspADH (mutant) + Mn + NADP <br /> | **[[5yvr]], [[5yvs]] – bspADH (mutant) + Mn + NADP <br /> | ||
| - | **[[5z2x]] – ADH + NADP – ''Kluyveromyces polyspora''<br /> | + | **[[5z2x]], [[7c3v]] – ADH + NADP – ''Kluyveromyces polyspora''<br /> |
| - | **[[ | + | **[[7ymu]] – CgADH – ''Candida glabrata''<br /> |
| - | **[[ | + | **[[7ymb]] – CgADH + NADP <br /> |
*R-specific ADH | *R-specific ADH | ||
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**[[1zjy]], [[1zjz]], [[1zk0]], [[1zk1]] – LbRADH (mutant) + NADH + alcohol<br /> | **[[1zjy]], [[1zjz]], [[1zk0]], [[1zk1]] – LbRADH (mutant) + NADH + alcohol<br /> | ||
**[[1zk4]] - LbRADH (mutant) + NADH + acetophenone<br /> | **[[1zk4]] - LbRADH (mutant) + NADH + acetophenone<br /> | ||
| - | **[[4rf4]] – LkADH + Mg - ''Lactobacillus kefiri''<br /> | + | **[[4rf4]], [[7p36]] – LkADH + Mg - ''Lactobacillus kefiri''<br /> |
| - | **[[4rf5]], [[4rf3]] – LkADH (mutant) + Mg <br /> | + | **[[4rf5]], [[4rf3]], [[7p7y]] – LkADH (mutant) + Mg <br /> |
**[[4rf2]] – LkADH + Mg + NADP<br /> | **[[4rf2]] – LkADH + Mg + NADP<br /> | ||
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**[[6zcw]] - PpQADH II + PQQ + Pr<br /> | **[[6zcw]] - PpQADH II + PQQ + Pr<br /> | ||
**[[1kb0]] - QADH I + PQQ + heme – ''Comamonas testosteroni'' | **[[1kb0]] - QADH I + PQQ + heme – ''Comamonas testosteroni'' | ||
| + | |||
| + | *PQQ-dependent ADH | ||
| + | |||
| + | **[[7wmd]] - DaADH – ''Devosia albogilva''<br /> | ||
| + | **[[7wmk]] - DaADH + PQQ <br /> | ||
*Quinone-dependent ADH | *Quinone-dependent ADH | ||
**[[4cvc]], [[4cvb]] – ADH + Zn + PQQ + propanoate – ''Pseudogluconobacter saccharoketogenes''<br /> | **[[4cvc]], [[4cvb]] – ADH + Zn + PQQ + propanoate – ''Pseudogluconobacter saccharoketogenes''<br /> | ||
| + | **[[8gy2]] – ADH + PQQ + heme + ubiquinone + coenzyme Q10 – ''Gluconobactert oxydans'' - Cryo EM<br /> | ||
| + | |||
| + | *Secondary ADH | ||
| + | |||
| + | **[[7uut]], [[7ux4]] – TpSADH (mutant) + NADP + alcohol<br /> | ||
| + | **[[6kq9]], [[6kqb]] - SADH – ''Micrococcus luteus''<br /> | ||
| + | **[[1rhc]] – SADH +F420-acetone –'' Methanoculleus thermophilus''<br /> | ||
| + | **[[7utc]] – TeSADH + DMSO + NADP + Zn – ''Thermoanaerobacter ethanolicus''<br /> | ||
| + | **[[7uut]] – TeSADH (mutant) + NADP + Zn <br /> | ||
| + | **[[1ped]] - CbSADH – ''Clostridium beijerinckii''<br /> | ||
| + | **[[2b83]], [[1jqb]] – CbSADH (mutant)<br /> | ||
| + | **[[1kev]] – CbSADH + NADPH<br /> | ||
| + | **[[1bxz]] – CbSADH catalytic domain + alcohol<br /> | ||
| + | **[[2xaa]] – RrSADH I + NAD + alcohol<br /> | ||
*Hydroxyacyl-CoA dehydrogenase (HADH) | *Hydroxyacyl-CoA dehydrogenase (HADH) | ||
| - | **Short chain HADH | + | **Short chain HADH (SCHAD) |
| - | ***[[1so8]] – | + | ***[[1so8]] – hSCHAD II <BR /> |
| - | ***[[3rqs]] - | + | ***[[3rqs]] - hSCHAD <BR /> |
| - | ***[[1f14]] - | + | ***[[1f14]] - hSCHAD (mutant) |
| + | ***[[7yic]] - SCHAD - ''Leifsonia'' <BR /> | ||
**Short chain HADH binary complex | **Short chain HADH binary complex | ||
| - | ***[[1f12]] - | + | ***[[1f12]] - hSCHAD (mutant) + hydroxybutyryl-CoA<BR /> |
| - | ***[[1f17]], [[1lsj]], [[1lso]] - | + | ***[[1f17]], [[1lsj]], [[1lso]] - hSCHAD (mutant) + NAD<BR /> |
| - | ***[[1zbq]] - | + | ***[[1zbq]] - hSCHAD IV + NAD<BR /> |
| - | ***[[1e3s]] - | + | ***[[1e3s]] - rSCHAD + NAD – rat |
**Short chain HADH ternary complex | **Short chain HADH ternary complex | ||
| - | ***[[1u7t]] - | + | ***[[1u7t]] - hSCHAD II + inhibitor + NAD<BR /> |
| - | ***[[1f0y]] - | + | ***[[1f0y]] - hSCHAD + acetoacetyl-CoA + NAD<BR /> |
| - | ***[[1il0]], [[1m75]], [[1m76]] - | + | ***[[1il0]], [[1m75]], [[1m76]] - hSCHAD (mutant) + acetoacetyl-CoA + NAD<BR /> |
| - | ***[[1e3w]] - | + | ***[[1e3w]] - rSCHAD + 3-keto-butyrate + NAD<BR /> |
| - | ***[[1e6w]] - | + | ***[[1e6w]] - rSCHAD + estradiol + NAD<BR /> |
*Unspecified HADH | *Unspecified HADH | ||
Current revision
3D Structures of Alcohol dehydrogenase
Updated on 17-September-2024
