Aldehyde dehydrogenase 3D structures

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Line 10: Line 10:
**[[4wpn]] - hALDH1 + inhibitor<br />
**[[4wpn]] - hALDH1 + inhibitor<br />
**[[4wp7]] - hALDH1 (mutant) + inhibitor<br />
**[[4wp7]] - hALDH1 (mutant) + inhibitor<br />
-
**[[4wb9]] - hALDH1 + NAD derivative <br />
+
**[[4wb9]], [[8wfq]] - hALDH1 + NAD derivative <br />
**[[4x4l]] - hALDH1 + NAD derivative + inhibitor<br />
**[[4x4l]] - hALDH1 + NAD derivative + inhibitor<br />
**[[1ht0]] – hALDH1 γ subunit (mutant) + Zn + NAD<br />
**[[1ht0]] – hALDH1 γ subunit (mutant) + Zn + NAD<br />
Line 24: Line 24:
*ALDH family 1 A (retinal dehydrogenase)
*ALDH family 1 A (retinal dehydrogenase)
-
**[[4x4l]], [[5l2m]], [[5l2n]], [[5l2o]], [[7jws]], [[7jwt]], [[7jwu]], [[7jwv]], [[7jww]] – hRALDH1A1 + inhibitor<br />
+
**[[4x4l]], [[5l2m]], [[5l2n]], [[5l2o]], [[7jws]], [[7jwt]], [[7jwu]], [[7jwv]], [[7jww]], [[8t0n]], [[8t0t]] – hRALDHA1 + inhibitor<br />
-
**[[5tei]], [[6dum]] – hRALDH1A1 + NAD + inhibitor<br />
+
**[[8d46]], [[8dno]], [[8pvh]] – hRALDH1A1 – Cryo EM<br />
 +
**[[8ene]] – hRALDH1A1 + NAD – Cryo EM<br />
 +
**[[4wb9]] – hRALDH1A1 + NAD <br />
 +
**[[5tei]], [[6dum]], [[7um9]] – hRALDH1A1 + NAD + inhibitor<br />
**[[6alj]], [[6b5g]], [[6b5h]], [[6b5i]] – hRALDH1A22 + NAD + inhibitor<br />
**[[6alj]], [[6b5g]], [[6b5h]], [[6b5i]] – hRALDH1A22 + NAD + inhibitor<br />
 +
**[[7qk7]] – hRALDH1A3 <br />
 +
**[[7qk9]] – hRALDH1A3 + ATP<br />
**[[5fhz]] – hRALDH1A3 + NAD + retinol<br />
**[[5fhz]] – hRALDH1A3 + NAD + retinol<br />
-
**[[6s6w]], [[6te5]], [[6try]], [[7a6q]] – hRALDH1A3 + NAD + inhibitor<br />
+
**[[6s6w]], [[6te5]], [[6try]], [[7a6q]], [[7qk8]] – hRALDH1A3 + NAD + inhibitor<br />
 +
**[[7mjc]] – hRALDH1B1 + NAD <br />
 +
**[[7mjd]], [[7rad]] – hRALDH1B1 + NAD + inhibitor<br />
**[[5abm]] – sRALDHA1 + inhibitor<br />
**[[5abm]] – sRALDHA1 + inhibitor<br />
 +
**[[7yob]] – mRALDHA1 - mouse<br />
*ALDH class 2
*ALDH class 2
 +
**[[8shs]] – hALDH2 – Cryo EM<br />
**[[3n80]], [[1o05]], [[4kwf]] – hALDH2 residues 18-517<BR />
**[[3n80]], [[1o05]], [[4kwf]] – hALDH2 residues 18-517<BR />
**[[3n81]], [[2onn]], [[2ono]], [[1zum]] – hALDH2 residues 18-517 (mutant) <BR />
**[[3n81]], [[2onn]], [[2ono]], [[1zum]] – hALDH2 residues 18-517 (mutant) <BR />
Line 41: Line 50:
**[[3inj]], [[3inl]], [[4kwg]] - hALDH2 residues 18-517 + agonist<BR />
**[[3inj]], [[3inl]], [[4kwg]] - hALDH2 residues 18-517 + agonist<BR />
**[[2vle]] - hALDH2 residues 24-517 + daidzin<BR />
**[[2vle]] - hALDH2 residues 24-517 + daidzin<BR />
-
**[[1nzx]], [[1nzz]], [[1o00]], [[1o02]], [[1cw3]], [[4x2q]] - hALDH2 residues 18-517 + NAD<BR />
+
**[[1nzx]], [[1nzz]], [[1o00]], [[1o02]], [[1cw3]], [[4x2q]], [[8dr9]]- hALDH2 residues 18-517 + NAD<BR />
**[[3n82]], [[3n83]], [[2onm]], [[2onp]], [[1nzw]], [[1o04]] – hALDH2 residues 18-517 (mutant) + NADH<BR />
**[[3n82]], [[3n83]], [[2onm]], [[2onp]], [[1nzw]], [[1o04]] – hALDH2 residues 18-517 (mutant) + NADH<BR />
**[[3sz9]] - hALDH2 residues 18-517 + inhibitor<br />
**[[3sz9]] - hALDH2 residues 18-517 + inhibitor<br />
Line 61: Line 70:
**[[3sza]] - hALDH3A1<br />
**[[3sza]] - hALDH3A1<br />
**[[3szb]], [[4l1o]], [[4l2o]] – hALDH3A1 + inhibitor<br />
**[[3szb]], [[4l1o]], [[4l2o]] – hALDH3A1 + inhibitor<br />
 +
**[[8bb8]] – hALDH3A1 + octanal<br />
**[[4h80]] - hALDH3A1 (mutant) + inhibitor<br />
**[[4h80]] - hALDH3A1 (mutant) + inhibitor<br />
**[[4qgk]] – hALDH3A2 + ligand<br />
**[[4qgk]] – hALDH3A2 + ligand<br />
Line 79: Line 89:
**[[4lgz]] – mALDH4A1 + acetate<br />
**[[4lgz]] – mALDH4A1 + acetate<br />
**[[3v9l]] – mALDH4A1 + NAD<br />
**[[3v9l]] – mALDH4A1 + NAD<br />
 +
**[[7mer]], [[7mes]] – mALDH4A1 + Pro derivative<br />
*ALDH family 5 (succinate-semialdehyde dehydrogenase)
*ALDH family 5 (succinate-semialdehyde dehydrogenase)
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**[[3vos]], [[3tz6]], [[3vos]] – Aspartate-semi-MtALDH<BR />
**[[3vos]], [[3tz6]], [[3vos]] – Aspartate-semi-MtALDH<BR />
**[[2cq8]] - Formyltetrahydrofolate-hALDH PP-binding domain - NMR<BR />
**[[2cq8]] - Formyltetrahydrofolate-hALDH PP-binding domain - NMR<BR />
 +
**[[7rlt]] - Formyltetrahydrofolate-rALDH1L1<br />
**[[2nac]] – Formate-PsALDH<BR />
**[[2nac]] – Formate-PsALDH<BR />
**[[3i44]] – ALDH – ''Bartonella henselae''<BR />
**[[3i44]] – ALDH – ''Bartonella henselae''<BR />
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**[[2cfi]] - Formyltetrahydrofolate-hALDH hydrolase domain + formyltetrahydropterin<BR />
**[[2cfi]] - Formyltetrahydrofolate-hALDH hydrolase domain + formyltetrahydropterin<BR />
 +
**[[7rlu]] - Formyltetrahydrofolate-rALDH1L1 + NADP <br />
 +
**[[2o2p]] – Formyltetrahydrofolate-rALDH C-terminal<br />
**[[4a0m]], [[4v37]] – spALDH + NAD – spinach<br />
**[[4a0m]], [[4v37]] – spALDH + NAD – spinach<br />
**[[5a2d]], [[4v3f]] – spALDH + choline<br />
**[[5a2d]], [[4v3f]] – spALDH + choline<br />
Line 152: Line 166:
*NADP-dependent ALDH
*NADP-dependent ALDH
-
**[[4gac]] – ALDH – mouse<br />
+
**[[4gac]] – mALDH <br />
-
**[[3k2w]] - Betaine-ALDH – ''Pseudoalteromonas atlantica''<BR />
+
**[[2hg2]], [[2opx]] – Lactaldehyde-EcALDH <BR />
**[[2hg2]], [[2opx]] – Lactaldehyde-EcALDH <BR />
-
**[[2o2p]] – Formyltetrahydrofolate-rALDH C-terminal<br />
 
**[[2y51]], [[2y52]], [[2y53]], [[2y5d]] – BxALDH (mutant) – ''Burkholderia xenovorans''<br />
**[[2y51]], [[2y52]], [[2y53]], [[2y5d]] – BxALDH (mutant) – ''Burkholderia xenovorans''<br />
**[[3uw3]] - aspartate–semi-BtALDH – ''Burkholderia thailandensis''<br />
**[[3uw3]] - aspartate–semi-BtALDH – ''Burkholderia thailandensis''<br />
Line 165: Line 177:
*NADP-dependent ALDH binary complexes
*NADP-dependent ALDH binary complexes
-
**[[2wox]], [[2wme]], [[2xdr]], [[3zqa]] - Betaine-PaALDH + NADP<BR />
+
**[[2wox]], [[2wme]], [[2xdr]], [[3zqa]] - PaBDH + NADP<BR />
**[[2ilu]] - Lactaldehyde-EcALDH + NADP<BR />
**[[2ilu]] - Lactaldehyde-EcALDH + NADP<BR />
**[[3rhd]] - Lactaldehyde-MjALDH + NADP - ''Methanocaldococcus jannaschii''<br />
**[[3rhd]] - Lactaldehyde-MjALDH + NADP - ''Methanocaldococcus jannaschii''<br />
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**[[2vro]] – BxALDH + NADP + alcohol <br />
**[[2vro]] – BxALDH + NADP + alcohol <br />
-
*Indole-3-ALDH
+
*Indole-3-acetaldehyde dehydrogenase
**[[5iuu]] – PsIALDH – ''Pseudomonas syringae''<br />
**[[5iuu]] – PsIALDH – ''Pseudomonas syringae''<br />
**[[5iuv]] – PsIALDH + NAD<br />
**[[5iuv]] – PsIALDH + NAD<br />
-
**[[5iuw]] – PsIALDH + NAD + indole acetate<br />
+
**[[5iuw]], [[7jso]] – PsIALDH + NAD + indole acetate<br />
*NAD-dependent glyceraldehyde-3-phosphate dehydrogenase
*NAD-dependent glyceraldehyde-3-phosphate dehydrogenase
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*NAD/NADP-dependent betaine ALDH
*NAD/NADP-dependent betaine ALDH
-
**[[1a4s]] - Betaine-cALDH – cod<br />
+
**[[1a4s]] - cBADH – cod<br />
-
**[[1bpw]] - Betaine-cALDH + NAD<br />
+
**[[1bpw]] - cBADH + NAD<br />
-
**[[3r31]] – Betaine-ALDH – ''Agrobacterium tumefaciens''<br />
+
**[[3r31]] – BADH – ''Agrobacterium tumefaciens''<br />
-
**[[4mpb]], [[4nu9]], [[4q92]], [[4qto]] - Betaine-SaALDH – ''Staphylococcus aureus''<br />
+
**[[4mpb]], [[4nu9]], [[4q92]], [[4qto]] - SaBADH – ''Staphylococcus aureus''<br />
-
**[[4qje]] - Betaine-SaALDH (mutant)<br />
+
**[[4qje]] - SaBADH (mutant)<br />
-
**[[4zxu]], [[4zwl]] - Betaine-SaALDH (mutant) + NAD<br />
+
**[[4zxu]], [[4zwl]] - SaBADH (mutant) + NAD<br />
-
**[[4cbb]], [[6bpg]] - Betaine-PaALDH - ''Pseudomonas aeruginosa''<br />
+
**[[4cbb]], [[6bpg]] - PaBADH - ''Pseudomonas aeruginosa''<br />
-
**[[6bjp]] - Betaine-PaALDH (mutant)<br />
+
**[[6bjp]] - PaBADH (mutant)<br />
-
**[[4mpy]], [[4nea]] - Betaine-SaALDH + NAD<br />
+
**[[4mpy]], [[4nea]] - SaBADH + NAD<br />
-
**[[4qn2]], [[5ez4]], [[5eyu]], [[5dib]] - Betaine-SaALDH (mutant) + NAD<br />
+
**[[4qn2]], [[5ez4]], [[5eyu]], [[5dib]] - SaBADH (mutant) + NAD<br />
-
**[[4caz]] - Betaine-PaALDH + NAD derivative<br />
+
**[[4caz]] - PaBADH + NAD derivative<br />
-
**[[3k2w]] - Betaine-ALDH – ''Pseudoalteromonas atlantica''<br />
+
**[[3k2w]] - BADH – ''Pseudoalteromonas atlantica''<br />
-
**[[6wsa]] - Betaine-BpALDH<br />
+
**[[6wsa]] - BpBADH<br />
-
**[[6wsb]] - Betaine-BpALDH + NAD<br />
+
**[[6wsb]] - BpBADH + NAD<br />
-
**[[2wox]], [[2wme]], [[2xdr]], [[3zqa]] - Betaine-PaALDH + NADP<br />
+
**[[2wox]], [[2wme]], [[2xdr]], [[3zqa]] - PaBADH + NADP<br />
 +
**[[3k2w]] - BADH – ''Pseudoalteromonas atlantica''<BR />
 +
**[[7swk]] – KpBADH – ''Klebsiella pneumoniae''<br />
 +
**[[8u9b]] – KpBADH (mutant) <br />
 +
**[[8uzo]] – KpBADH + ADP<br />
 +
**[[8uzn]], [[8vqz]], [[8vr0]], [[8vr1]] – KpBADH (mutant) + nucleotide<br />
 +
**[[8uzi]] – KpBADH (mutant) + betaine<br />
 +
**[[8skf]] – KpBADH (mutant) + NAD<br />
 +
**[[8uzk]], [[8uzm]] – KpBADH (mutant) + NADP<br />
*Uncharacterized ALDH
*Uncharacterized ALDH
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**[[5mz8]] – PhpALDH 21 + succinate<br />
**[[5mz8]] – PhpALDH 21 + succinate<br />
**[[5n5s]] – PhpALDH 21 + NADP<br />
**[[5n5s]] – PhpALDH 21 + NADP<br />
 +
**[[8of3]] – PhpALDH 5F1 (mutant)<br />
 +
**[[8ofm]] – PhpALDH 5F1 + NAD<br />
**[[6mvr]] – LoALDH 16 - ''Loktanella''<br />
**[[6mvr]] – LoALDH 16 - ''Loktanella''<br />
**[[6mvu]] – LoALDH 16 (mutant)<br />
**[[6mvu]] – LoALDH 16 (mutant)<br />
Line 299: Line 321:
**[[6k0z]] - SaALDH<br />
**[[6k0z]] - SaALDH<br />
**[[6k10]] – SaALDH (mutant)<br />
**[[6k10]] – SaALDH (mutant)<br />
 +
**[[8hap]] – ALDH +MPADP – ''Sulfurisphaera tokodaii''<br />
 +
**[[7uyy]] – PaALDH + NAD<br />
 +
**[[8ixi]] - KpALDH<br />
*Antiquitin
*Antiquitin

Current revision

3D Structures of Aldehyde dehydrogenase

Updated on 18-September-2024

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel

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